TYK2

TYK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3LXN, 3LXP, 3NYX, 3NZ0, 3ZON, 4GFO, 4GIH, 4GII, 4GJ2, 4GJ3, 4GVJ, 4OLI, 4PO6, 4PY1, 4WOV, 5C01, 5C03, 5F20, 5F1Z
Dynodwyr
Cyfenwau	TYK2, IMD35, JTK1, tyrosine kinase 2, Non-receptor tyrosine-protein kinase
Dynodwyr allanol	OMIM: 176941 HomoloGene: 20712 GeneCards: TYK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • type 1 angiotensin receptor binding • growth hormone receptor binding • kinase activity • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • ATP binding • non-membrane spanning protein tyrosine kinase activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • Cytosgerbwd • cnewyllyn cell Prosesau biolegol • cell differentiation • GO:0007243 intracellular signal transduction • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • protein phosphorylation • regulation of type I interferon-mediated signaling pathway • regulation of cell population proliferation • type I interferon signaling pathway • peptidyl-tyrosine autophosphorylation • innate immune response • cell migration • interleukin-12-mediated signaling pathway • peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • interleukin-23-mediated signaling pathway • interleukin-27-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7297	n/a
Ensembl	ENSG00000105397	n/a
UniProt	P29597	n/a
RefSeq (mRNA)	NM_003331	n/a
RefSeq (protein)	NP_003322	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TYK2 yw TYK2 a elwir hefyd yn Non-receptor tyrosine-protein kinase TYK2 a Tyrosine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TYK2.

• JTK1
• IMD35

Llyfryddiaeth

• "Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. ". Cancer. 2017. PMID 27875628.
• "Germline activating TYK2 mutations in pediatric patients with two primary acute lymphoblastic leukemia occurrences. ". Leukemia. 2017. PMID 27733777.
• "Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis. ". Lupus. 2016. PMID 26980740.
• "Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene. ". Cytokine. 2017. PMID 26631911.
• "Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).". J Biol Chem. 2015. PMID 26359499.