Plasmid-borne colistin resistance gene mcr-3 in Salmonella isolates from human infections, Denmark, 2009-17

Euro Surveill. 2017 Aug 3;22(31):30587. doi: 10.2807/1560-7917.ES.2017.22.31.30587.

Abstract

This report describes one Salmonella isolate harbouring both mcr-1 and mcr-3. We also found nine other Salmonella isolates positive for the plasmid-borne colistin resistance gene, mcr-3. The strains were isolated from patients in Denmark between 2009 and 2017 and five of the patients had travelled to Asia. In addition to mcr-3, all strains were found positive for blaTEM-1, strA, strB, sul2 and tet(A) or tet(B), and most strains were positive for blaCTX-M-55 and qnrS.

Keywords: ESBL; Salmonella; antimicrobial resistance; colistin resistance; mcr-3; plasmid.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Chickens / microbiology*
  • Colistin / pharmacology*
  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / genetics
  • Escherichia coli / isolation & purification*
  • Humans
  • Meat / microbiology*
  • Microbial Sensitivity Tests
  • Plasmids / genetics*
  • Salmonella / drug effects*
  • Salmonella / genetics
  • Salmonella / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Colistin