Horace Louis Hodes (December 21, 1907 – April 24, 1989) was an American pediatrician and infectious disease researcher. He was the first to isolate rotavirus, he demonstrated that the Japanese encephalitis virus is transmitted by mosquitoes, and he discovered that vitamin D increases intestinal absorption of calcium. He spent his early career at Johns Hopkins Hospital and later became the chief of pediatrics at Mount Sinai Hospital in Manhattan and a professor at the Icahn School of Medicine at Mount Sinai.