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1.
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Characterization of monolithic CMOS pixel sensor chip with ion beams for application in particle computed tomography
/ Tambave, G (Bergen U.) ; Alme, J (Bergen U.) ; Barnaföldi, G G (Wigner RCP, Budapest) ; Barthel, R (Utrecht U.) ; van den Brink, A (Utrecht U.) ; Brons, S (HITS, Heidelberg) ; Chaar, M (Bergen U.) ; Eikeland, V (Bergen U.) ; Genov, G (Bergen U.) ; Grøttvik, O (Bergen U.) et al.
Particle computed tomography (pCT) is an emerging imaging modality that promises to reduce range uncertainty in particle therapy. The Bergen pCT collaboration aims to develop a novel pCT prototype based on the ALPIDE monolithic CMOS sensor. [...]
2020 - 4 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 958 (2020) 162626
In : 15th Vienna Conference on Instrumentation, Vienna, Austria, 18 - 22 Feb 2019, pp.162626
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2.
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Measurement of $^4$He charge- and mass-changing cross sections on H, C, O, and Si targets in the energy range 70–220 MeV/u for radiation transport calculations in ion-beam therapy
/ Horst, Felix (Giessen U. ; Darmstadt, GSI) ; Aricò, Giulia (CERN) ; Brinkmann, Kai-Thomas (U. Giessen, II. Phys. Inst.) ; Brons, Stephan (Heidelberg U.) ; Ferrari, Alfredo (CERN) ; Haberer, Thomas (Heidelberg U.) ; Mairani, Andrea (Heidelberg U. ; CNAO, Pavia) ; Parodi, Katia (Munich U.) ; Reidel, Claire-Anne (Darmstadt, GSI ; Strasbourg, IPHC) ; Weber, Uli (Darmstadt, GSI) et al.
Measured charge- and mass-changing cross sections for the systems He4+C12, He4+O16, He4+Si28, and He4+H1 in the energy range 70–220MeV/u are presented. The cross sections were obtained via the attenuation method where a ΔE-E scintillator telescope was used for particle identification. [...]
2019 - 11 p.
- Published in : Phys. Rev. C 99 (2019) 014603
Fulltext from publisher: PDF;
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3.
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A measurement of $\Lambda$ polarization in inclusive production by $\Sigma^-$ of 340-GeV/c in C and Cu targets
/ Adamovich, M I (LPI, Moscow (main)) ; Alexandrov, Yu A (LPI, Moscow (main)) ; Baranov, S P (LPI, Moscow (main)) ; Barberis, D (Genoa U. ; INFN, Genoa) ; Beck, M (Heidelberg, Max Planck Inst.) ; ́erat, C B (Grenoble, CEN) ; Beusch, W (CERN) ; Boss, M (Heidelberg U.) ; Brons, S (Heidelberg, Max Planck Inst.) ; Brückner, W (Heidelberg, Max Planck Inst.) et al.
/WA89
We have measured the polarization of $\Lambda$ hyperons produced inclusively by a $\Sigma^-$ beam of 340 GeV/c momentum in nuclear targets. From a sample of 9.5 millions of identified $\Lambda$ decays, polarizations were determined in the range $x_F \gt 0.1$ and $p_t\leq 1.6$ GeV/c . [...]
2003 - 8 p.
- Published in : Eur. Phys. J. C 32 (2004) 221-228
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4.
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Dosimetric verification in water of a Monte Carlo treatment planning tool for proton, helium, carbon and oxygen ion beams at the Heidelberg Ion Beam Therapy Center
/ Tessonnier, T (Heidelberg U. Hospital ; LMU Munich (main)) ; Böhlen, TT ; Ceruti, F (CERN) ; Ferrari, A (CERN) ; Sala, P (CERN ; INFN, Milan) ; Brons, S (HITS, Heidelberg) ; Haberer, T (HITS, Heidelberg) ; Debus, J (Heidelberg U. Hospital ; HITS, Heidelberg) ; Parodi, K (Heidelberg U. Hospital ; LMU Munich (main)) ; Mairani, A (HITS, Heidelberg)
The introduction of 'new' ion species in particle therapy needs to be supported by a thorough assessment of their dosimetric properties and by treatment planning comparisons with clinically used proton and carbon ion beams. In addition to the latter two ions, helium and oxygen ion beams are foreseen at the Heidelberg Ion Beam Therapy Center (HIT) as potential assets for improving clinical outcomes in the near future. [...]
2017 - 16 p.
- Published in : Phys. Med. Biol. 62 (2017) 6579-6594
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5.
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Helium ions at the heidelberg ion beam therapy center: comparisons between FLUKA Monte Carlo code predictions and dosimetric measurements
/ Tessonnier, T (Heidelberg U. Hospital ; LMU Munich (main)) ; Mairani, A (HITS, Heidelberg) ; Brons, S (HITS, Heidelberg) ; Sala, P (CERN ; INFN, Milan) ; Cerutti, F (CERN) ; Ferrari, A (CERN) ; Haberer, T (HITS, Heidelberg) ; Debus, J (Heidelberg U. Hospital ; HITS, Heidelberg) ; Parodi, K (Heidelberg U. Hospital ; LMU Munich (main))
In the field of particle therapy helium ion beams could offer an alternative for radiotherapy treatments, owing to their interesting physical and biological properties intermediate between protons and carbon ions. We present in this work the comparisons and validations of the Monte Carlo FLUKA code against in-depth dosimetric measurements acquired at the Heidelberg Ion Beam Therapy Center (HIT). [...]
2017 - 20 p.
- Published in : Phys. Med. Biol. 62 (2017) 6784-6803
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6.
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Characterization of equipment for shaping and imaging hadron minibeams
/ Pugatch, V (Kiev, INR) ; Brons, S (Heidelberg U. Hospital) ; Campbell, M (CERN) ; Kovalchuk, O (Kiev, INR) ; Llopart, X (CERN) ; Martínez-Rovira, I (IMNC, Orsay) ; Momot, Ie (Goethe U., Frankfurt (main) ; Kiev, INR) ; Okhrimenko, O (Kiev, INR) ; Prezado, Y (IMNC, Orsay) ; Sorokin, Yu (Mainz U. ; Kiev, INR)
For the feasibility studies of spatially fractionated hadron therapy prototypes of the equipment for hadron minibeams shaping and monitoring have been designed, built and tested. The collimators design was based on Monte Carlo simulations (Gate v.6.2). [...]
2017 - 7 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 872 (2017) 119-125
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7.
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Investigating the robustness of ion beam therapy treatment plans to uncertainties in biological treatment parameters
/ Boehlen, T T (CERN ; Stockholm U. ; Karolinska Inst., Stockholm) ; Brons, S (Ion Beam Therapy Ctr, Heidelberg) ; Dosanjh, M (CERN) ; Ferrari, A (CERN) ; Fossati, P (CNAO, Pavia, Italy. ; U. Milan ; Eur. Inst. Oncol., Milan) ; Haberer, T (Ion Beam Therapy Ctr, Heidelberg) ; Mairani, A (Fdn CNAO, Pavia) ; Patera, V (U. Rome La Sapienza (main) ; Frascati)
Uncertainties in determining clinically used relative biological effectiveness (RBE) values for ion beam therapy carry the risk of absolute and relative misestimations of RBE-weighted doses for clinical scenarios. This study assesses the consequences of hypothetical misestimations of input parameters to the RBE modelling for carbon ion treatment plans by a variational approach. [...]
2012
- Published in : Phys. Med. Biol. 57 (2012) 7983-8004
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8.
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The FLUKA Monte Carlo code coupled with the local effect model for biological calculations in carbon ion therapy
/ Mairani, A (INFN, Milan ; Pavia U. ; INFN, Pavia ; Ion Beam Therapy Ctr, Heidelberg ; Dept Radiat Oncol, Heidelberg) ; Brons, S (Ion Beam Therapy Ctr, Heidelberg ; Dept Radiat Oncol, Heidelberg) ; Kraemer, M (Darmstadt, GSI) ; Sommerer, F (CERN) ; Parodi, K (Ion Beam Therapy Ctr, Heidelberg ; Dept Radiat Oncol, Heidelberg) ; Scholz, M (Darmstadt, GSI) ; Cerutti, F (CERN) ; Ferrari, A (CERN) ; Fasso, A (SLAC)
Clinical Monte Carlo (MC) calculations for carbon ion therapy have to provide absorbed and RBE-weighted dose. The latter is defined as the product of the dose and the relative biological effectiveness (RBE). [...]
2010
- Published in : Phys. Med. Biol. 55 (2010) 4273-4289
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9.
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The influence of lateral beam profile modifications in scanned proton and carbon ion therapy: a Monte Carlo study
/ Parodi, K (Univ Clin Heidelberg, Heidelberg Ion Beam Therapy Ctr HIT, Neuenheimer Feld 450, D-69120 Heidelberg, Germany. ; Univ Clin Heidelberg, Heidelberg Ion Beam Therapy Ctr HIT, D-69120 Heidelberg, Germany. ; Univ Clin Heidelberg, Dept Radiat Oncol, D-69120 Heidelberg, Germany.) ; Haberer, T (Univ Clin Heidelberg, Heidelberg Ion Beam Therapy Ctr HIT, D-69120 Heidelberg, Germany. ; Univ Clin Heidelberg, Dept Radiat Oncol, D-69120 Heidelberg, Germany.) ; Kraemer, M (GSI Helmholtzzentrum Schwerionenforsch, Dept Biophys, D-64291 Darmstadt, Germany.) ; Sommerer, F (Univ Clin Heidelberg, Heidelberg Ion Beam Therapy Ctr HIT, D-69120 Heidelberg, Germany. ; Univ Clin Heidelberg, Dept Radiat Oncol, D-69120 Heidelberg, Germany. ; CERN) ; Naumann, J (Univ Clin Heidelberg, Heidelberg Ion Beam Therapy Ctr HIT, D-69120 Heidelberg, Germany. ; Univ Clin Heidelberg, Dept Radiat Oncol, D-69120 Heidelberg, Germany.) ; Mairani, A (Univ Clin Heidelberg, Heidelberg Ion Beam Therapy Ctr HIT, D-69120 Heidelberg, Germany. ; Univ Clin Heidelberg, Dept Radiat Oncol, D-69120 Heidelberg, Germany.) ; Brons, S (Univ Clin Heidelberg, Heidelberg Ion Beam Therapy Ctr HIT, D-69120 Heidelberg, Germany. ; Univ Clin Heidelberg, Dept Radiat Oncol, D-69120 Heidelberg, Germany.)
Scanned ion beam delivery promises superior flexibility and accuracy for highly conformal tumour therapy in comparison to the usage of passive beam shaping systems. The attainable precision demands correct overlapping of the pencil-like beams which build up the entire dose distribution in the treatment field. [...]
2010
- Published in : Phys. Med. Biol. 55 (2010) 5169-5187
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10.
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The role of nuclear reactions in Monte Carlo calculations of absorbed and biological effective dose distributions in hadron therapy
/ Brons, S (Heidelberg Ion Therapy Center) ; Cerutti, F (CERN) ; Elsässer, T (Darmstadt, GSI) ; Ferrari, A (CERN) ; Gadioli, E (INFN, Milan ; Milan U.) ; Mairani, A (Heidelberg Ion Therapy Center ; INFN) ; Parodi, K (Heidelberg Ion Therapy Center) ; Sala, P (INFN) ; Scholz, M (Darmstadt, GSI) ; Sommerer, F (Heidelberg Ion Therapy Center)
Monte Carlo codes are rapidly spreading among hadron therapy community due to their sophisticated nuclear/electromagnetic models which allow an improved description of the complex mixed radiation field produced by nuclear reactions in therapeutic irradiation. In this contribution results obtained with the Monte Carlo code FLUKA are presented focusing on the production of secondary fragments in carbon ion interaction with water and on CT-based calculations of absorbed and biological effective dose for typical clinical situations. [...]
2010
Published version from CERN: PDF;
In : 12th International Conference on Nuclear Reaction Mechanisms, Villa Monastero, Varenna, Italy, 15 - 19 Jun 2009, pp.517-525
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