Issue 37, 2017, Issue in Progress
From the journal:

RSC Advances

Myrtucomvalones A–C, three unusual triketone–sesquiterpene adducts from the leaves of Myrtus communis ‘Variegata’†

Ming Chen,‡ab   Li-Feng Chen,‡b   Man-Mei Li,bc   Ni-Ping Li,b   Jia-Qing Cao,b   Ying Wang,bc   Yao-Lan Li,bc   Lei Wang*bc  and  Wen-Cai Ye ORCID logo *abc  

* Corresponding authors

a Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P. R. China
E-mail: [email protected]
Tel: +86-20-85221559

b Institute of Traditional Chinese Medicine & Natural Products, JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China
E-mail: [email protected]

c Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, P. R. China

Abstract

Three new triketone–sesquiterpene adducts, myrtucomvalones A–C (1–3), along with four known compounds (4–7) were isolated from the leaves of Myrtus communis ‘Variegata’. Compounds 1 and 2 are the first examples of triketone–cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1–7 displayed inhibitory activities against respiratory syncytial virus (RSV).

Graphical abstract: Myrtucomvalones A–C, three unusual triketone–sesquiterpene adducts from the leaves of Myrtus communis ‘Variegata’

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Article information

DOI
https://doi.org/10.1039/C7RA02260C
Article type
Paper
Submitted
23 Feb 2017
Accepted
17 Apr 2017
First published
25 Apr 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 22735-22740

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Myrtucomvalones A–C, three unusual triketone–sesquiterpene adducts from the leaves of Myrtus communis ‘Variegata’

M. Chen, L. Chen, M. Li, N. Li, J. Cao, Y. Wang, Y. Li, L. Wang and W. Ye, RSC Adv., 2017, 7, 22735 DOI: 10.1039/C7RA02260C

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