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Decellularized extracellular matrix mediates tissue construction and regeneration

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  • Open access
  • Published: 28 December 2021
  • Volume 16, pages 56–82, (2022)
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Frontiers of Medicine Aims and scope Submit manuscript
Decellularized extracellular matrix mediates tissue construction and regeneration
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  • Chuanqi Liu1,2,
  • Ming Pei3,
  • Qingfeng Li2 &
  • …
  • Yuanyuan Zhang4 

  • 3856 Accesses

  • 63 Citations

  • 4 Altmetric

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Abstract

Contributing to organ formation and tissue regeneration, extracellular matrix (ECM) constituents provide tissue with three-dimensional (3D) structural integrity and cellular-function regulation. Containing the crucial traits of the cellular microenvironment, ECM substitutes mediate cell—matrix interactions to prompt stem-cell proliferation and differentiation for 3D organoid construction in vitro or tissue regeneration in vivo. However, these ECMs are often applied generically and have yet to be extensively developed for specific cell types in 3D cultures. Cultured cells also produce rich ECM, particularly stromal cells. Cellular ECM improves 3D culture development in vitro and tissue remodeling during wound healing after implantation into the host as well. Gaining better insight into ECM derived from either tissue or cells that regulate 3D tissue reconstruction or organ regeneration helps us to select, produce, and implant the most suitable ECM and thus promote 3D organoid culture and tissue remodeling for in vivo regeneration. Overall, the decellularization methodologies and tissue/cell-derived ECM as scaffolds or cellular-growth supplements used in cell propagation and differentiation for 3D tissue culture in vitro are discussed. Moreover, current preclinical applications by which ECM components modulate the wound-healing process are reviewed.

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Acknowledgements

We thank Ms. Suzanne Danley (Department of Orthopaedics, West Virginia University) for editing the manuscript. This work was partially supported by Research Grants from the National Institutes of Health (No. 1R01AR067747) to Ming Pei and by NIH/NIAID (Nos. R21AI152832 and R03AI165170) to Yuanyuan Zhang.

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Authors and Affiliations

  1. Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China

    Chuanqi Liu

  2. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

    Chuanqi Liu & Qingfeng Li

  3. Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, 26506, USA

    Ming Pei

  4. Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, 27109, USA

    Yuanyuan Zhang

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  2. Ming Pei
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  3. Qingfeng Li
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  4. Yuanyuan Zhang
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Corresponding authors

Correspondence to Qingfeng Li or Yuanyuan Zhang.

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Chuanqi Liu, Ming Pei, Qingfeng Li, and Yuanyuan Zhang declare that they have no conflict of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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Liu, C., Pei, M., Li, Q. et al. Decellularized extracellular matrix mediates tissue construction and regeneration. Front. Med. 16, 56–82 (2022). https://doi.org/10.1007/s11684-021-0900-3

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  • Received: 28 April 2021

  • Accepted: 23 September 2021

  • Published: 28 December 2021

  • Issue Date: February 2022

  • DOI: https://doi.org/10.1007/s11684-021-0900-3

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Keywords

  • decellularized extracellular matrix
  • 3D culture
  • organoids
  • tissue repair
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