|
1.
|
FLUKA particle therapy tool for Monte Carlo independent calculation of scanned proton and carbon ion beam therapy
/ Kozłowska, Wioletta Sandra (CERN ; Med. U. of Vienna, Spitalgasse) ; Böhlen, Till Tobias (PSI, Villigen) ; Cuccagna, Caterina (TERA Foundation, Geneva ; U. Geneva (main)) ; Ferrari, Alfredo (CERN) ; Fracchiolla, Francesco (Proton Therapy Center, Trento) ; Georg, Dietmar (Med. U. of Vienna, Spitalgasse ; Christian Doppler Lab., Vienna) ; Magro, Giuseppe (CNAO, Pavia) ; Mairani, Andrea (CNAO, Pavia ; Heidelberg Ion-Beam Therapy Center) ; Schwarz, Marco (Proton Therapy Center, Trento ; TIFPA-INFN, Trento) ; Vlachoudis, Vasilis (CERN)
While Monte Carlo (MC) codes are considered as the gold standard for dosimetric calculations, the availability of user friendly MC codes suited for particle therapy is limited. Based on the FLUKA MC code and its graphical user interface (GUI) Flair, we developed an easy-to-use tool which enables simple and reliable simulations for particle therapy. [...]
2019 - 12 p.
- Published in : Phys. Med. Biol. 64 (2019) 075012
Fulltext: PDF;
|
|
|
2.
|
Optimizing the modified microdosimetric kinetic model input parameters for proton and $^4$He ion beam therapy application
/ Mairani, A (CNAO, Milan ; Heidelberg Ion Beam Therapy Center, Heidelberg) ; Magro, G (CNAO, Milan) ; Tessonnier, T (Heidelberg U. Hospital ; LMU Munich (main)) ; Böhlen, T T (EBG MedAustron GmbH, Wiener Neustadt) ; Molinelli, S (CNAO, Milan) ; Ferrari, A (CERN) ; Parodi, K (Heidelberg Ion Beam Therapy Center, Heidelberg ; Heidelberg U. Hospital ; LMU Munich (main)) ; Debus, J (Heidelberg Ion Beam Therapy Center, Heidelberg ; Heidelberg U. Hospital) ; Haberer, T (Heidelberg Ion Beam Therapy Center, Heidelberg)
Models able to predict relative biological effectiveness (RBE) values are necessary for an accurate determination of the biological effect with proton and $^4$He ion beams. This is particularly important when including RBE calculations in treatment planning studies comparing biologically optimized proton and $^4$He ion beam plans. [...]
2017 - 13 p.
- Published in : Phys. Med. Biol. 62 (2017) N244-N256
|
|
|
3.
|
Dosimetric verification in water of a Monte Carlo treatment planning tool for proton, helium, carbon and oxygen ion beams at the Heidelberg Ion Beam Therapy Center
/ Tessonnier, T (Heidelberg U. Hospital ; LMU Munich (main)) ; Böhlen, TT ; Ceruti, F (CERN) ; Ferrari, A (CERN) ; Sala, P (CERN ; INFN, Milan) ; Brons, S (HITS, Heidelberg) ; Haberer, T (HITS, Heidelberg) ; Debus, J (Heidelberg U. Hospital ; HITS, Heidelberg) ; Parodi, K (Heidelberg U. Hospital ; LMU Munich (main)) ; Mairani, A (HITS, Heidelberg)
The introduction of 'new' ion species in particle therapy needs to be supported by a thorough assessment of their dosimetric properties and by treatment planning comparisons with clinically used proton and carbon ion beams. In addition to the latter two ions, helium and oxygen ion beams are foreseen at the Heidelberg Ion Beam Therapy Center (HIT) as potential assets for improving clinical outcomes in the near future. [...]
2017 - 16 p.
- Published in : Phys. Med. Biol. 62 (2017) 6579-6594
|
|
|
4.
|
A phenomenological relative biological effectiveness approach for proton therapy based on an improved description of the mixed radiation field
/ Mairani, A (CNAO Foundation, Pavia ; HIT, Heidelberg) ; Dokic, I (HIT, Heidelberg ; Heidelberg, Inst. Radiology) ; Magro, G (CNAO Foundation, Pavia) ; Tessonnier, T (Munich U. ; Heidelberg, Inst. Radiology) ; Bauer, J (HIT, Heidelberg ; Heidelberg, Inst. Radiology) ; Böhlen, TT (EBG GmbH MedAustron, Austria) ; Ciocca, M (CNAO Foundation, Pavia) ; Ferrari, A (CERN) ; Sala, P R (INFN, Milan) ; Jäkel, O (HIT, Heidelberg ; Heidelberg, Inst. Radiology) et al.
Proton therapy treatment planning systems (TPSs) are based on the assumption of a constant relative biological effectiveness (RBE) of 1.1 without taking into account the found in vitro experimental variations of the RBE as a function of tissue type, linear energy transfer (LET) and dose. The phenomenological RBE models available in literature are based on the dose-averaged LET (LET D ) as an indicator of the physical properties of the proton radiation field. [...]
2017 - 18 p.
- Published in : Phys. Med. Biol. 62 (2017) 1378-1395
|
|
|
5.
|
Biologically optimized helium ion plans: calculation approach and its in vitro validation
/ Mairani, A (CNAO, Milan ; HITS, Heidelberg) ; Dokic, I (HITS, Heidelberg ; Heidelberg, Inst. Radiology ; Heidelberg U. Hospital) ; Magro, G (CNAO, Milan) ; Tessonnier, T (Heidelberg U. Hospital ; Munich U., Neutron Group) ; Kamp, F (Munich U.) ; Carlson, D J (Yale U. (main)) ; Ciocca, M (CNAO, Milan) ; Cerutti, F (CERN) ; Sala, P R (INFN, Milan ; Yale U.) ; Ferrari, A (CERN) et al.
Treatment planning studies on the biological effect of raster-scanned helium ion beams should be performed, together with their experimental verification, before their clinical application at the Heidelberg Ion Beam Therapy Center (HIT). For this purpose, we introduce a novel calculation approach based on integrating data-driven biological models in our Monte Carlo treatment planning (MCTP) tool. [...]
2016 - 17 p.
- Published in : Phys. Med. Biol. 61 (2016) 4283-4299
|
|
|
6.
|
Variable RBE in proton therapy: comparison of different model predictions and their influence on clinical-like scenarios
/ Giovannini, Giulia (Munich U. ; Pavia U. ; Heidelberg, Inst. Radiology) ; Böhlen, Till (CERN ; Munich U. ; Fachhochsch., Wiener Neustadt) ; Cabal, Gonzalo (Munich U.) ; Bauer, Julia (Heidelberg Ion-Beam Therapy Center (HIT) ; Heidelberg, Inst. Radiology) ; Tessonnier, Thomas (Heidelberg, Inst. Radiology) ; Frey, Kathrin (Munich U.) ; Debus, Jürgen (Heidelberg, Inst. Radiology ; Heidelberg Ion-Beam Therapy Center (HIT)) ; Mairani, Andrea (CNAO Foundation, Pavia ; Heidelberg Ion-Beam Therapy Center (HIT)) ; Parodi, Katia (Munich U. ; Heidelberg, Inst. Radiology ; Heidelberg Ion-Beam Therapy Center (HIT))
Background: In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, biological experiments have evidenced RBE dependencies on dose level, proton linear energy transfer (LET) and tissue type. [...]
2016 - 16 p.
- Published in : Radiat. Oncol. 11 (2016) 68
Fulltext: PDF;
|
|
|
7.
|
Data-driven RBE parameterization for helium ion beams
/ Mairani, A (CNAO, Milan ; HITS, Heidelberg) ; Magro, G (CNAO, Milan ; Pavia U. ; INFN, Pavia) ; Dokic, I (HITS, Heidelberg ; Heidelberg, Inst. Radiology ; Heidelberg U.) ; Valle, S M (Pavia U.) ; Tessonnier, T (Munich U., Inst. Astron. Astrophys. ; Heidelberg U.) ; Galm, R (HITS, Heidelberg ; Heidelberg, Inst. Radiology ; Heidelberg U.) ; Ciocca, M (CNAO, Milan) ; Parodi, K (HITS, Heidelberg ; Heidelberg U. ; Munich U., Inst. Astron. Astrophys.) ; Ferrari, A (CERN) ; Jäkel, O (HITS, Heidelberg ; Heidelberg, Inst. Radiology) et al.
Helium ion beams are expected to be available again in the near future for clinical use. A suitable formalism to obtain relative biological effectiveness (RBE) values for treatment planning (TP) studies is needed. [...]
2016 - 18 p.
- Published in : Phys. Med. Biol. 61 (2016) 888-905
|
|
|
8.
|
The FLUKA code: An accurate simulation tool for particle therapy
/ Battistoni, Giuseppe (INFN, Milan) ; Bauer, Julia (Uniklinikum, Heidelberg) ; Böhlen, Till T (Uniklinikum, Heidelberg) ; Cerutti, Francesco (CERN) ; Chin, Mary Pik Wai (CERN) ; Dos Santos Augusto, Ricardo M (LMU Munich (main) ; CERN) ; Ferrari, Alfredo (CERN) ; Garcia Ortega, Pablo (CERN) ; Kozlowska, Wioletta S (HIT, Heidelberg ; CERN) ; Magro, Giuseppe (CNAO, Milan) et al.
Monte Carlo (MC) codes are increasingly spreading in the hadrontherapy community due to their detailed description of radiation transport and interaction with matter. The suitability of a MC code for application to hadrontherapy demands accurate and reliable physical models capable of handling all components of the expected radiation field. [...]
2016
- Published in : Front. Oncol. 6 (2016) 116
Frontiers Open Access article: PDF;
|
|
|
9.
|
|
|
10.
|
The FLUKA Code: Developments and Challenges for High Energy and Medical Applications
/ Böhlen, T T (CERN) ; Cerutti, F (CERN) ; Chin, M P W (CERN) ; Fassò, A ; Ferrari, A (CERN) ; Ortega, P G (CERN) ; Mairani, A ; Sala, P R (INFN, Milan) ; Smirnov, G (CERN) ; Vlachoudis, V (CERN)
The FLUKA Monte Carlo code is used extensively at CERN for all beam-machine interactions, radioprotection calculations and facility design of forthcoming projects. Such needs require the code to be consistently reliable over the entire energy range (from MeV to TeV) for all projectiles (full suite of elementary particles and heavy ions). [...]
2014 - 4 p.
- Published in : Nucl. Data Sheets 120 (2014) 211-214
|
|
email alert
ή εγγραφείτε στο 
RSS feed.