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Preparation and in vivo evaluation of red blood cell membrane coated porous silicon nanoparticles implanted with $^{155}$Tb / Jakobsson, Ulrika (Helsinki Inst. of Phys.) ; Mäkilä, Ermei (Turku U.) ; Rahikkala, Antti (Helsinki U.) ; Imlimthan, Surachet (Helsinki U.) ; Lampuoti, Jarkko (Helsinki U.) ; Ranjan, Sanjeev (Helsinki U. ; UEF, Kuopio) ; Heino, Jouni (Helsinki Inst. of Phys.) ; Jalkanen, Pasi (Helsinki U.) ; Köster, Ulli (Laue-Langevin Inst.) ; Mizohata, Kenichiro (Helsinki U.) et al.
Introduction: Porous silicon (PSi) nanoparticles are capable of delivering therapeutic payloads providing targeted delivery and sustained release of the payloads. In this work we describe the development and proof-of-concept in vivo evaluation of thermally hydrocarbonized porous silicon (PSi) nanoparticles that are implanted with radioactive $^{155}$Tb atoms and coated with red blood cell (RBC) membrane ($^{155}$Tb-THCPSi). [...]
2020 - 9 p. - Published in : Nucl. Med. Biol. 84-85 (2020) 102-110 Fulltext: PDF;

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Porous Silicon as a Platform for Radiation Theranostics Together with a Novel RIB-Based Radiolanthanoid / Jakobsson, Ulrika (Helsinki U.) ; Mäkilä, Ermei (Turku U.) ; Airaksinen, Anu J (Helsinki U.) ; Alanen, Osku (Helsinki U.) ; Etilé, Asenath (Helsinki U.) ; Köster, Ulli (Laue-Langevin Inst.) ; Ranjan, Sanjeev (Helsinki U.) ; Salonen, Jarno (Turku U.) ; Santos, Hélder A (Helsinki U.) ; Helariutta, Kerttuli (Helsinki U.)
Mesoporous silicon (PSi) is biocompatible and tailorable material with high potential in drug delivery applications. Here, we report of an evaluation of PSi as a carrier platform for theranostics by delivering a radioactive ion beam- (RIB-) based radioactive lanthanoid into tumors in a mouse model of prostate carcinoma. [...]
2019 - 10 p. - Published in : Contrast Media & Molecular Imaging 2019 (2019) 1-9 Fulltext: PDF;

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