Abstract
Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Active Transport, Cell Nucleus / physiology
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Animals
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Apoptosis / physiology*
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Cell Compartmentation / physiology*
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Cell Cycle / physiology
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Cell Division / physiology
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Gene Expression Regulation, Neoplastic / genetics
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Gene Expression Regulation, Neoplastic / physiology
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Humans
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Mutation / genetics
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Neoplasms / pathology*
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Neoplasms / physiopathology*
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transcription, Genetic / genetics
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Transcription, Genetic / physiology*
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism*
Substances
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Transcription Factors
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Tumor Suppressor Protein p53