Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity

J Invest Dermatol. 2017 Nov;137(11):2257-2259. doi: 10.1016/j.jid.2017.08.026.

Abstract

Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-del) is a psoriasis risk factor linked to the major psoriasis risk gene HLA-C*06. Niehues et al. demonstrate that LCE3B/C-del leads to increased keratinocyte LCE3A expression. They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regulate epidermal barrier integrity. These findings implicate LCE proteins in psoriasis pathogenesis via a new functional role.

Publication types

  • Comment

MeSH terms

  • Anti-Infective Agents / therapeutic use
  • Case-Control Studies
  • Cornified Envelope Proline-Rich Proteins / genetics*
  • Female
  • Gene Expression Regulation*
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Polymorphism, Single Nucleotide*
  • Psoriasis / drug therapy*
  • Psoriasis / genetics*
  • Sensitivity and Specificity

Substances

  • Anti-Infective Agents
  • Cornified Envelope Proline-Rich Proteins
  • LCE3A protein, human
  • LCE3B protein, human
  • LCE3C protein, human