To further elucidate the potential mechanisms of its anti-platelet property, relative expression of COX-2 and TXB [sub]2 and p38 mitogen-activated protein kinase (p38MAPK) and nuclear factor-kB (NF-kB) activities in human aortic endothelial cells (HAECs) stimulated by Ang II with or without pretreatment of valsartan were also determined.
TXA [sub]2 were represented by its metabolite TXB [sub]2 because it is unstable in common condition.
Effect of lead exposure on prostaglandins, endothelin (ET) and atrial natriuretic peptide (ANP): Cardenas et al (74) and Hotter et al (75) found a significant increase in urinary excretion of the metabolite of vasoconstrictive prostaglandin, thromboxan (
TXB,) when compared with values found in the control workers.