About: Manifaxine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Manifaxine (developmental code name GW-320,659) is a norepinephrine–dopamine reuptake inhibitor developed by GlaxoSmithKline through structural modification of radafaxine, an isomer of hydroxybupropion and one of the active metabolites of bupropion. Manifaxine was researched for treatment of attention deficit hyperactivity disorder (ADHD) and obesity and was found to be safe, reasonably effective, and well-tolerated for both applications. However, no results were reported following these initial trials and development was discontinued.

Property	Value
dbo:abstract	Manifaxine (developmental code name GW-320,659) is a norepinephrine–dopamine reuptake inhibitor developed by GlaxoSmithKline through structural modification of radafaxine, an isomer of hydroxybupropion and one of the active metabolites of bupropion. Manifaxine was researched for treatment of attention deficit hyperactivity disorder (ADHD) and obesity and was found to be safe, reasonably effective, and well-tolerated for both applications. However, no results were reported following these initial trials and development was discontinued. (en) マニファキシン(Manifaxine)は、グラクソ・スミスクラインがブプロピオンの活性代謝物であるの構造修飾によって開発した薬品である。として作用する。注意欠陥・多動性障害や肥満の治療に向けた研究が再開され、安全で効果があり、どちらの用途での使用にも耐えることが示されたが、この最初の治験の後は結果の報告がなく、現在の状況は明らかではない。 (ja)
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rdfs:comment	Manifaxine (developmental code name GW-320,659) is a norepinephrine–dopamine reuptake inhibitor developed by GlaxoSmithKline through structural modification of radafaxine, an isomer of hydroxybupropion and one of the active metabolites of bupropion. Manifaxine was researched for treatment of attention deficit hyperactivity disorder (ADHD) and obesity and was found to be safe, reasonably effective, and well-tolerated for both applications. However, no results were reported following these initial trials and development was discontinued. (en) マニファキシン(Manifaxine)は、グラクソ・スミスクラインがブプロピオンの活性代謝物であるの構造修飾によって開発した薬品である。として作用する。注意欠陥・多動性障害や肥満の治療に向けた研究が再開され、安全で効果があり、どちらの用途での使用にも耐えることが示されたが、この最初の治験の後は結果の報告がなく、現在の状況は明らかではない。 (ja)
rdfs:label	マニファキシン (ja) Manifaxine (en)
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