Mitohondrijski homolog proteina MTO1 jest protein koji je kod ljudi kodiran genom MTO1.[5][6]

MTO1
Identifikatori
AliasiMTO1
Vanjski ID-jeviOMIM: 614667 MGI: 1915541 HomoloGene: 5876 GeneCards: MTO1
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za MTO1
Genomska lokacija za MTO1
Bend6q13Početak73,461,578 bp[1]
Kraj73,509,236 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za MTO1
Genomska lokacija za MTO1
Bend9|9 E1Početak78,355,490 bp[2]
Kraj78,382,630 bp[2]
Ontologija gena
Molekularna funkcija flavin adenine dinucleotide binding
vezivanje sa RNK
Ćelijska komponenta mitohondrija
Biološki proces tRNA methylation
mitochondrial tRNA wobble uridine modification
tRNA processing
tRNA wobble uridine modification
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001123226
NM_012123
NM_133645

NM_026658

RefSeq (bjelančevina)

NP_001116698
NP_036255
NP_598400

NP_080934

Lokacija (UCSC)Chr 6: 73.46 – 73.51 MbChr 9: 78.36 – 78.38 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 717 aminokiselina, а molekulska težina 79.964 Da.[7]

1020304050
MFYFRGCGRWVAVSFTKQQFPLARLSSDSAAPRTPHFDVIVIGGGHAGTE
AATAAARCGSRTLLLTHRVDTIGQMSCNPSFGGIGKGHLMREVDALDGLC
SRICDQSGVHYKVLNRRKGPAVWGLRAQIDRKLYKQNMQKEILNTPLLTV
QEGAVEDLILTEPEPEHTGKCRVSGVVLVDGSTVYAESVILTTGTFLRGM
IVIGLETHPAGRLGDQPSIGLAQTLEKLGFVVGRLKTGTPPRIAKESINF
SILNKHIPDNPSIPFSFTNETVWIKPEDQLPCYLTHTNPRVDEIVLKNLH
LNSHVKETTRGPRYCPSIESKVLRFPNRLHQVWLEPEGMDSDLIYPQGLS
MTLPAELQEKMITCIRGLEKAKVIQPDGVLLLLPRMECNGAISAHHNLPL
PGYGVQYDYLDPRQITPSLETHLVQRLFFAGQINGTTGYEEAAAQGVIAG
INASLRVSRKPPFVVSRTEGYIGVLIDDLTTLGTSEPYRMFTSRVEFRLS
LRPDNADSRLTLRGYKDAGCVSQQRYERACWMKSSLEEGISVLKSIEFLS
SKWKKLIPEASISTSRSLPVRALDVLKYEEVDMDSLAKAVPEPLKKYTKC
RELAERLKIEATYESVLFHQLQEIKGVQQDEALQLPKDLDYLTIRDVSLS
HEVREKLHFSRPQTIGAASRIPGVTPAAIINLLRFVKTTQRRQSAMNESS
KTDQYLCDADRLQEREL

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135297 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032342 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Li X, Li R, Lin X, Guan MX (Jul 2002). "Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation". J Biol Chem. 277 (30): 27256–64. doi:10.1074/jbc.M203267200. PMID 12011058.
  6. ^ "Entrez Gene: MTO1 mitochondrial translation optimization 1 homolog (S. cerevisiae)".
  7. ^ "UniProt, Q9Y2Z2" (jezik: engleski). Pristupljeno 9. 10. 2021.

Dopunska literatura

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