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Evaluation of GATE‐RTion (GATE/Geant4) Monte Carlo simulation settings for proton pencil beam scanning quality assurance / Winterhalter, Carla (Manchester U.) ; Taylor, Michael (Manchester U.) ; Boersma, David (Unlisted, AT) ; Elia, Alessio (Unlisted, AT) ; Guatelli, Susanna (Wollongong U.) ; Mackay, Ranald (Manchester U.) ; Kirkby, Karen (Manchester U.) ; Maigne, Lydia (Clermont-Ferrand U.) ; Ivanchenko, Vladimir (CERN ; Tomsk State U.) ; Resch, Andreas F (Vienna U.) et al.
Purpose Geant4 is a multi‐purpose Monte Carlo simulation tool for modeling particle transport in matter. It provides a wide range of settings, which the user may optimize for their specific application. [...]
2020 - 11 p. - Published in : Med. Phys. 47 (2020) 5817-5828

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Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage / Small, K L (Manchester U. ; Daresbury) ; Henthorn, N T (Manchester U. ; Unlisted, GB) ; Angal-Kalinin, D (Manchester U. ; Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Chadwick, A L (Manchester U. ; Unlisted, GB) ; Santina, E (Manchester U. ; Unlisted, GB) ; Aitkenhead, A (Manchester U. ; Unlisted, GB) ; Kirkby, K J (Manchester U. ; Unlisted, GB) ; Smith, R J (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Surman, M (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Jones, J (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) et al.
This paper presents the first plasmid DNA irradiations carried out with Very High Energy Electrons (VHEE) over 100–200 MeV at the CLEAR user facility at CERN to determine the Relative Biological Effectiveness (RBE) of VHEE. DNA damage yields were measured in dry and aqueous environments to determine that ~ 99% of total DNA breaks were caused by indirect effects, consistent with other published measurements for protons and photons. [...]
2021 - 12 p. - Published in : Sci. Rep. 11 (2021) 3341 Fulltext from publisher: PDF;

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Influence of heterogeneous media on Very High Energy Electron (VHEE) dose penetration and a Monte Carlo-based comparison with existing radiotherapy modalities / Lagzda, Agnese (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.) ; Angal-Kalinin, Deepa (Cockcroft Inst. Accel. Sci. Tech. ; Daresbury) ; Jones, James (Cockcroft Inst. Accel. Sci. Tech. ; Daresbury) ; Aitkenhead, Adam (Unlisted, UK ; Manchester U.) ; Kirkby, Karen J (Unlisted, UK ; Manchester U.) ; MacKay, Ranald (Unlisted, UK ; Manchester U.) ; Van Herk, Marcel (Unlisted, UK ; Manchester U.) ; Farabolini, Wilfrid (CERN) ; Zeeshan, Sumaira (CERN) ; Jones, Roger M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
• First experimental demonstration of the relative insensitivity of VHEE beams to inhomogeneities. • Topas/GEANT4 simulations on experiments conducted at CERN’s CLEAR facility are in good agreement. [...]
2020 - 12 p. - Published in : Nucl. Instrum. Methods Phys. Res., B 482 (2020) 70-81

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Very-High Energy Electron (VHEE) Studies at CERN's CLEAR User Facility / Lagzda, Agnese (U. Manchester (main) ; Cockcroft Inst. Accel. Sci. Tech.) ; Aitkenhead, Adam (Manchester U.) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Jones, Roger (U. Manchester (main) ; Cockcroft Inst. Accel. Sci. Tech.) ; Kirkby, Karen (U. Manchester (main) ; Cockcroft Inst. Accel. Sci. Tech. ; Manchester U.) ; MacKay, Ranald (Manchester U. ; U. Manchester (main)) ; Van Herk, Marcel (Manchester U.)
Here we investigate how inserts of various densities (0.001-2.2 g/cm³) affect the dose distribution properties of VHEE beams at ~150 MeV. A range variation comparison was also made with clinical proton beams using TOPAS/GEANT4 Monte Carlo simulations. [...]
2018 - 4 p. - Published in : 10.18429/JACoW-IPAC2018-MOPML023 Fulltext: PDF;
In : 9th International Particle Accelerator Conference, Vancouver, Canada, 29 Apr - 4 May 2018, pp.MOPML023

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