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1.
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Element-specific spectral imaging of multiple contrast agents: a phantom study
/ Panta, R K (U. Otago, Dept. Radiol. ; MARS Bioimaging) ; Bell, S T (MARS Bioimaging) ; Healy, J L (Canterbury U.) ; Aamir, R (U. Otago, Dept. Radiol. ; MARS Bioimaging) ; Bateman, C J (Lincoln University) ; Moghiseh, M (U. Otago, Dept. Radiol.) ; Butler, A P H (CERN ; U. Otago, Dept. Radiol. ; MARS Bioimaging ; Canterbury U.) ; Anderson, N G (U. Otago, Dept. Radiol.)
This work demonstrates the feasibility of simultaneous discrimination of multiple contrast agents based on their element-specific and energy-dependent X-ray attenuation properties using a pre-clinical photon-counting spectral CT. We used a photon-counting based pre-clinical spectral CT scanner with four energy thresholds to measure the X-ray attenuation properties of various concentrations of iodine (9, 18 and 36 mg/ml), gadolinium (2, 4 and 8 mg/ml) and gold (2, 4 and 8 mg/ml) based contrast agents, calcium chloride (140 and 280 mg/ml) and water. [...]
2018 - 17 p.
- Published in : JINST 13 (2018) T02001-T02001
Fulltext: PDF;
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2.
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MARS-MD: rejection based image domain material decomposition
/ Bateman, C.J. (MARS Bioimaging ; U. Otago, Dept. Radiol. ; Canterbury U. ; Lincoln Agritech Limited, New Zealand) ; Knight, D. (U. Otago, Dept. Radiol.) ; Brandwacht, B. (Twente U., Enschede) ; Mahon, J., MC (Canterbury U.) ; Healy, J. (U. Canterbury, Dept. Biol.) ; Panta, R. (U. Otago, Dept. Radiol. ; MARS Bioimaging) ; Aamir, R. (U. Otago, Dept. Radiol.) ; Rajendran, K. (U. Otago, Dept. Radiol.) ; Moghiseh, M. (U. Otago, Dept. Radiol.) ; Ramyar, M. (U. Otago, Dept. Radiol.) et al.
This paper outlines image domain material decomposition algorithms that have been routinely used in MARS spectral CT systems. These algorithms (known collectively as MARS-MD) are based on a pragmatic heuristic for solving the under-determined problem where there are more materials than energy bins. [...]
arXiv:1802.05366.-
2018-03-16
- Published in : JINST 13 (2018) P05020-P05020
Preprint: arXiv:1802.05366 - PDF; 10.1088.1748-0221.13.05.P05020 - PDF;
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3.
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Semi-analytic off-axis X-ray source model
/ Shamshad, M (U. Otago, Dept. Radiol.) ; Anjomrouz, M (U. Otago, Dept. Radiol.) ; Smithies, D J (MARS Bioimaging) ; Largeau, A (Telecom Phys., Strasbourg) ; Lu, G (Canterbury U.) ; Atharifard, A (U. Otago, Dept. Radiol.) ; Vanden Broeke, L (Canterbury U.) ; Aamir, R (U. Otago, Dept. Radiol. ; MARS Bioimaging) ; Panta, R K (U. Otago, Dept. Radiol. ; MARS Bioimaging) ; Walsh, M F (MARS Bioimaging) et al.
Spectral computed tomography (CT) systems are employed with energy-resolving photon counting detectors. Incorporation of a spectrally accurate x-ray beam model in image reconstruction helps to improve material identification and quantification by these systems. [...]
2017
- Published in : JINST 12 (2017) P10013
External link: Fulltext
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4.
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Per-pixel energy calibration of photon counting detectors
/ Atharifard, A (Otago U.) ; Healy, J L (Canterbury U.) ; Goulter, B P (MARS Center) ; Ramyar, M (Otago U.) ; Broeke, L Vanden (Canterbury U.) ; Walsh, M F ; Onyema, C C (Canterbury U.) ; Panta, R K (Otago U.) ; Aamir, R (Otago U.) ; Smithies, D J et al.
Energy resolving performance of spectral CT systems is influenced by the accuracy of the detector's energy calibration. Global energy calibration maps a given threshold to the average energy response of all pixels of the detector. [...]
2017 - 12 p.
- Published in : JINST 12 (2017) C03085
Fulltext: pdf - PDF; 10.1088_1748-0221_12_03_C03085 - PDF;
In : 18th International Workshop on Radiation Imaging Detectors, Barcelona, Spain, 03 - 07 Jul 2016, pp.C03085
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5.
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Quantitative imaging of excised osteoarthritic cartilage using spectral CT
/ Rajendran, Kishore (Otago U.) ; Löbker, Caroline (Otago U.) ; Schon, Benjamin S (Twente U., Enschede) ; Bateman, Christopher J (Otago U.) ; Younis, Raja Aamir (Otago U.) ; de Ruiter, Niels J A (Otago U.) ; Chernoglazov, Alex I (Canterbury U.) ; Ramyar, Mohsen (Otago U.) ; Hooper, Gary J (Otago U.) ; Butler, Anthony P H (Otago U. ; CERN ; MARS Bioimaging, New Zealand) et al.
Objectives:
To quantify iodine uptake in articular cartilage as a marker of glycosaminoglycan (GAG) content using multi-energy spectral CT.
Methods:
We incubated a 25-mm strip of excised osteoarthritic human tibial plateau in 50 % ionic iodine contrast and imaged it using a small-animal spectral scanner with a cadmium telluride photon-processing detector to quantify the iodine through the thickness of the articular cartilage. We imaged both spectroscopic phantoms and osteoarthritic tibial plateau samples. [...]
2017 - 9 p.
- Published in : Eur. Radiol. 27 (2017) 384-392
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6.
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Oblique fluorescence in a MARS scanner with a CdTe-Medipix3RX
/ Broeke, L Vanden (Canterbury U.) ; Atharifard, A. (Unlisted, NZ) ; Goulter, B.P. (Unlisted, NZ) ; Healy, J.L. (Unlisted, NZ) ; Ramyar, M. (Unlisted, NZ) ; Panta, R.K. (Unlisted, NZ ; Unlisted, NZ) ; Anjomrouz, M. (Unlisted, NZ) ; Shamshad, M. (Unlisted, NZ) ; Largeau, A. (Telecom Phys., Strasbourg) ; Mueller, K. (Lubeck, Fachhochschule) et al.
The latest version of the MARS small bore scanner makes use of the Medipix3RX ASIC, bonded to a CdTe or CZT semi-conductor layer, to count x-ray photons and create a spectroscopic CT data set. The MARS imaging chain uses the energy-resolved 2D transmission images to construct quantitative 3D spectral and material images. [...]
2016
- Published in : JINST 11 (2016) C12063
IOP Open Access article: PDF;
In : 18th International Workshop on Radiation Imaging Detectors, Barcelona, Spain, 03 - 07 Jul 2016, pp.C12063
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7.
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Spectral CT data acquisition with Medipix3.1
/ Walsh, M F (U. Otago Christchurch) ; Nik, S J (Canterbury U.) ; Procz, S (U. Freiburg, FMF) ; Pichotka, M (U. Freiburg, FMF) ; Bell, S T (MARS BioImaging Ltd, Christchurch) ; Bateman, C J (U. Otago Christchurch) ; Doesburg, R M N (Canterbury U.) ; De Ruiter, N (U. Otago Christchurch) ; Chernoglazov, A I (Canterbury U.) ; Panta, R K (U. Otago Christchurch) et al.
2013
- Published in : JINST 8 (2013) P10012
IOP Open Access article: PDF;
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8.
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Reducing beam hardening effects and metal artefacts using Medipix3RX: With applications from biomaterial science
/ Rajendran, K. ; Walsh, M.F. ; de Ruiter, N.J.A. ; Chernoglazov, A.I. ; Panta, R.K. ; Butler, A.P.H. ; Butler, P.H. ; Bell, S.T. ; Anderson, N.G. ; Woodfield, T.B.F. et al.
This paper discusses methods for reducing beam hardening effects using spectral data for biomaterial applications. A small-animal spectral scanner operating in the diagnostic energy range was used. [...]
arXiv:1311.5303.-
2014-03-26 - 11 p.
- Published in : JINST 9 (2014) P03015
Preprint: PDF; External link: Preprint
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9.
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MARS spectral molecular imaging of lamb tissue: data collection and image analysis
/ Aamir, R. (Otago U.) ; Chernoglazov, A. (Canterbury U.) ; Bateman, C.J. (Otago U.) ; Butler, A.P.H. (Otago U. ; CERN ; Canterbury U.) ; Butler, P.H. (CERN ; Canterbury U.) ; Anderson, N.G. (Otago U.) ; Bell, S.T. (Unlisted, NZ) ; Panta, R.K. (Otago U.) ; Healy, J.L. (Canterbury U.) ; Mohr, J.L. (Otago U.) et al.
Spectral molecular imaging is a new imaging technique able to discriminate and quantify different components of tissue simultaneously at high spatial and high energy resolution. Our MARS scanner is an x-ray based small animal CT system designed to be used in the diagnostic energy range (20 to 140 keV). [...]
arXiv:1311.4528.-
2014-02-17 - 11 p.
- Published in : JINST 9 (2014) P02005
Fulltext: PDF; IOP Open Access article: PDF; External link: Preprint
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