The impact of obesity on oocytes: evidence for lipotoxicity mechanisms
Linda L.-Y. Wu A , Robert J. Norman A and Rebecca L. Robker A BA The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia.
B Corresponding author. Email: [email protected]
Reproduction, Fertility and Development 24(1) 29-34 https://doi.org/10.1071/RD11904
Published: 6 December 2011
Abstract
Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality.
Additional keywords: endoplasmic reticulum stress, palmitate.
References
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