EPS15

EPS15
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1C07, 1EH2, 1F8H, 1FF1, 2IV9, 2JXC, 4RH5, 4RH9, 4RHG, 4S0G, 5JP2
Dynodwyr
Cyfenwau	EPS15, AF-1P, AF1P, MLLT5, epidermal growth factor receptor pathway substrate 15
Dynodwyr allanol	OMIM: 600051 HomoloGene: 128359 GeneCards: EPS15
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • SH3 domain binding; • metal ion binding; • polyubiquitin modification-dependent protein binding; • GO:0001948, GO:0016582 protein binding; • cadherin binding; • identical protein binding; • cargo receptor activity;
Cydrannau o'r gell	• endosome; • clathrin coat of coated pit; • early endosome membrane; • bilen; • intracellular membrane-bounded organelle; • Cellbilen; • aggresome; • ciliary membrane; • clathrin-coated pit; • AP-2 adaptor complex; • clathrin-coated vesicle; • basal plasma membrane; • apical plasma membrane; • early endosome; • cytoplasm; • cytosol; • synapse; • postsynapse; • glutamatergic synapse;
Prosesau biolegol	• negative regulation of epidermal growth factor receptor signaling pathway; • endocytosis; • epidermal growth factor receptor signaling pathway; • vesicle organization; • Golgi to endosome transport; • clathrin coat assembly; • protein transport; • viral entry into host cell; • receptor-mediated endocytosis of virus by host cell; • cell population proliferation; • positive regulation of receptor recycling; • regulation of cell population proliferation; • endocytic recycling; • membrane organization; • GO:0022415 viral process; • GO:0015915 transport; • postsynaptic neurotransmitter receptor internalization;
	Sources:Amigo / QuickGO
Orthologau
	2060
	n/a
	ENSG00000085832
	n/a
	P42566
	n/a
	NM_001159969; NM_001981
	n/a
	NP_001153441; NP_001972
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPS15 yw EPS15 a elwir hefyd yn Epidermal growth factor receptor pathway substrate 15 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p32.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPS15.

AF1P
AF-1P
MLLT5

Llyfryddiaeth

"Over-expression of EPS15 is a favorable prognostic factor in breast cancer. ". Mol Biosyst. 2015. PMID 26289382.
"UIM domain-dependent recruitment of the endocytic adaptor protein Eps15 to ubiquitin-enriched endosomes. ". BMC Cell Biol. 2014. PMID 25260758.
"Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins with acute lymphoblastic leukemia. ". Haematologica. 2012. PMID 22581003.
"Role of receptor-mediated endocytosis in the formation of vaccinia virus extracellular enveloped particles. ". J Virol. 2005. PMID 15767409.
"A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination.". J Biol Chem. 2002. PMID 12072436.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EPS15 - Cronfa NCBI

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[2]