NR1H4

NR1H4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1OSH, 3BEJ, 3DCT, 3DCU, 3FLI, 3FXV, 3GD2, 3HC5, 3HC6, 3L1B, 3OKH, 3OKI, 3OLF, 3OMK, 3OMM, 3OOF, 3OOK, 3RUT, 3RUU, 3RVF, 3P88, 3P89, 4OIV, 4WVD, 4QE6, 4QE8
Dynodwyr
Cyfenwau	NR1H4, BAR, FXR, HRR-1, HRR1, RIP14, nuclear receptor subfamily 1 group H member 4, PFIC5
Dynodwyr allanol	OMIM: 603826 HomoloGene: 3760 GeneCards: NR1H4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • sequence-specific DNA binding; • DNA binding; • GO:0001106 transcription corepressor activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001105 transcription coactivator activity; • zinc ion binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • metal ion binding; • retinoid X receptor binding; • steroid hormone receptor activity; • bile acid binding; • GO:0001948, GO:0016582 protein binding; • nuclear receptor binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • chenodeoxycholic acid binding; • GO:0000975 transcription cis-regulatory region binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • bile acid receptor activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor binding; • nuclear receptor coactivator activity; • signaling receptor activity;
Cydrannau o'r gell	• nucleoplasm; • cnewyllyn cell; • RNA polymerase II transcription regulator complex;
Prosesau biolegol	• Notch signaling pathway; • cellular triglyceride homeostasis; • cellular response to organonitrogen compound; • regulation of insulin secretion involved in cellular response to glucose stimulus; • positive regulation of ammonia assimilation cycle; • toll-like receptor 4 signaling pathway; • immune system process; • histone H3-R17 methylation; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • positive regulation of glutamate metabolic process; • intracellular bile acid receptor signaling pathway; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • regulation of low-density lipoprotein particle clearance; • regulation of bile acid biosynthetic process; • regulation of cholesterol metabolic process; • regulation of urea metabolic process; • intracellular receptor signaling pathway; • negative regulation of bile acid biosynthetic process; • cellular response to fatty acid; • bile acid and bile salt transport; • nitrogen catabolite activation of transcription from RNA polymerase II promoter; • transcription initiation from RNA polymerase II promoter; • inflammatory response; • innate immune response; • GO:0072468 signal transduction; • steroid hormone mediated signaling pathway; • fatty acid homeostasis; • GO:1903106 positive regulation of insulin receptor signaling pathway; • cellular response to lipopolysaccharide; • negative regulation of interleukin-2 production; • positive regulation of insulin secretion involved in cellular response to glucose stimulus; • negative regulation of inflammatory response; • glucose homeostasis; • negative regulation of NF-kappaB transcription factor activity; • positive regulation of adipose tissue development; • cell-cell junction assembly; • toll-like receptor 9 signaling pathway; • negative regulation of monocyte chemotactic protein-1 production; • bile acid metabolic process; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • negative regulation of tumor necrosis factor-mediated signaling pathway; • defense response to bacterium; • negative regulation of interleukin-1 production; • negative regulation of tumor necrosis factor production; • negative regulation of interleukin-6 production; • triglyceride homeostasis; • negative regulation of interferon-gamma production; • GO:0009373 regulation of transcription, DNA-templated; • bile acid signaling pathway; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of phosphatidic acid biosynthetic process; • cholesterol homeostasis; • lipid metabolism; • multicellular organism development; • cell differentiation; • lipid homeostasis; • cellular glucose homeostasis;
	Sources:Amigo / QuickGO
Orthologau
	9971
	n/a
	ENSG00000012504
	n/a
	Q96RI1
	n/a
NM_001206977; NM_001206978; NM_001206979; NM_001206992; NM_001206993;
	NM_005123
	n/a
NP_001193906; NP_001193907; NP_001193908; NP_001193921; NP_001193922;
	NP_005114; NP_001193906.1; NP_001193908.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR1H4 yw NR1H4 a elwir hefyd yn Farnesoid X nuclear receptor a Nuclear receptor subfamily 1 group H member 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q23.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR1H4.

BAR
FXR
HRR1
HRR-1
PFIC5
RIP14

Llyfryddiaeth

"Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets. ". Arterioscler Thromb Vasc Biol. 2017. PMID 28619996.
"Farnesoid X receptor regulates the growth of renal adenocarcinoma cells without affecting that of a normal renal cell-derived cell line. ". J Toxicol Sci. 2017. PMID 28496032.
"Reciprocal regulation of farnesoid X receptor α activity and hepatitis B virus replication in differentiated HepaRG cells and primary human hepatocytes. ". FASEB J. 2016. PMID 27251172.
"Farnesoid X Receptor Expression Reduced in Obese Rat Model With Insulin Resistance. ". Am J Med Sci. 2015. PMID 26488943.
"Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.". Sci Rep. 2014. PMID 25257666.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NR1H4 - Cronfa NCBI

[2]

[1]