Proliferation centres of chronic lymphocytic leukaemia/small lymphocytic lymphoma have enhanced expression of MYC protein, which does not result from rearrangement or gain of the MYC gene

Br J Haematol. 2016 Oct;175(1):173-5. doi: 10.1111/bjh.13844. Epub 2015 Nov 16.

Authors

Sarah E Gibson^{1

2}, Rebecca J Leeman-Neill^{3

4}, Sarika Jain^{3

4}, Wenhua Piao⁴, Kathleen M Cieply⁴, Steven H Swerdlow^{3

4}

Affiliations

¹ University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. [email protected].
² University of Pittsburgh Medical Center, Pittsburgh, PA, USA. [email protected].
³ University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
⁴ University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

PMID: 26568397
DOI: 10.1111/bjh.13844

No abstract available

Keywords: B-cell receptor; CLL/SLL; MYC gene; MYC protein; chronic lymphocytic leukaemia/small lymphocytic lymphoma.

Publication types

Letter

MeSH terms

Cell Proliferation*
Cytogenetics
Gene Expression Regulation, Leukemic
Genes, myc
Immunohistochemistry
Immunophenotyping
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
Proto-Oncogene Proteins c-myc / genetics*
Up-Regulation

Substances

MYC protein, human
Proto-Oncogene Proteins c-myc