SETD2

SETD2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2A7O, 2MDC, 2MDI, 2MDJ, 4FMU, 4H12
Dynodwyr
Cyfenwau	SETD2, HBP231, HIF-1, HIP-1, HYPB, KMT3A, SET2, p231HBP, HSPC069, LLS, SET domain containing 2
Dynodwyr allanol	OMIM: 612778 HomoloGene: 56493 GeneCards: SETD2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0102674, GO:0102675 methyltransferase activity; • transferase activity; • GO:0001948, GO:0016582 protein binding; • histone-lysine N-methyltransferase activity; • protein-lysine N-methyltransferase activity; • alpha-tubulin binding; • histone methyltransferase activity (H3-K36 specific); • metal ion binding;
Cydrannau o'r gell	• nucleoplasm; • cnewyllyn cell; • Cromosom;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • histone H3-K36 dimethylation; • regulation of mRNA export from nucleus; • embryonic organ development; • stem cell development; • embryonic placenta morphogenesis; • transcription elongation from RNA polymerase II promoter; • coronary vasculature morphogenesis; • cell migration involved in vasculogenesis; • morphogenesis of a branching structure; • transcription, DNA-templated; • mesoderm morphogenesis; • vasculogenesis; • histone H3-K36 methylation; • methylation; • neural tube closure; • GO:0016584, GO:0001207, GO:0042766, GO:0001208, GO:0060303 nucleosome organization; • angiogenesis; • pericardium development; • regulation of gene expression; • histone H3-K36 trimethylation; • embryonic cranial skeleton morphogenesis; • DNA mismatch repair; • histone lysine methylation; • forebrain development; • regulation of double-strand break repair via homologous recombination; • peptidyl-lysine trimethylation; • peptidyl-lysine monomethylation; • regulation of cytokinesis; • positive regulation of interferon-alpha production; • response to type I interferon; • endodermal cell differentiation; • stem cell differentiation; • microtubule cytoskeleton organization involved in mitosis; • regulation of protein localization to chromatin; • immune system process; • GO:0100026 DNA repair; • cellular response to DNA damage stimulus; • multicellular organism development; • cell differentiation; • innate immune response; • defense response to virus; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Sources:Amigo / QuickGO
Orthologau
	29072
	n/a
	ENSG00000181555
	n/a
	Q9BYW2
	n/a
	NM_012271; NM_014159; NM_001349370
	n/a
	NP_054878; NP_001336299
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SETD2 yw SETD2 a elwir hefyd yn SET domain containing 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p21.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SETD2.

LLS
HYPB
SET2
HIF-1
HIP-1
KMT3A
HBP231
HSPC069
p231HBP

Llyfryddiaeth

"Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma. ". Oncotarget. 2016. PMID 26646321.
"SETD2 histone modifier loss in aggressive GI stromal tumours. ". Gut. 2016. PMID 26338826.
"A New Chromatin-Cytoskeleton Link in Cancer. ". Mol Cancer Res. 2016. PMID 27528705.
"Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma. ". Neoplasia. 2016. PMID 27292023.
"Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.". Leukemia. 2016. PMID 27282254.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SETD2 - Cronfa NCBI

[1]

[2]