Abstract
In a study of cytokine production ex vivo by Borrelia burgdorferi-stimulated peripheral blood mononuclear cells from 27 patients with culture-positive erythema migrans, production of inflammatory cytokines predominated, particularly gamma interferon and, to a lesser degree, tumor necrosis factor alpha. In contrast, with the exception of interleukin-13, anti-inflammatory cytokine production was negligible. Thus, B. burgdorferi antigens in early Lyme disease often induce a strong inflammatory response.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antigens, Bacterial / administration & dosage
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Antigens, Surface / administration & dosage
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Antigens, Surface / immunology
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Bacterial Outer Membrane Proteins / administration & dosage
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Bacterial Outer Membrane Proteins / immunology
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Bacterial Vaccines
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Borrelia burgdorferi / immunology
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Cytokines / biosynthesis*
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Erythema Chronicum Migrans / immunology*
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Female
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Humans
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In Vitro Techniques
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Inflammation Mediators / metabolism*
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Leukocytes, Mononuclear / immunology
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Lipoproteins*
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Lymphocyte Activation
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Male
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Middle Aged
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T-Lymphocytes / immunology
Substances
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Antigens, Bacterial
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Antigens, Surface
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Bacterial Outer Membrane Proteins
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Bacterial Vaccines
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Cytokines
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Inflammation Mediators
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Lipoproteins
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OspA protein
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OspC protein