The term "nanoparticle stability" is widely used to describe the preservation of a particular nanostructure property ranging from aggregation, composition, crystallinity, shape, size, and surface chemistry. As a result, this catch-all term has various meanings, which depend on the specific nanoparticle property of interest and/or application. In this feature article, we provide an answer to the question, "What does nanoparticle stability mean?". Broadly speaking, the definition of nanoparticle stability depends on the targeted size dependent property that is exploited and can only exist for a finite period of time given all nanostructures are inherently thermodynamically and energetically unfavorable relative to bulk states. To answer this question specifically, however, the relationship between nanoparticle stability and the physical/chemical properties of metal/metal oxide nanoparticles are discussed. Specific definitions are explored in terms of aggregation state, core composition, shape, size, and surface chemistry. Next, mechanisms of promoting nanoparticle stability are defined and related to these same nanoparticle properties. Metrics involving both kinetics and thermodynamics are considered. Methods that provide quantitative metrics for measuring and modeling nanoparticle stability in terms of core composition, shape, size, and surface chemistry are outlined. The stability of solution-phase nanoparticles are also impacted by aggregation state. Thus, collision and DLVO theories are discussed. Finally, challenges and opportunities in understanding what nanoparticle stability means are addressed to facilitate further studies with this important class of materials.