A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules

Immunity. 1997 Aug;7(2):273-82. doi: 10.1016/s1074-7613(00)80529-4.

Abstract

The human cytomegalovirus UL18 gene product is a homolog of cellular major histocompatibility (MHC) class I antigens. UL18 has been proposed to protect virus-infected cells against natural killer (NK) cell cytotoxicity by engaging NK cell killer inhibitory receptors (KIR) for MHC class I. UL18 binds to a novel immunoglobulin superfamily glycoprotein, designated Leukocyte Immunoglobulin-like Receptor (LIR-1). This protein is distinct from, but related to, known KIRs and binds cellular MHC class I antigens. The cytoplasmic domain of LIR-1 contains four putative immunoreceptor tyrosine-based inhibitory motifs. Upon tyrosine phosphorylation, LIR-1 associates with the tyrosine phosphatase SHP-1. In contrast to KIRs, LIR-1 is expressed predominantly on monocytic and B lymphoid cell types, suggesting a distinct biological function.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD*
  • B-Lymphocytes / metabolism
  • COS Cells
  • Capsid / metabolism
  • Capsid Proteins*
  • Cattle
  • Cytomegalovirus / immunology
  • Cytomegalovirus / metabolism
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Immunoglobulins / immunology
  • Immunoglobulins / metabolism*
  • Intracellular Signaling Peptides and Proteins
  • Killer Cells, Natural / metabolism
  • Leukocyte Immunoglobulin-like Receptor B1
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Monocytes / metabolism
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases / metabolism
  • Receptors, Immunologic / biosynthesis
  • Receptors, Immunologic / isolation & purification*
  • Receptors, Immunologic / metabolism
  • Receptors, Virus / biosynthesis
  • Receptors, Virus / isolation & purification*
  • Receptors, Virus / metabolism
  • Simplexvirus / metabolism
  • Viral Proteins / metabolism*

Substances

  • Antigens, CD
  • Capsid Proteins
  • Histocompatibility Antigens Class I
  • Immunoglobulins
  • Intracellular Signaling Peptides and Proteins
  • LILRB1 protein, human
  • Leukocyte Immunoglobulin-like Receptor B1
  • Receptors, Immunologic
  • Receptors, Virus
  • VP23 protein, Human herpesvirus 1
  • Viral Proteins
  • PTPN11 protein, human
  • PTPN6 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases
  • Ptpn11 protein, mouse
  • Ptpn6 protein, mouse

Associated data

  • GENBANK/AF009220
  • GENBANK/AF009221