PDXK

PDXK
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2AJP, 2F7K, 2YXT, 2YXU, 3FHX, 3FHY, 3KEU, 4EN4, 4EOH
Identifikatori
Aliasi	PDXK
Vanjski ID-jevi	OMIM: 179020 MGI: 1351869 HomoloGene: 2731 GeneCards: PDXK
Lokacija gena (čovjek) Hrom. Hromosom 21 (čovjek) Bend 21q22.3 Početak 43,719,094 bp Kraj 43,762,307 bp
Lokacija gena (miš) Hrom. Hromosom 10 (miš) Bend 10 C1|10 39.72 cM Početak 78,272,578 bp Kraj 78,300,809 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • nucleotide binding • protein homodimerization activity • pyridoxal kinase activity • vezivanje iona cinka • potassium ion binding • sodium ion binding • vezivanje iona metala • kinase activity • lithium ion binding • pyridoxal phosphate binding • ATP binding • magnesium ion binding Ćelijska komponenta • citosol • Egzosom • jedro • extracellular region • citoplazma • secretory granule lumen • specific granule lumen • nukleoplazma Biološki proces • pyridoxal phosphate biosynthetic process • Fosforilacija • pyridoxal 5'-phosphate salvage • Ćelijska proliferacija • neutrophil degranulation • vitamin B6 metabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8566	216134
Ensembl	ENSG00000160209	ENSMUSG00000032788
UniProt	O00764	Q8K183
RefSeq (mRNK)	NM_003681 NM_021941 NM_001331030	NM_172134
RefSeq (bjelančevina)	NP_001317959 NP_003672	NP_742146
Lokacija (UCSC)	Chr 21: 43.72 – 43.76 Mb	Chr 10: 78.27 – 78.3 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Piridoksal-kinaza jest enzim koji je kod ljudi kodiran genom PDXK sa hromosoma 21.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 312 aminokiselina, a molekulska težina 35.102 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MEEECRVLSI		QSHVIRGYVG		NRAATFPLQV		LGFEIDAVNS		VQFSNHTGYA
HWKGQVLNSD		ELQELYEGLR		LNNMNKYDYV		LTGYTRDKSF		LAMVVDIVQE
LKQQNPRLVY		VCDPVLGDKW		DGEGSMYVPE		DLLPVYKEKV		VPLADIITPN
QFEAELLSGR		KIHSQEEALR		VMDMLHSMGP		DTVVITSSDL		PSPQGSNYLI
VLGSQRRRNP		AGSVVMERIR		MDIRKVDAVF		VGTGDLFAAM		LLAWTHKHPN
NLKVACEKTV		STLHHVLQRT		IQCAKAQAGE		GVRPSPMQLE		LRMVQSKRDI
EDPEIVVQAT		VL

Funkcija

Protein kodiran ovim genom fosforilira vitamin B₆, korak potreban za konverziju vitamina B₆ u piridoksal-5-fosfat, važan kofaktor u posrednom metabolizmu. Kodirani protein je citoplazmatski] i vjerovatno djeluje kao homodimer. Opisane su alternativno prerađene varijante transkripta, ali njihova biološka valjanost nije utvrđena.

Dopunska literatura

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• Merrill AH, Henderson JM, Wang E, et al. (1984). "Metabolism of vitamin B-6 by human liver". J. Nutr. 114 (9): 1664–74. doi:10.1093/jn/114.9.1664. PMID 6088736.
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• Shin JH, Weitzdoerfer R, Fountoulakis M, Lubec G (2004). "Expression of cystathionine beta-synthase, pyridoxal kinase, and ES1 protein homolog (mitochondrial precursor) in fetal Down syndrome brain". Neurochem. Int. 45 (1): 73–9. doi:10.1016/j.neuint.2003.12.004. PMID 15082224. S2CID 20620865.
• Fang X, Zhou ZM, Lu L, et al. (2004). "Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis". Asian J. Androl. 6 (2): 83–91. PMID 15154080.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Flanagan JM, Beutler E (2006). "The genetic basis of human erythrocyte pyridoxal kinase activity variation". Haematologica. 91 (6): 801–4. PMID 16704963.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Musayev FN, di Salvo ML, Ko TP, et al. (2007). "Crystal Structure of human pyridoxal kinase: Structural basis of M+ and M2+ activation". Protein Sci. 16 (10): 2184–94. doi:10.1110/ps.073022107. PMC 2204131. PMID 17766369.