Abstract
The beta(1-3)glucanosyltransferase GEL family of Aspergillus fumigatus contains 7 genes, among which only 3 are expressed during mycelial growth. The role of the GEL4 gene was investigated in this study. Like the other Gelps, it encodes a glycosylphosphatidylinositol (GPI)-anchored protein. In contrast to the other beta(1-3)glucanosyltransferases analyzed to date, it is essential for this fungal species.
MeSH terms
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Aspergillus fumigatus / enzymology*
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Aspergillus fumigatus / genetics
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Aspergillus fumigatus / growth & development
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Chromatography, Ion Exchange
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Gene Deletion
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Gene Expression Regulation, Enzymologic
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Gene Expression Regulation, Fungal
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Genes, Essential* / genetics
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Genes, Fungal / genetics
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Glucan Endo-1,3-beta-D-Glucosidase / genetics
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Glucan Endo-1,3-beta-D-Glucosidase / metabolism*
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Glycosylphosphatidylinositols / metabolism
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Mycelium / enzymology
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Mycelium / genetics
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Mycelium / growth & development
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Phylogeny
Substances
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Fungal Proteins
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Glycosylphosphatidylinositols
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Glucan Endo-1,3-beta-D-Glucosidase