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Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage
/ Small, K L (Manchester U. ; Daresbury) ; Henthorn, N T (Manchester U. ; Unlisted, GB) ; Angal-Kalinin, D (Manchester U. ; Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Chadwick, A L (Manchester U. ; Unlisted, GB) ; Santina, E (Manchester U. ; Unlisted, GB) ; Aitkenhead, A (Manchester U. ; Unlisted, GB) ; Kirkby, K J (Manchester U. ; Unlisted, GB) ; Smith, R J (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Surman, M (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Jones, J (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) et al.
This paper presents the first plasmid DNA irradiations carried out with Very High Energy Electrons (VHEE) over 100–200 MeV at the CLEAR user facility at CERN to determine the Relative Biological Effectiveness (RBE) of VHEE. DNA damage yields were measured in dry and aqueous environments to determine that ~ 99% of total DNA breaks were caused by indirect effects, consistent with other published measurements for protons and photons. [...]
2021 - 12 p.
- Published in : Sci. Rep. 11 (2021) 3341
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EuPRAXIA Conceptual Design Report
/ Assmann, R W (DESY) ; Weikum, M K (DESY) ; Akhter, T (INFN, Naples) ; Alesini, D (Frascati) ; Alexandrova, A S (Cockcroft Inst. Accel. Sci. Tech. ; U. Liverpool (main)) ; Anania, M P (Frascati) ; Andreev, N E (ITAE, Moscow ; Moscow, MIPT) ; Andriyash, I (Weizmann Inst.) ; Artioli, M (ENEA, Bologna) ; Aschikhin, A (DESY) et al.
This report presents the conceptual design of a new European research infrastructure EuPRAXIA. The concept has been established over the last four years in a unique collaboration of 41 laboratories within a Horizon 2020 design study funded by the European Union. [...]
2020 - 610 p.
- Published in : Eur. Phys. J. Spec. Top. 229 (2020) 3675-4284
- Published in : Eur. Phys. J. Spec. Top. 229 (2020) 11-31
Fulltext from Publisher: PDF;
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CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications
/ Whitmore, L (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech. ; Texas U., Houston) ; Mackay, R I (Manchester U.) ; van Herk, M (Manchester U.) ; Korysko, P (Oxford U. ; CERN) ; Farabolini, W (CERN) ; Malyzhenkov, A (CERN) ; Corsini, R (CERN) ; Jones, R M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. [...]
2024 - 15 p.
- Published in : Sci. Rep. 14 (2024) 11120
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Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN
/ Webster, Ben (Teddington, Natl. Phys. Lab ; Surrey U.) ; Ivanov, Peter (Teddington, Natl. Phys. Lab) ; Russell, Ben (Teddington, Natl. Phys. Lab) ; Collins, Sean (Teddington, Natl. Phys. Lab) ; Stora, Thierry (CERN) ; Ramos, Joao Pedro (CERN ; Leuven U.) ; Köster, Ulli (Laue-Langevin Inst.) ; Robinson, Andrew Paul (Teddington, Natl. Phys. Lab ; Manchester U.) ; Read, David (Teddington, Natl. Phys. Lab ; Surrey U.)
Four terbium radioisotopes ($^{149, 152, 155, 161}$Tb) constitute a potential theranostic quartet for cancer treatment but require any derived radiopharmaceutical to be essentially free of impurities. Terbium-155 prepared by proton irradiation and on-line mass separation at the CERN-ISOLDE and CERN-MEDICIS facilities contains radioactive$^{139}$Ce$^{16}$O and also zinc or gold, depending on the catcher foil used. [...]
2019
- Published in : Sci. Rep. 9 (2019) 10884
fulltext from publisher: PDF;
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Influence of heterogeneous media on Very High Energy Electron (VHEE) dose penetration and a Monte Carlo-based comparison with existing radiotherapy modalities
/ Lagzda, Agnese (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.) ; Angal-Kalinin, Deepa (Cockcroft Inst. Accel. Sci. Tech. ; Daresbury) ; Jones, James (Cockcroft Inst. Accel. Sci. Tech. ; Daresbury) ; Aitkenhead, Adam (Unlisted, UK ; Manchester U.) ; Kirkby, Karen J (Unlisted, UK ; Manchester U.) ; MacKay, Ranald (Unlisted, UK ; Manchester U.) ; Van Herk, Marcel (Unlisted, UK ; Manchester U.) ; Farabolini, Wilfrid (CERN) ; Zeeshan, Sumaira (CERN) ; Jones, Roger M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
• First experimental demonstration of the relative insensitivity of VHEE beams to inhomogeneities. • Topas/GEANT4 simulations on experiments conducted at CERN’s CLEAR facility are in good agreement. [...]
2020 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., B 482 (2020) 70-81
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Observation of the 1S–2P Lyman-$\alpha$ transition in antihydrogen
/ Ahmadi, M (Liverpool U.) ; Alves, B X R (Aarhus U.) ; Baker, C J (Swansea U.) ; Bertsche, W (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.) ; Capra, A (TRIUMF) ; Carruth, C (UC, Berkeley) ; Cesar, C L (Rio de Janeiro Federal U.) ; Charlton, M (Swansea U.) ; Cohen, S (Ben Gurion U. of Negev) ; Collister, R (TRIUMF) et al.
/ALPHA
In 1906, Theodore Lyman discovered his eponymous series of transitions in the extreme-ultraviolet region of the atomic hydrogen spectrum1,2. The patterns in the hydrogen spectrum helped to establish the emerging theory of quantum mechanics, which we now know governs the world at the atomic scale. [...]
2018 - 5 p.
- Published in : Nature 561 (2018) 211-215
Fulltext: PDF; External link: Interactions.org article
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CIRCUS: an autonomous control system for antimatter, atomic and quantum physics experiments
/ AEgIS Collaboration
A powerful and robust control system is a crucial, often neglected, pillar of any modern, complex physics experiment that requires the management of a multitude of different devices and their precise time synchronisation. The AEgIS collaboration presents CIRCUS, a novel, autonomous control system optimised for time-critical experiments such as those at CERN's Antiproton Decelerator and, more broadly, in atomic and quantum physics research. [...]
arXiv:2402.04637.-
2024-02-15 - 35 p.
- Published in : EPJ Quant. Technol. 11 (2024) 10
Fulltext: document - PDF; 2402.04637 - PDF;
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Sympathetic cooling of positrons to cryogenic temperatures for antihydrogen production
/ Baker, C J (Swansea U.) ; Bertsche, W (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech. ; Liverpool U.) ; Capra, A (TRIUMF) ; Cesar, C L (Rio de Janeiro Federal U.) ; Charlton, M (Swansea U.) ; Mathad, A Cridland (Swansea U.) ; Eriksson, S (Swansea U.) ; Evans, A (Calgary U.) ; Evetts, N (British Columbia U.) ; Fabbri, S (Manchester U.) et al.
The positron, the antiparticle of the electron, predicted by Dirac in 1931 and discovered by Anderson in 1933, plays a key role in many scientific and everyday endeavours. Notably, the positron is a constituent of antihydrogen, the only long-lived neutral antimatter bound state that can currently be synthesized at low energy, presenting a prominent system for testing fundamental symmetries with high precision. [...]
2021 - 8 p.
- Published in : Nature Commun. 12 (2021) 6139
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Characterization of the 1S–2S transition in antihydrogen
/ Ahmadi, M (Liverpool U.) ; Alves, B X R (Aarhus U.) ; Baker, C J (Swansea U.) ; Bertsche, W (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.) ; Capra, A (TRIUMF) ; Carruth, C (UC, Berkeley) ; Cesar, C L (Rio de Janeiro Federal U.) ; Charlton, M (Swansea U.) ; Cohen, S (Ben Gurion U. of Negev) ; Collister, R (TRIUMF) et al.
In 1928, Dirac published an equation that combined quantum mechanics and special relativity. Negative-energy solutions to this equation, rather than being unphysical as initially thought, represented a class of hitherto unobserved and unimagined particles—antimatter. [...]
2018 - 5 p.
- Published in : Nature 557 (2018) 71-75
Fulltext: s41586-018-0017-2 - PDF; 10.1038_s41586-018-0017-2 - PDF; External link: INTERACTIONS
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