Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis

Atherosclerosis. 1998 Nov;141(1):1-15. doi: 10.1016/s0021-9150(98)00173-7.

Abstract

The oxidation hypothesis proposes that low density lipoprotein must be oxidatively modified to trigger the pathological events of atherosclerosis. In this article, we evaluate recent studies addressing the pathways that promote low density lipoprotein oxidation in vivo and the impact of antioxidants on atherogenesis in animals, paying particular attention to the clinical implications of these studies for the oxidation hypothesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Antioxidants / pharmacology
  • Arteries / metabolism
  • Arteriosclerosis / physiopathology*
  • Arteriosclerosis / prevention & control
  • Copper / metabolism
  • Humans
  • Iron / metabolism
  • Lipoproteins, LDL / physiology*
  • Lipoxygenase / metabolism
  • Nitric Oxide / metabolism
  • Oxidation-Reduction
  • Peroxidase / metabolism

Substances

  • Antioxidants
  • Lipoproteins, LDL
  • oxidized low density lipoprotein
  • Nitric Oxide
  • Copper
  • Iron
  • Peroxidase
  • Lipoxygenase