A monolithic silicon pixel prototype produced for the MONOLITH ERC Advanced project was irradiated with 70 MeV protons up to a fluence of 1 × 10161 MeV neq/cm2. The ASIC contains a matrix of hexagonal pixels with 100 μm pitch, readout by low-noise and very fast SiGe HBT frontend electronics. Wafers with 50 μm thick epilayer with a resistivity of 350 Ωcm were used to produce a fully depleted sensor. Laboratory tests conducted with a90Sr source show that the detector works satisfactorily after irradiation. The signal-to-noise ratio is not seen to change up to fluence of 6 × 1014neq/cm2. The signal time jitter was estimated as the ratio between the voltage noise and the signal slope at threshold. At -35°C, sensor bias voltage of 200 V and frontend power consumption of 0.9 W/cm2, the time jitter of the most-probable signal amplitude was estimated to be σt90Sr = 21 ps for proton fluence up to 6 × 1014neq/cm2 and 57 ps at 1 × 1016neq/cm2. Increasing the sensor bias to 250 V and the analog voltage of the preamplifier from 1.8 to 2.0 V provides a time jitter of 40 ps at 1 × 1016neq/cm2.