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1.
Novel radionuclides for use in Nuclear Medicine in Europe: where do we stand and where do we go? / Radzina, Maija (Latvia U. ; CERN) ; Saule, Laura (Latvia U.) ; Mamis, Edgars (Latvia U. ; CERN) ; Koester, Ulli (Laue-Langevin Inst.) ; Cocolios, Thomas Elias (Leuven U.) ; Pajuste, Elina (Latvia U.) ; Kalnina, Marika (Unlisted) ; Palskis, Kristaps (CERN ; Riga Tech. U.) ; Sawitzki, Zoe (Leuven U.) ; Talip, Zeynep (PSI, Villigen) et al.
Background In order to support the ongoing research across Europe to facilitate access to novel radionuclides, the PRISMAP consortium (European medical radionuclides programme) was established to offer the broadest catalog of non-conventional radionuclides for medical and translational research. The aim of this article is to introduce readers with current status of novel radionuclides in Europe. Main body A consortium questionnaire was disseminated through the PRISMAP consortium and user community, professional associations and preclinical/clinical end users in Europe and the current status of clinical end-users in nuclear medicine were identified. [...]
2023 - 16 p. - Published in : EJNMMI Radiopharm. Chem. 8 (2023) 27 Fulltext: PDF;
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2.
Measurement of the $^{14}$N(n,p)$^{14}$C cross section at the CERN n_TOF facility from sub-thermal energy to 800 keV / n_TOF Collaboration
Background: The $^{14}$N(n,p)$^{14}$C reaction is of interest in neutron capture therapy, where nitrogen-related dose is the main component due to low-energy neutrons, and in astrophysics, where 14N acts as a neutron poison in the s-process. Several discrepancies remain between the existing data obtained in partial energy ranges: thermal energy, keV region and resonance region. [...]
arXiv:2212.05128.- 2023-06-29 - 15 p. - Published in : Phys. Rev. C 107 (2023) 064617 Fulltext: 2212.05128 - PDF; Publication - PDF;
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3.
Efficient Production of High Specific Activity Thulium-167 at Paul Scherrer Institute and CERN-MEDICIS / Heinke, Reinhard (CERN ; Leuven U.) ; Chevallay, Eric (CERN) ; Chrysalidis, Katerina (CERN) ; Cocolios, Thomas E (Leuven U.) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Fedosseev, Valentin N (CERN) ; Hurier, Sophie (Leuven U. ; SCK-CEN, Mol) ; Lambert, Laura (CERN) ; Leenders, Benji (Leuven U. ; SCK-CEN, Mol ; Gent U.) ; Marsh, Bruce A (CERN) et al.
Thulium-167 is a promising radionuclide for nuclear medicine applications with potential use for both diagnosis and therapy (“theragnostics”) in disseminated tumor cells and small metastases, due to suitable gamma-line as well as conversion/Auger electron energies. However, adequate delivery methods are yet to be developed and accompanying radiobiological effects to be investigated, demanding the availability of $^{167}$Tm in appropriate activities and quality. [...]
2021 - Published in : Frontiers in Medicine 8 (2021) 712374 Fulltext: PDF;
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4.
CERN-MEDICIS: A Review Since Commissioning in 2017 / MEDICIS Collaboration
The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. [...]
2021 - 11 p. - Published in : Frontiers in Medicine 8 (2021) 693682 Fulltext: PDF;
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5.
Production of Mass-Separated Erbium-169 Towards the First Preclinical in vitro Investigations / Talip, Zeynep (PSI, Villigen) ; Borgna, Francesca (PSI, Villigen) ; Müller, Cristina (PSI, Villigen ; ETH, Zurich (main)) ; Ulrich, Jiri (PSI, Villigen) ; Duchemin, Charlotte (CERN ; Leuven U.) ; Ramos, Joao P (CERN ; Leuven U.) ; Stora, Thierry (CERN) ; Köster, Ulli (Laue-Langevin Inst.) ; Nedjadi, Youcef (Lausanne U.) ; Gadelshin, Vadim (CERN ; Mainz U., Inst. Phys. ; Urals State U.) et al.
The $\beta^-$-particle-emitting erbium-169 is a potential radionuclide toward therapy of metastasized cancer diseases. It can be produced in nuclear research reactors, irradiating isotopically-enriched $^{168}$Er$_2$O$_3$ [...]
2021 - 11 p. - Published in : Frontiers in Medicine 8 (2021) 643175 Fulltext: PDF;
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6.
CERN-MEDICIS: A Unique Facility for the Production of Non-Conventional Radionuclides for the Medical Research / Duchemin, Charlotte (CERN) ; Barbero-Soto, Esther (CERN) ; Bernardes, Ana (CERN) ; Catherall, Richard (CERN) ; Chevallay, Eric (CERN) ; Cocolios, Thomas (Leuven U.) ; Dorsival, Alexandre (CERN) ; Fedosseev, Valentin (CERN) ; Fernier, Pascal (CERN) ; Gilardoni, Simone (CERN) et al.
The MEDICIS facility is a unique facility located at CERN dedicated to the production of non-conventional radionuclides for research and development in imaging, diagnostics and radiation therapy. It exploits in a Class A work sector, a dedicated isotope separator beam line, a target irradiation station at the 1.4 GeV Proton Synchroton Booster (PSB) and receives activated targets from external institutes during CERN Long Shut-Downs. [...]
CERN-ACC-2021-010.- 2021 - 5 p. - Published in : JACoW IPAC 2020 (2020) THVIR13 Fulltext: PDF;
In : 11th International Particle Accelerator Conference, Caen, France, 10 - 15 May 2020, pp.THVIR13
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7.
Ytterbium-175 half-life determination / Durán, M Teresa (Inst. Appl. Radiophys., Lausanne) ; Juget, Frédéric (Inst. Appl. Radiophys., Lausanne) ; Nedjadi, Youcef (Inst. Appl. Radiophys., Lausanne) ; Bochud, François (Inst. Appl. Radiophys., Lausanne) ; Talip, Zeynep (PSI, Villigen) ; van der Meulen, Nicholas P (PSI, Villigen) ; Köster, Ulli (Laue-Langevin Inst.) ; Duchemin, Charlotte (CERN ; Leuven U.) ; Stora, Thierry (CERN) ; Bailat, Claude (Inst. Appl. Radiophys., Lausanne)
$^{175}$Yb is a radionuclide that can be generated by neutron capture on $^{174}$Yb and whose decay properties make it useful for developing therapeutic radiopharmaceuticals. As it happens with many of the emerging radionuclides for medical uses in recent years, its nuclear data were determined decades ago and are not thoroughly documented nor accurate enough for metrological purposes. [...]
2021 - 8 p. - Published in : Appl. Radiat. Isot. 176 (2021) 109893 Fulltext from publisher: PDF;
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8.
Terbium-149 for targeted alpha therapy / Borgna, Francesca (PSI) ; Favaretto, Chiara (PSI) ; Grundler, Pascal (PSI) ; Johnston, Karl (CERN) ; Köster, Ulli (ILL) ; Müller, Cristina (PSI) ; Talip, Zeynep (PSI) ; van der Meulen, Nick (PSI)
CERN-INTC-2021-008 ; INTC-P-593. - 2021.
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