CERN Accelerating science

Article
Report number	arXiv:1311.4528
Title	MARS spectral molecular imaging of lamb tissue: data collection and image analysis
Author(s)	Aamir, R. (Otago U.) ; Chernoglazov, A. (Canterbury U.) ; Bateman, C.J. (Otago U.) ; Butler, A.P.H. (Otago U. ; CERN ; Canterbury U.) ; Butler, P.H. (CERN ; Canterbury U.) ; Anderson, N.G. (Otago U.) ; Bell, S.T. (Unlisted, NZ) ; Panta, R.K. (Otago U.) ; Healy, J.L. (Canterbury U.) ; Mohr, J.L. (Otago U.) ; Rajendran, K. (Otago U.) ; Walsh, M.F. (Otago U.) ; Ruiter, N.de (Canterbury U.) ; Gieseg, S.P. (Canterbury U.) ; Woodfield, T. (Otago U.) ; Renaud, P.F. (Canterbury U.) ; Brooke, L. (Canterbury U.) ; Abdul-Majid, S. (Jeddah U.) ; Clyne, M. (Unlisted, NZ) ; Glendenning, R. (Unlisted, NZ) ; Bones, P.J. (Canterbury U.) ; Billinghurst, M. (Canterbury U.) ; Bartneck, C. (Canterbury U.) ; Mandalika, H. (Canterbury U.) ; Grasset, R. (Canterbury U.) ; Schleich, N. (Otago U.) ; Scott, N. (Canterbury U.) ; Nik, S.J. (Canterbury U.) ; Opie, A. (Canterbury U.) ; Janmale, T. (Canterbury U.) ; Tang, D.N. (Canterbury U.) ; Kim, D. (Canterbury U.) ; Doesburg, R.M. (CERN ; Canterbury U.) ; Zainon, R. (Canterbury U.) ; Ronaldson, J.P. (Otago U.) ; Cook, N.J. (Canterbury U.) ; Smithies, D.J. (Canterbury U.) ; Hodge, K. (Otago U.)
Publication	2014-02-17
Imprint	18 Nov 2013
Number of pages	11
Note	Comments: 11 pages, 6 figs 11 pages, 6 figs
In:	JINST 9 (2014) P02005
DOI	10.1088/1748-0221/9/02/P02005
Subject category	Health Physics and Radiation Effects
Abstract	Spectral molecular imaging is a new imaging technique able to discriminate and quantify different components of tissue simultaneously at high spatial and high energy resolution. Our MARS scanner is an x-ray based small animal CT system designed to be used in the diagnostic energy range (20 to 140 keV). In this paper, we demonstrate the use of the MARS scanner, equipped with the Medipix3RX spectroscopic photon-processing detector, to discriminate fat, calcium, and water in tissue. We present data collected from a sample of lamb meat including bone as an illustrative example of human tissue imaging. The data is analyzed using our 3D Algebraic Reconstruction Algorithm (MARS-ART) and by material decomposition based on a constrained linear least squares algorithm. The results presented here clearly show the quantification of lipid-like, water-like and bone-like components of tissue. However, it is also clear to us that better algorithms could extract more information of clinical interest from our data. Because we are one of the first to present data from multi-energy photon-processing small animal CT systems, we make the raw, partial and fully processed data available with the intention that others can analyze it using their familiar routines.
Copyright/License	publication: © 2014-2024 CERN (License: CC-BY-3.0)

Corresponding record in: Inspire