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Suggested authors matching "AUTH:Wicht KJ" with an ORCID

Kathryn J. Wicht
University of Cape Town
16
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658
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Author Correction: Antimalarial drug discovery: progress and approaches.
Siqueira-Neto JL, Wicht KJ, Chibale K, Burrows JN, Fidock DA, Winzeler EA
Nat Rev Drug Discov, 23(11):880, 01 Nov 2024
Cited by: 0 articles | PMID: 39271962
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2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of <i>Plasmodium falciparum</i> Phosphatidylinositol-4-kinase and Hemozoin Formation with <i>In Vivo</i> Efficacy.
Dziwornu GA, Seanego D, Fienberg S, Clements M, Ferreira J, Sypu VS, Samanta S, Bhana AD, Korkor CM, Garnie LF, Teixeira N, Wicht KJ, Taylor D, Olckers R, Njoroge M, Gibhard L, Salomane N, Wittlin S, Mahato R, [...] Chibale K
J Med Chem, 67(13):11401-11420, 25 Jun 2024
Cited by: 1 article | PMID: 38918002 | PMCID: PMC11247499
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole.
Mambwe D, Coertzen D, Leshabane M, Mulubwa M, Njoroge M, Gibhard L, Girling G, Wicht KJ, Lee MCS, Wittlin S, Moreira DRM, Birkholtz LM, Chibale K
ACS Med Chem Lett, 15(4):463-469, 18 Mar 2024
Cited by: 0 articles | PMID: 38628794 | PMCID: PMC11017395
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Drug discovery in Africa tackles zoonotic and related infections.
Hikaambo CN, Shakela N, Woodland JG, Wicht KJ, Chibale K
Sci Transl Med, 15(718):eadj0035, 18 Oct 2023
Cited by: 0 articles | PMID: 37851825
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Antimalarial drug discovery: progress and approaches.
Siqueira-Neto JL, Wicht KJ, Chibale K, Burrows JN, Fidock DA, Winzeler EA
Nat Rev Drug Discov, 22(10):807-826, 31 Aug 2023
Cited by: 19 articles | PMID: 37652975 | PMCID: PMC10543600
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Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum, and Synergize with Clinical Antimalarials.
Okombo J, Kumar M, Redhi D, Wicht KJ, Wiesner L, Egan TJ, Chibale K
ACS Infect Dis, 9(3):653-667, 20 Feb 2023
Cited by: 0 articles | PMID: 36802523
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Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches.
Amod L, Mohunlal R, Teixeira N, Egan TJ, Wicht KJ
Sci Rep, 13(1):2648, 14 Feb 2023
Cited by: 2 articles | PMID: 36788274 | PMCID: PMC9929333
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Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches
Amod L, Mohunlal R, Teixeira N, Egan TJ, Wicht KJ
Research Square, 08 Dec 2022
Cited by: 0 articles | PPR: PPR581633
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Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials.
Wicht KJ, Small-Saunders JL, Hagenah LM, Mok S, Fidock DA
J Infect Dis, 226(11):2021-2029, 01 Nov 2022
Cited by: 15 articles | PMID: 36082431 | PMCID: PMC9704436
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Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.
Small-Saunders JL, Hagenah LM, Wicht KJ, Dhingra SK, Deni I, Kim J, Vendome J, Gil-Iturbe E, Roepe PD, Mehta M, Mancia F, Quick M, Eppstein MJ, Fidock DA
PLoS Pathog, 18(2):e1010278, 07 Feb 2022
Cited by: 17 articles | PMID: 35130315 | PMCID: PMC8853508
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Medicinal Chemistry Out of Africa.
Chibale K, Wicht KJ, Woodland JG
J Med Chem, 64(15):10513-10516, 23 Jul 2021
Cited by: 3 articles | PMID: 34296862
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The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Murithi JM, Deni I, Pasaje CFA, Okombo J, Bridgford JL, Gnädig NF, Edwards RL, Yeo T, Mok S, Burkhard AY, Coburn-Flynn O, Istvan ES, Sakata-Kato T, Gomez-Lorenzo MG, Cowell AN, Wicht KJ, Le Manach C, Kalantarov GF, Dey S, [...] Fidock DA
Cell Chem Biol, 29(5):824-839.e6, 06 Jul 2021
Cited by: 12 articles | PMID: 34233174 | PMCID: PMC8727639
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Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
Dorjsuren D, Eastman RT, Wicht KJ, Jansen D, Talley DC, Sigmon BA, Zakharov AV, Roncal N, Girvin AT, Antonova-Koch Y, Will PM, Shah P, Sun H, Klumpp-Thomas C, Mok S, Yeo T, Meister S, Marugan JJ, Ross LS, [...] Fidock DA
Sci Rep, 11(1):2121, 22 Jan 2021
Cited by: 11 articles | PMID: 33483532 | PMCID: PMC7822874
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Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
Le Manach C, Dam J, Woodland JG, Kaur G, Khonde LP, Brunschwig C, Njoroge M, Wicht KJ, Horatscheck A, Paquet T, Boyle GA, Gibhard L, Taylor D, Lawrence N, Yeo T, Mok S, Eastman RT, Dorjsuren D, Talley DC, [...] Chibale K
J Med Chem, 64(4):2291-2309, 12 Feb 2021
Cited by: 7 articles | PMID: 33573376
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Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.
Wicht KJ, Mok S, Fidock DA
Annu Rev Microbiol, 74:431-454, 01 Sep 2020
Cited by: 109 articles | PMID: 32905757 | PMCID: PMC8130186
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Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.
Vanaerschot M, Murithi JM, Pasaje CFA, Ghidelli-Disse S, Dwomoh L, Bird M, Spottiswoode N, Mittal N, Arendse LB, Owen ES, Wicht KJ, Siciliano G, Bösche M, Yeo T, Kumar TRS, Mok S, Carpenter EF, Giddins MJ, Sanz O, [...] Fidock DA
Cell Chem Biol, 27(7):806-816.e8, 30 Apr 2020
Cited by: 41 articles | PMID: 32359426 | PMCID: PMC7369637
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Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Kim J, Tan YZ, Wicht KJ, Erramilli SK, Dhingra SK, Okombo J, Vendome J, Hagenah LM, Giacometti SI, Warren AL, Nosol K, Roepe PD, Potter CS, Carragher B, Kossiakoff AA, Quick M, Fidock DA, Mancia F
Nature, 576(7786):315-320, 27 Nov 2019
Cited by: 93 articles | PMID: 31776516 | PMCID: PMC6911266
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Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ ^null Mouse Model of Malaria.
Nchinda AT, Le Manach C, Paquet T, Gonzàlez Cabrera D, Wicht KJ, Brunschwig C, Njoroge M, Abay E, Taylor D, Lawrence N, Wittlin S, Jiménez-Díaz MB, Santos Martínez M, Ferrer S, Angulo-Barturen I, Lafuente-Monasterio MJ, Duffy J, Burrows J, Street LJ, Chibale K
J Med Chem, 61(9):4213-4227, 27 Apr 2018
Cited by: 5 articles | PMID: 29665687
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Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.
Ross LS, Dhingra SK, Mok S, Yeo T, Wicht KJ, Kümpornsin K, Takala-Harrison S, Witkowski B, Fairhurst RM, Ariey F, Menard D, Fidock DA
Nat Commun, 9(1):3314, 17 Aug 2018
Cited by: 142 articles | PMID: 30115924 | PMCID: PMC6095916
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Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum.
Wicht KJ, Combrinck JM, Smith PJ, Hunter R, Egan TJ
ACS Med Chem Lett, 8(2):201-205, 24 Jan 2017
Cited by: 8 articles | PMID: 28197312 | PMCID: PMC5304302
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Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.
Wicht KJ, Combrinck JM, Smith PJ, Hunter R, Egan TJ
J Med Chem, 59(13):6512-6530, 24 Jun 2016
Cited by: 12 articles | PMID: 27299916 | PMCID: PMC4945415
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N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity.
Figueiras M, Coelho L, Wicht KJ, Santos SA, Lavrado J, Gut J, Rosenthal PJ, Nogueira F, Egan TJ, Moreira R, Paulo A
Bioorg Med Chem, 23(7):1530-1539, 13 Feb 2015
Cited by: 2 articles | PMID: 25725608
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Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains.
Chugh M, Scheurer C, Sax S, Bilsland E, van Schalkwyk DA, Wicht KJ, Hofmann N, Sharma A, Bashyam S, Singh S, Oliver SG, Egan TJ, Malhotra P, Sutherland CJ, Beck HP, Wittlin S, Spangenberg T, Ding XC
Antimicrob Agents Chemother, 59(2):1110-1118, 08 Dec 2014
Cited by: 20 articles | PMID: 25487796 | PMCID: PMC4335906
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Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity.
Wicht KJ, Combrinck JM, Smith PJ, Egan TJ
Bioorg Med Chem, 23(16):5210-5217, 20 Dec 2014
Cited by: 12 articles | PMID: 25573118 | PMCID: PMC4475507
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Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity.
Sandlin RD, Fong KY, Wicht KJ, Carrell HM, Egan TJ, Wright DW
Int J Parasitol Drugs Drug Resist, 4(3):316-325, 11 Sep 2014
Cited by: 24 articles | PMID: 25516843 | PMCID: PMC4266794
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Search life-sciences literature (45,100,050 articles, preprints and more)

Suggested authors matching "AUTH:Wicht KJ" with an ORCID

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Author Correction: Antimalarial drug discovery: progress and approaches.

2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of <i>Plasmodium falciparum</i> Phosphatidylinositol-4-kinase and Hemozoin Formation with <i>In Vivo</i> Efficacy.

hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole.

Drug discovery in Africa tackles zoonotic and related infections.

Antimalarial drug discovery: progress and approaches.

Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum, and Synergize with Clinical Antimalarials.

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches.

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches

Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials.

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.

Medicinal Chemistry Out of Africa.

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ ^null Mouse Model of Malaria.

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.

Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum.

Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.

N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity.

Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains.

Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity.

Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity.

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