| Article | |
| Title | Determination of the Terbium-152 half-life from mass-separated samples from CERN-ISOLDE and assessment of the radionuclide purity |
| Author(s) | Collins, S M (Teddington, Natl. Phys. Lab ; U. Surrey (main)) ; Ko¨ster, U (Laue-Langevin Inst.) ; Robinson, A P (Teddington, Natl. Phys. Lab ; U. Manchester (main) ; Manchester U.) ; Ivanov, P (Teddington, Natl. Phys. Lab) ; Cocolios, T E (Leuven U.) ; Russell, B (Teddington, Natl. Phys. Lab) ; Fenwick, A J (Teddington, Natl. Phys. Lab) ; Bernerd, C (Leuven U. ; CERN) ; Stegemann, S (Leuven U.) ; Johnston, K (CERN) ; Gerami, A M (CERN) ; Chrysalidis, K (CERN) ; Mohamud, H (Teddington, Natl. Phys. Lab) ; Ramirez, N (Teddington, Natl. Phys. Lab) ; Bhaisare, A (Teddington, Natl. Phys. Lab) ; Mewburn-Crook, J (Teddington, Natl. Phys. Lab) ; Cullen, D M (Manchester U.) ; Pietras, B (Manchester U.) ; Pells, S (Manchester U.) ; Dockx, K (Leuven U.) ; Stucki, N (Dortmund U.) ; Regan, P H (Teddington, Natl. Phys. Lab ; U. Surrey (main)) |
| Publication | 2023 |
| Number of pages | 16 |
| In: | Appl. Radiat. Isot. 202 (2023) 111044 |
| DOI | 10.1016/j.apradiso.2023.111044 (publication) |
| Accelerator/Facility, Experiment | CERN ISOLDE |
| Abstract | Terbium-152 is one of four terbium radioisotopes that together form a potential theranostic toolbox for the personalised treatment of tumours. As 152 Tb decay by positron emission it can be utilised for diagnostics by positron emission tomography. For use in radiopharmaceuticals and for activity measurements by an activity calibrator a high radionuclide purity of the material and an accurate and precise knowledge of the half-life is required. Mass-separation and radiochemical purification provide a production route of high purity 152Tb. In the current work, two mass-separated samples from the CERN-ISOLDE facility have been assayed at the National Physical Laboratory to investigate the radionuclide purity. These samples have been used to perform four measurements of the half-life by three independent techniques: high-purity germanium gamma-ray spectrometry, ionisation chamber measurements and liquid scintillation counting. From the four measurement campaigns a half-life of 17.8784(95) h has been determined. The reported half-life shows a significant difference to the currently evaluated half-life (ζ-score = 3.77), with a relative difference of 2.2 % and an order of magnitude improvement in the precision. This work also shows that under controlled conditions the combination of mass-separation and radiochemical separation can provide high-purity 152Tb. •First half-life measurement of 152Tb since 1970.•Precise half-life of 152Tb determined by three independent techniques from mass-separated samples.•Presented half-life value shows a relative difference of 2.2% from current evaluated value.•Order of magnitude improvement in the precision to the current evaluated value.•Radionuclide contaminants from two mass-separated samples assessed. |
| Copyright/License | publication: © 2023-2024 The Authors (License: CC BY 4.0) |
Corresponding record in: Inspire
Записът е създаден на 2023-11-30, последна промяна на 2024-09-27
