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Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements
/ Rieker, Vilde F (CERN ; Oslo U.) ; Corsini, Roberto (CERN) ; Stapnes, Steinar (CERN) ; Adli, Erik (Oslo U.) ; Farabolini, Wilfrid (CERN) ; Grilj, Veljko (SUBATECH, Nantes) ; Sjobak, Kyrre N (Oslo U.) ; Wroe, Laurence M (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Robertson, Cameron S (Oxford U.) et al.
The discovery of the FLASH effect has revealed a high potential for treating cancer more efficiently by sparing
healthy tissue. The surge in related medical research activities over the last couple of years has triggered a
demand for technology with the capability of generating and measuring ionizing radiation at ultra-high doserates (UHDR). [...]
2024 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 1069 (2024) 169845
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Bubble-beam accelerators: breaking the paradigm
/ Malyzhenkov, Alexander (CERN) ; Latina, Andrea (CERN) ; Dyks, Luke (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Korysko, Pierre (JAI, UK ; CERN) ; Burrows, Philip (JAI, UK) ; Tranchedone, Lorenzo (JAI, UK ; CERN)
Most particle accelerators utilize beams with a charge density concentrated in the center of the bunch in real 3-dimensional space and the 6-dimensional phase space. In this work, by enhancing the space-charge forces in the photo-cathode injector of the Compact Linear Electron Accelerator for Research (CLEAR) at CERN, we produce electron bunches with a “bubble-like” shape, with a charge density mostly concentrated on the outside shell. [...]
2024 - 4 p.
- Published in : JACoW IPAC 2024 (2024) WEPC03
Fulltext: PDF;
In : 15th International Particle Accelerator Conference (IPAC 2024), Nashville, TN, United States, 19 - 24 May 2024, pp.WEPC03
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Application of beam-based alignment to the CLEAR facility
/ Aksoy, Avni (Ankara U. ; CERN) ; Malyzhenkov, Alexander (CERN) ; Latina, Andrea (CERN) ; Korysko, Pierre (Oxford U. ; CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN)
The CERN Linear Electron Accelerator for Research (CLEAR) has been operating since 2017 as a user facility providing beams for a large variety of experiments. Its RF photocathode-based linear accelerator can accelerate electrons up to 220 MeV with a bunch charge of 0.1-1.5nC with single or up to 150 bunches per train. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) WEPL025
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.WEPL025
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Real-time Plastic Scintillation Dosimetry of Ultra-High Dose Rate Very High Energy Electrons (VHEE) at CERN CLEAR Facility
/ Giguère, Cloé (Laval U.) ; Hart, Alexander (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfrid (CERN) ; LeChasseur, Yoan (McGill U.) ; Bazalova-Carter, Magdalena (Victoria U.) ; Beaulieu, Luc (Laval U.)
Very High Energy Electrons (VHEE) that can theoretically treat deep-seated tumours and be delivered at ultra-high dose rates (UHDR) could be the solution to translate FLASH radiotherapy into the clinic. Standard dosimeters have limited application in those extreme conditions, but dose-rate independent and fast-response plastic scintillation detectors (PSDs) are a potential alternative to overcome this. [...]
2024 - 4 p.
- Published in : J. Phys. : Conf. Ser. 2799 (2024) 012016
Fulltext: PDF;
In : 13th International Conference on 3D dosimetry (IC3DDose 2024), Aarhus, Denmark, 17 - 19 Jun 2024, pp.012016
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VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint
/ Wanstall, Hannah C (Manchester U. ; Daresbury) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfred (CERN) ; Corsini, Roberto (CERN) ; Bateman, Joseph J (Oxford U., Theor. Phys.) ; Rieker, Vilde (CERN ; Oslo U.) ; Hemming, Abigail (U. Manchester (main)) ; Henthorn, Nicholas T (U. Manchester (main) ; Manchester U.) ; Merchant, Michael J (Manchester U.) ; Santina, Elham (Manchester U.) et al.
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons, however, very little data is available for the effect of FLASH with Very High Energy Electrons (VHEE). [...]
2024 - 13 p.
- Published in : Sci. Rep. 14 (2024) 14803
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CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications
/ Whitmore, L (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech. ; Texas U., Houston) ; Mackay, R I (Manchester U.) ; van Herk, M (Manchester U.) ; Korysko, P (Oxford U. ; CERN) ; Farabolini, W (CERN) ; Malyzhenkov, A (CERN) ; Corsini, R (CERN) ; Jones, R M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. [...]
2024 - 15 p.
- Published in : Sci. Rep. 14 (2024) 11120
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Plastic Scintillator Dosimetry of Ultrahigh Dose-Rate 200 MeV Electrons at CLEAR
/ Hart, Alexander (Victoria U.) ; Giguère, Cloé (Laval U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Esplen, Nolan (Victoria U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (Oxford U.) ; Beaulieu, Luc (Laval U.) et al.
Very-high-energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favorable dose distributions and accessibility of ultrahigh dose rates (UHDRs). Combining VHEE with the normal tissue-sparing FLASH effect of UHDR radiotherapy could improve patient outcomes. [...]
2024 - 9 p.
- Published in : IEEE Sensors J. 24 (2024) 14229-14237
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Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates
/ Bateman, Joseph J (JAI, UK) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Korysko, Pierre (JAI, UK ; CERN) ; Larsen, Robert Garbrecht (CERN ; Groningen U.) ; Malyzhenkov, Alexander (CERN) ; Ruiz, Iñaki Ortega (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Gerbershagen, Alexander (Groningen U.)
Objective. Very high energy electrons (VHEE) in the range of 50–250 MeV are of interest for treating deep-seated tumours with FLASH radiotherapy (RT). [...]
2024 - 16 p.
- Published in : Phys. Med. Biol. 69 (2024) 085006
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Mini-GRID radiotherapy on the CLEAR very-high-energy electron beamline: collimator optimization, film dosimetry, and Monte Carlo simulations
/ Clements, Nathan (Victoria U.) ; Esplen, Nolan (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Robertson, Cameron (Oxford U.) ; Dosanjh, Manjit (Oxford U. ; CERN) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfrid (CERN) ; Corsini, Roberto (CERN) ; Bazalova-Carter, Magdalena (Victoria U.)
Objective. Spatially-fractionated radiotherapy (SFRT) delivered with a very-high-energy electron (VHEE) beam and a mini-GRID collimator was investigated to achieve synergistic normal tissue-sparing through spatial fractionation and the FLASH effect. [...]
2024 - 17 p.
- Published in : Phys. Med. Biol. 69 (2024) 055003
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