Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease

Shen Gao; Jing Liu

doi:10.1016/j.cdtm.2017.02.008

Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease

Chronic Dis Transl Med. 2017 May 25;3(2):89-94. doi: 10.1016/j.cdtm.2017.02.008. eCollection 2017 Jun 25.

Authors

Shen Gao¹, Jing Liu¹

Affiliation

¹ Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.

Abstract

Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD). Numerous studies have demonstrated an atherogenic role of oxidized low-density lipoprotein (ox-LDL) in the progression of ASCVD. This article briefly reviews the atherogenic mechanism of ox-LDL, the methods of measuring ox-LDL in the circulation, effect of medical therapy and life-style modification on ox-LDL level, and the association between circulating ox-LDL and atherosclerosis, including clinical ASCVD events and subclinical atherosclerosis, in observational studies.

Keywords: Atherosclerosis; Cardiovascular disease; Oxidized low density lipoprotein; Review; Subclinical atherosclerosis.

Publication types

Review