CRKL

CRKL
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2BZX, 2BZY, 2EO3, 2LQN, 2LQW
Dynodwyr
Cyfenwau	CRKL, CRK like proto-oncogene, adaptor protein
Dynodwyr allanol	OMIM: 602007 HomoloGene: 38021 GeneCards: CRKL
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • signal transducer activity; • RNA binding; • cadherin binding; • phosphotyrosine residue binding; • identical protein binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • endosome; • extracellular exosome; • nucleoplasm; • neuromuscular junction; • GO:0009327 protein-containing complex; • synapse; • extrinsic component of postsynaptic membrane;
Prosesau biolegol	• animal organ morphogenesis; • pattern specification process; • JNK cascade; • heart development; • Ras protein signal transduction; • GO:0007243 intracellular signal transduction; • blood vessel development; • parathyroid gland development; • anterior/posterior pattern specification; • positive regulation of cell population proliferation; • thymus development; • positive regulation of substrate adhesion-dependent cell spreading; • regulation of cell growth; • urogenital system development; • neuron migration; • B cell apoptotic process; • GO:0033128 negative regulation of protein phosphorylation; • positive regulation of protein phosphorylation; • regulation of leukocyte migration; • outflow tract morphogenesis; • lipid metabolism; • spermatogenesis; • single fertilization; • synapse assembly; • fibroblast growth factor receptor signaling pathway; • male gonad development; • regulation of gene expression; • negative regulation of gene expression; • dendrite development; • cytokine-mediated signaling pathway; • hippocampus development; • cerebral cortex development; • establishment of cell polarity; • regulation of cell adhesion mediated by integrin; • helper T cell diapedesis; • reelin-mediated signaling pathway; • positive regulation of Ras protein signal transduction; • retinoic acid receptor signaling pathway; • regulation of dendrite development; • T cell receptor signaling pathway; • cell chemotaxis; • pharynx development; • positive regulation of ERK1 and ERK2 cascade; • cellular response to transforming growth factor beta stimulus; • response to fibroblast growth factor; • endothelin receptor signaling pathway; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • acetylcholine receptor signaling pathway; • cerebellar neuron development; • cellular response to interleukin-7; • positive regulation of glial cell migration; • regulation of skeletal muscle acetylcholine-gated channel clustering; • cranial skeletal system development; • regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologau
	1399
	n/a
	ENSG00000099942
	n/a
	P46109
	n/a
	NM_005207
	n/a
	NP_005198
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CRKL yw CRKL a elwir hefyd yn CRK like proto-oncogene, adaptor protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q11.21.^[2]

Llyfryddiaeth

"Reduction of CRKL expression in patients with partial DiGeorge syndrome is associated with impairment of T-cell functions. ". J Allergy Clin Immunol. 2016. PMID 26875746.
"CrkL meditates CCL20/CCR6-induced EMT in gastric cancer. ". Cytokine. 2015. PMID 26044596.
"The role of CT10 regulation of kinase-like in cancer. ". Future Oncol. 2014. PMID 25531052.
"CrkL regulates SDF-1-induced breast cancer biology through balancing Erk1/2 and PI3K/Akt pathways. ". Med Oncol. 2015. PMID 25476480.
"CRKL protein overexpression enhances cell proliferation and invasion in pancreatic cancer.". Tumour Biol. 2015. PMID 25318601.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CRKL - Cronfa NCBI

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[2]