GLRA1

GLRA1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1MOT, 1VRY, 2M6B, 2M6I, 4X5T
Dynodwyr
Cyfenwau	GLRA1, HKPX1, STHE, Glycine receptor, alpha 1, glycine receptor alpha 1
Dynodwyr allanol	OMIM: 138491 HomoloGene: 20083 GeneCards: GLRA1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• zinc ion binding; • glycine binding; • metal ion binding; • transmitter-gated ion channel activity; • extracellularly glycine-gated chloride channel activity; • GO:0001948, GO:0016582 protein binding; • extracellularly glycine-gated ion channel activity; • taurine binding; • chloride channel activity; • extracellular ligand-gated ion channel activity; • ion channel activity; • identical protein binding; • transmembrane signaling receptor activity; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cydrannau o'r gell	• integral component of membrane; • perikaryon; • postsynaptic membrane; • cell projection; • intracellular membrane-bounded organelle; • bilen; • Cellbilen; • synapse; • integral component of plasma membrane; • inhibitory synapse; • intracellular anatomical structure; • chloride channel complex; • cell junction; • dendrite; • Reticwlwm endoplasmig; • external side of plasma membrane; • neuronal cell body; • neuron projection; • calyx of Held; • glycinergic synapse; • integral component of presynaptic membrane; • integral component of postsynaptic specialization membrane;
Prosesau biolegol	• inhibitory postsynaptic potential; • muscle contraction; • startle response; • neuromuscular process controlling posture; • cellular response to ethanol; • protein heterooligomerization; • regulation of respiratory gaseous exchange; • regulation of membrane potential; • cludo ïon; • anion transport; • cellular response to zinc ion; • regulation of respiratory gaseous exchange by nervous system process; • acrosome reaction; • positive regulation of acrosome reaction; • neuromuscular process; • cellular response to amino acid stimulus; • synaptic transmission, glycinergic; • action potential; • chloride transport; • righting reflex; • neuropeptide signaling pathway; • protein homooligomerization; • negative regulation of transmission of nerve impulse; • golwg; • adult walking behavior; • chloride transmembrane transport; • response to alcohol; • excitatory postsynaptic potential; • chemical synaptic transmission; • cludo transmembrane rhwng ïonau; • GO:0072468 signal transduction; • response to amino acid; • nervous system process;
	Sources:Amigo / QuickGO
Orthologau
	2741
	n/a
	ENSG00000145888
	n/a
	P23415
	n/a
	NM_000171; NM_001146040; NM_001292000
	n/a
	NP_000162; NP_001139512; NP_001278929
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GLRA1 yw GLRA1 a elwir hefyd yn Glycine receptor alpha 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q33.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GLRA1.

STHE
HKPX1

Llyfryddiaeth

"The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site. ". J Biol Chem. 2017. PMID 28174298.
"Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor. ". Brain Res. 2017. PMID 27923639.
"Length of the TM3-4 loop of the glycine receptor modulates receptor desensitization. ". Neurosci Lett. 2015. PMID 26079326.
"Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure. ". Proc Natl Acad Sci U S A. 2015. PMID 25730860.
"Correlating structural and energetic changes in glycine receptor activation.". J Biol Chem. 2015. PMID 25572390.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GLRA1 - Cronfa NCBI

[1]

[2]