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Quantitative imaging of excised osteoarthritic cartilage using spectral CT / Rajendran, Kishore (Otago U.) ; Löbker, Caroline (Otago U.) ; Schon, Benjamin S (Twente U., Enschede) ; Bateman, Christopher J (Otago U.) ; Younis, Raja Aamir (Otago U.) ; de Ruiter, Niels J A (Otago U.) ; Chernoglazov, Alex I (Canterbury U.) ; Ramyar, Mohsen (Otago U.) ; Hooper, Gary J (Otago U.) ; Butler, Anthony P H (Otago U. ; CERN ; MARS Bioimaging, New Zealand) et al.
Objectives: To quantify iodine uptake in articular cartilage as a marker of glycosaminoglycan (GAG) content using multi-energy spectral CT. Methods: We incubated a 25-mm strip of excised osteoarthritic human tibial plateau in 50 % ionic iodine contrast and imaged it using a small-animal spectral scanner with a cadmium telluride photon-processing detector to quantify the iodine through the thickness of the articular cartilage. We imaged both spectroscopic phantoms and osteoarthritic tibial plateau samples. [...]
2017 - 9 p. - Published in : Eur. Radiol. 27 (2017) 384-392

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