Abstract
Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Apoptosis*
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CD36 Antigens / genetics
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CD36 Antigens / physiology*
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Carrier Proteins / physiology
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Drosophila / cytology
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Drosophila / embryology*
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Drosophila / physiology
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Drosophila Proteins*
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Embryo, Nonmammalian / cytology
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Embryo, Nonmammalian / physiology
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Escherichia coli / immunology
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Gene Deletion
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Gene Expression Regulation, Developmental
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Genes, Insect
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Ion Pumps*
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Macrophages / physiology*
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Membrane Proteins / physiology
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Phagocytosis*
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Phenotype
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Receptors, Immunologic / genetics
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Receptors, Immunologic / physiology*
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Receptors, Scavenger
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Staphylococcus aureus / immunology
Substances
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CD36 Antigens
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Carrier Proteins
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Drosophila Proteins
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Ion Pumps
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Membrane Proteins
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Receptors, Immunologic
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Receptors, Scavenger
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crq protein, Drosophila
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mvl protein, Drosophila