DCTD Programs
NCI-Funded Canine Immunotherapy Trials Network Treats Pet Dogs to Study Cancers Common to Humans
for diffuse large B cell lymphoma
In 2017, NCI provided funding in precision medicine oncology to six U.S. veterinary schools of medicine (RFA-CA-17-001 and RFA-CA-17-002). These grants, which are part of the Cancer Moonshot℠, fund a network of veterinary oncologists and surgeons to enroll pet dogs as patients in immunotherapy clinical trials of cancer.
Network Goal
Promote the development of cancer immunotherapies for several common human cancers — glioma, osteosarcoma, melanoma, and lymphoma — through comparative oncology via a collaborative immunotherapy network
The Consortium, called PRECINCT 
— PRE-medical Cancer Immunotherapy Network Canine Trials — consists of a Coordinating Center at the University of Pennsylvania and the following Canine Clinical Trial Sites:
| Institution/Principal Investigator(s) | Clinical Trial | Cancer Type | Contact for Canine Patient Enrollment |
|---|---|---|---|
| University of California, Davis/ Robert Canter; Robert Rebhun |
Enhancing Natural Killer Immunotherapy with First-in-Dog Trials of Inhaled Recombinant IL-15 and Super-agonist IL-15 in Naturally Occurring Canine Cancers | Osteosarcoma and Melanoma |
Teri Guerrero 530-752-0125 [email protected] |
|
University of Alabama at Birmingham (UAB)/ Consortium includes the Auburn University |
Canine Immuno-Neurotherapeutics (Combination immunotherapies for canine brain tumors) |
Glioma |
Dr. Chambers:
Dr. Yanke ([email protected]) |
| Colorado State University Fort Collins, CO/ Steven Dow (CSU) Cheryl London (Tufts) |
Optimizing Novel Immunotherapy Combinations Targeting the Tumor Microenvironment in Canine Spontaneous Osteosarcoma | Osteosarcoma | Kara Hall: 970-297-4001 [email protected] |
| Tufts University N. Grafton, MA/ Cheryl London |
Enhancing the Efficacy of Immunotherapy in DLBCL Using Rational Combination Approaches | Lymphoma | Diane Welsh: [email protected] |
| University of Minnesota St. Paul, MN/ Grace Elizabeth Pluhar |
Novel Combined Immunotherapeutic Strategies for Glioma: Using Pet Dogs as a Large Animal Spontaneous Model | Glioma | Clinical Investigation Center — Sara Pracht: 612-626-3569 Or Dr. Liz Pluhar: 612-625-1162 |