CERN Accelerating science

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Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage / Small, K L (Manchester U. ; Daresbury) ; Henthorn, N T (Manchester U. ; Unlisted, GB) ; Angal-Kalinin, D (Manchester U. ; Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Chadwick, A L (Manchester U. ; Unlisted, GB) ; Santina, E (Manchester U. ; Unlisted, GB) ; Aitkenhead, A (Manchester U. ; Unlisted, GB) ; Kirkby, K J (Manchester U. ; Unlisted, GB) ; Smith, R J (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Surman, M (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Jones, J (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) et al.
This paper presents the first plasmid DNA irradiations carried out with Very High Energy Electrons (VHEE) over 100–200 MeV at the CLEAR user facility at CERN to determine the Relative Biological Effectiveness (RBE) of VHEE. DNA damage yields were measured in dry and aqueous environments to determine that ~ 99% of total DNA breaks were caused by indirect effects, consistent with other published measurements for protons and photons. [...]
2021 - 12 p. - Published in : Sci. Rep. 11 (2021) 3341 Fulltext from publisher: PDF;

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