Protein 3 sa HMG-kutijom jest protein koji je kod ljudi kodiran genom HMGXB3 sa hromosoma 5.[5]

HMGXB3
Identifikatori
AliasiHMGXB3
Vanjski ID-jeviMGI: 2441817 HomoloGene: 44229 GeneCards: HMGXB3
Lokacija gena (čovjek)
Hromosom 5 (čovjek)
Hrom.Hromosom 5 (čovjek)[1]
Hromosom 5 (čovjek)
Genomska lokacija za HMGXB3
Genomska lokacija za HMGXB3
Bend5q32Početak150,000,046 bp[1]
Kraj150,053,142 bp[1]
Lokacija gena (miš)
Hromosom 18 (miš)
Hrom.Hromosom 18 (miš)[2]
Hromosom 18 (miš)
Genomska lokacija za HMGXB3
Genomska lokacija za HMGXB3
Bend18|18 E1Početak61,264,349 bp[2]
Kraj61,310,122 bp[2]
Ontologija gena
Molekularna funkcija vezivanje sa DNK
kinase activity
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta jedro
ćelijska komponenta
Biološki proces Fosforilacija
GO:0022610 biološki proces
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_014983
NM_001366501

NM_134134
NM_178277

RefSeq (bjelančevina)

NP_055798
NP_001353430
NP_055798.2

n/a

Lokacija (UCSC)Chr 5: 150 – 150.05 MbChr 18: 61.26 – 61.31 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 1.538 aminokiselina, a molekulska težina 168.334[6] Da.[5]

1020304050
MQRTQPRPCYLNAPQQCPGAERPGRPTAGSHSFLLRPGPLAGSSPFALLD
PLQAFEQFVWVRSQARAGLLRLRQGSHAVTRCRPLPVRREGRRDGSPWRS
VVCRYCRCSRQTGASVTTVSLPSSSSSPGLDPRGPRQASVRSLRSEPVLL
FLPFRTPYRDSEEGKREGLSRLRAVCRRAGPRGRGSFSPRDARASPRLHF
LVAAVTTGAASRRQRGARVRQPSPSSSRRAKRLRECERRSLHAPPAMDAS
YDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYY
DIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDP
NSKLSALTAVVPDIPGFRKILPRSDYIIIPKSSLQEDRSCPQLELCVAQN
QMSPKGPPLVSNTAPETVPSHAGMAEQCLAVEALAEEVGALTQSGAVQEI
ATSEILSQDVLLEDASLEVGESHQPYQTSLVIEETLVNGSPDLPTGSLAV
PHPQVGESVSVVTVMRDSSESSSSAPATQFIMLPLPAYSVVENPTSIKLT
TTYTRRGHGTCTSPGCSFTYVTRHKPPKCPTCGNFLGGKWIPKEKPAKVK
VELASGVSSKGSVVKRNQQPVTTEQNSSKENASKLTLENSEAVSQLLNVA
PPREVGEESEWEEVIISDAHVLVKEAPGNCGTAVTKTPVVKSGVQPEVTL
GTTDNDSPGADVPTPSEGTSTSSPLPAPKKPTGADLLTPGSRAPELKGRA
RGKPSLLAAARPMRAILPAPVNVGRGSSMGLPRARQAFSLSDKTPSVRTC
GLKPSTLKQLGQPIQQPSGPGEVKLPSGPSNRTSQVKVVEVKPDMFPPYK
YSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRT
EKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQSTLQLLRKVLQIPENES
ELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSS
PLFKGGQNSLAGPQECWLLTASRLQTVTAQVKMCLNPHCLALHSFIDIYT
GLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTS
EELSQLQELLCNGYWAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVL
ALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASV
IAPFFPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIG
SYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARAIRPPRH
FTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMAT
SVALCADLCYPELTNQMWGRNQGCFSSPTEPPVSVSCPELLDQHYTVDMT
ETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATIL
ASIVDSKPNGVRQRPIAFDNATHYYLYNRLMDFLTSREIVNRQIHDIVQS
CQPGEVVIRDTLYRLGVAQIKTETEEEGEEEEVAAVAE

Funkcija

uredi

Protein kodiran ovim genom uključen u biološke procesa kao što je alternativna prerada RNK.

Protein ima mjesto vezivanja za DNK.
Lokaliziran je u jedru.

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113716 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024622 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: HMG-box containing 3". Pristupljeno 29. 3. 2016.
  6. ^ "UniProt, Q12766" (jezik: engleski). Pristupljeno 5. 9. 2017.

Dopunska literatura

uredi
  • NIH, ured. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14: 2121–2127. PubMed doi:10.1101/gr.2596504
  • Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3: 17–24.CS1 održavanje: upotreba parametra authors (link) PubMed doi:10.1093/dnares/3.1.17

Vanjski linkovi

uredi