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1.
CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications / Whitmore, L (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech. ; Texas U., Houston) ; Mackay, R I (Manchester U.) ; van Herk, M (Manchester U.) ; Korysko, P (Oxford U. ; CERN) ; Farabolini, W (CERN) ; Malyzhenkov, A (CERN) ; Corsini, R (CERN) ; Jones, R M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. [...]
2024 - 15 p. - Published in : Sci. Rep. 14 (2024) 11120 Fulltext: PDF;
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2.
Influence of heterogeneous media on Very High Energy Electron (VHEE) dose penetration and a Monte Carlo-based comparison with existing radiotherapy modalities / Lagzda, Agnese (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.) ; Angal-Kalinin, Deepa (Cockcroft Inst. Accel. Sci. Tech. ; Daresbury) ; Jones, James (Cockcroft Inst. Accel. Sci. Tech. ; Daresbury) ; Aitkenhead, Adam (Unlisted, UK ; Manchester U.) ; Kirkby, Karen J (Unlisted, UK ; Manchester U.) ; MacKay, Ranald (Unlisted, UK ; Manchester U.) ; Van Herk, Marcel (Unlisted, UK ; Manchester U.) ; Farabolini, Wilfrid (CERN) ; Zeeshan, Sumaira (CERN) ; Jones, Roger M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
• First experimental demonstration of the relative insensitivity of VHEE beams to inhomogeneities. • Topas/GEANT4 simulations on experiments conducted at CERN’s CLEAR facility are in good agreement. [...]
2020 - 12 p. - Published in : Nucl. Instrum. Methods Phys. Res., B 482 (2020) 70-81
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3.
Very-High Energy Electron (VHEE) Studies at CERN's CLEAR User Facility / Lagzda, Agnese (U. Manchester (main) ; Cockcroft Inst. Accel. Sci. Tech.) ; Aitkenhead, Adam (Manchester U.) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Jones, Roger (U. Manchester (main) ; Cockcroft Inst. Accel. Sci. Tech.) ; Kirkby, Karen (U. Manchester (main) ; Cockcroft Inst. Accel. Sci. Tech. ; Manchester U.) ; MacKay, Ranald (Manchester U. ; U. Manchester (main)) ; Van Herk, Marcel (Manchester U.)
Here we investigate how inserts of various densities (0.001-2.2 g/cm³) affect the dose distribution properties of VHEE beams at ~150 MeV. A range variation comparison was also made with clinical proton beams using TOPAS/GEANT4 Monte Carlo simulations. [...]
2018 - 4 p. - Published in : 10.18429/JACoW-IPAC2018-MOPML023 Fulltext: PDF;
In : 9th International Particle Accelerator Conference, Vancouver, Canada, 29 Apr - 4 May 2018, pp.MOPML023
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