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A systematic investigation of beam losses and position reconstruction techniques measured with a novel oBLM at CLEAR
/ King, Montague (CERN ; Liverpool U.) ; Christie, Alexander (Oxford U.) ; Salvachua, Belen (CERN) ; Welsch, Carsten (Liverpool U.) ; Effinger, Ewald (CERN) ; Meyer, Jean Michel (CERN) ; Esteban Felipe, Jose (CERN) ; Wolfenden, Joseph (Cockcroft Inst. Accel. Sci. Tech.) ; Korysko, Pierre (Oxford U.) ; Benitez, Sara (CERN) et al.
Optical Beam Loss Monitors (oBLMs) allow for cost-efficient and spatially continuous measurements of beam losses at accelerator facilities. A standard oBLM consists of several tens of meters of optical fibre aligned parallel to the beamline, coupled to photosensors at either or both ends. [...]
2024 - 5 p.
- Published in : JACoW IBIC 2024 (2024) FRBC2
Fulltext: PDF;
In : 13th International Beam Instrumentation Conference (IBIC 2024), Beijing, China, 9-13 Sep 2024, pp.FRBC2
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2.
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Spatially fractionated radiotherapy with very high energy electron pencil beam scanning
/ Fischer, Jade (Victoria U.) ; Hart, Alexander (Victoria U.) ; Bedriová, Nicole (Zilina U.) ; Krim, Deae-eddine (Victoria U.) ; Clements, Nathan (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (Oslo U.) ; Corsini, Roberto (CERN) et al.
Objective. To evaluate spatially fractionated radiation therapy (SFRT) for very-high-energy electrons (VHEEs) delivered with pencil beam scanning. [...]
2024 - 12 p.
- Published in : Phys. Med. Biol. 70 (2025) 015011
Fulltext: PDF;
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3.
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Medical activities in CLEAR: studies towards radiotherapy using Very High Energy Electrons (VHEE) in the FLASH regime
/ Corsini, Roberto (CERN) ; Malyzhenkov, Alexander (CERN) ; Gilardi, Antonio (Naples U. ; INFN, Naples) ; Aksoy, Avni (CERN) ; Robertson, Cameron (Oxford U.) ; Bateman, Joseph (Oxford U.) ; Dosanjh, Manjit (CERN) ; Korysko, Pierre (Oxford U.) ; Rieker, Vilde (CERN) ; Farabolini, Wilfrid (CERN)
Given the present availability of high-gradient accelerator technology for compact and cost-effective electron linacs in the 100-200 MeV energy range, the interest for Very High Energy Electron (VHEE) radiotherapy (RT) for cancer treatment recently reached an all-time high. Particular significance is assumed by the Ultra-High Dose Rate (UHDR) regime where the so-called FLASH biological effect takes place, in which cancer cells are damaged while healthy tissue is largely spared. [...]
2024 - 4 p.
- Published in : JACoW LINAC 2024 (2024) THPB018
Fulltext: PDF;
In : 32nd Linear Accelerator Conference (LINAC 2024), Chicago, Illinois, United States, 25 - 30 Aug 2024, pp.THPB018
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4.
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5.
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Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements
/ Rieker, Vilde F (CERN ; Oslo U.) ; Corsini, Roberto (CERN) ; Stapnes, Steinar (CERN) ; Adli, Erik (Oslo U.) ; Farabolini, Wilfrid (CERN) ; Grilj, Veljko (SUBATECH, Nantes) ; Sjobak, Kyrre N (Oslo U.) ; Wroe, Laurence M (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Robertson, Cameron S (Oxford U.) et al.
The discovery of the FLASH effect has revealed a high potential for treating cancer more efficiently by sparing
healthy tissue. The surge in related medical research activities over the last couple of years has triggered a
demand for technology with the capability of generating and measuring ionizing radiation at ultra-high doserates (UHDR). [...]
2024 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 1069 (2024) 169845
Fulltext: PDF;
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6.
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Bubble-beam accelerators: breaking the paradigm
/ Malyzhenkov, Alexander (CERN) ; Latina, Andrea (CERN) ; Dyks, Luke (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Korysko, Pierre (JAI, UK ; CERN) ; Burrows, Philip (JAI, UK) ; Tranchedone, Lorenzo (JAI, UK ; CERN)
Most particle accelerators utilize beams with a charge density concentrated in the center of the bunch in real 3-dimensional space and the 6-dimensional phase space. In this work, by enhancing the space-charge forces in the photo-cathode injector of the Compact Linear Electron Accelerator for Research (CLEAR) at CERN, we produce electron bunches with a “bubble-like” shape, with a charge density mostly concentrated on the outside shell. [...]
2024 - 4 p.
- Published in : JACoW IPAC 2024 (2024) WEPC03
Fulltext: PDF;
In : 15th International Particle Accelerator Conference (IPAC 2024), Nashville, TN, United States, 19 - 24 May 2024, pp.WEPC03
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7.
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Application of beam-based alignment to the CLEAR facility
/ Aksoy, Avni (Ankara U. ; CERN) ; Malyzhenkov, Alexander (CERN) ; Latina, Andrea (CERN) ; Korysko, Pierre (Oxford U. ; CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN)
The CERN Linear Electron Accelerator for Research (CLEAR) has been operating since 2017 as a user facility providing beams for a large variety of experiments. Its RF photocathode-based linear accelerator can accelerate electrons up to 220 MeV with a bunch charge of 0.1-1.5nC with single or up to 150 bunches per train. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) WEPL025
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.WEPL025
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Real-time Plastic Scintillation Dosimetry of Ultra-High Dose Rate Very High Energy Electrons (VHEE) at CERN CLEAR Facility
/ Giguère, Cloé (Laval U.) ; Hart, Alexander (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfrid (CERN) ; LeChasseur, Yoan (McGill U.) ; Bazalova-Carter, Magdalena (Victoria U.) ; Beaulieu, Luc (Laval U.)
Very High Energy Electrons (VHEE) that can theoretically treat deep-seated tumours and be delivered at ultra-high dose rates (UHDR) could be the solution to translate FLASH radiotherapy into the clinic. Standard dosimeters have limited application in those extreme conditions, but dose-rate independent and fast-response plastic scintillation detectors (PSDs) are a potential alternative to overcome this. [...]
2024 - 4 p.
- Published in : J. Phys. : Conf. Ser. 2799 (2024) 012016
Fulltext: PDF;
In : 13th International Conference on 3D dosimetry (IC3DDose 2024), Aarhus, Denmark, 17 - 19 Jun 2024, pp.012016
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9.
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Plastic Scintillator Dosimetry of Ultrahigh Dose-Rate 200 MeV Electrons at CLEAR
/ Hart, Alexander (Victoria U.) ; Giguère, Cloé (Laval U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Esplen, Nolan (Victoria U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (Oxford U.) ; Beaulieu, Luc (Laval U.) et al.
Very-high-energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favorable dose distributions and accessibility of ultrahigh dose rates (UHDRs). Combining VHEE with the normal tissue-sparing FLASH effect of UHDR radiotherapy could improve patient outcomes. [...]
2024 - 9 p.
- Published in : IEEE Sensors J. 24 (2024) 14229-14237
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10.
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Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates
/ Bateman, Joseph J (JAI, UK) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Korysko, Pierre (JAI, UK ; CERN) ; Larsen, Robert Garbrecht (CERN ; Groningen U.) ; Malyzhenkov, Alexander (CERN) ; Ruiz, Iñaki Ortega (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Gerbershagen, Alexander (Groningen U.)
Objective. Very high energy electrons (VHEE) in the range of 50–250 MeV are of interest for treating deep-seated tumours with FLASH radiotherapy (RT). [...]
2024 - 16 p.
- Published in : Phys. Med. Biol. 69 (2024) 085006
Fulltext: PDF;
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