Abstract
CD94 receptors expressed on NK cells have been implicated in the recognition of certain HLA class I allotypes. We now demonstrate that CD94 glycoproteins form disulfide-bonded heterodimers with the NKG2A/B, NKG2C, and NKG2E glycoproteins. NKG2A/B possesses two immunoreceptor tyrosine-based inhibition motif (ITIM) sequences in its cytoplasmic domain, which may be responsible for the inhibitory function of these receptors, whereas other NKG2 proteins lack ITIMs and may potentially transmit positive signals. Structural heterogeneity in the NKG2 gene family and the formation of heterodimers with CD94 provides for the creation of a diverse NK cell repertoire.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antibodies
-
Antibodies, Monoclonal
-
Antigens, CD / chemistry*
-
Antigens, CD / genetics
-
Antigens, CD / metabolism
-
Cell Line
-
Disulfides / chemistry
-
HLA Antigens / metabolism
-
Histocompatibility Antigens Class I / metabolism*
-
Humans
-
Killer Cells, Natural / immunology*
-
Lectins, C-Type*
-
Membrane Glycoproteins / chemistry*
-
Membrane Glycoproteins / genetics
-
Membrane Glycoproteins / metabolism
-
Mice
-
Molecular Weight
-
NK Cell Lectin-Like Receptor Subfamily C
-
NK Cell Lectin-Like Receptor Subfamily D
-
Protein Conformation
-
Rabbits
-
Receptors, Immunologic*
-
Receptors, Natural Killer Cell
-
Transfection
-
Tyrosine / chemistry
Substances
-
Antibodies
-
Antibodies, Monoclonal
-
Antigens, CD
-
Disulfides
-
HLA Antigens
-
Histocompatibility Antigens Class I
-
KLRC1 protein, human
-
KLRC2 protein, human
-
KLRC3 protein, human
-
KLRD1 protein, human
-
Klrc1 protein, mouse
-
Klrc2 protein, mouse
-
Klrc3 protein, mouse
-
Klrd1 protein, mouse
-
Lectins, C-Type
-
Membrane Glycoproteins
-
NK Cell Lectin-Like Receptor Subfamily C
-
NK Cell Lectin-Like Receptor Subfamily D
-
Receptors, Immunologic
-
Receptors, Natural Killer Cell
-
Tyrosine