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Search life-sciences literature (45,104,206 articles, preprints and more)

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Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.
Vanrusselt H, Kum DB, Taverniti V, Liu C, Acosta Sanchez A, Corthout N, Munck S, Baumert TF, Beigelman L, Blatt LM, Symons JA, Deval J, Raboisson P, Verrier ER, Jekle A, Vendeville S, Debing Y
J Virol, 97(10):e0072223, 27 Sep 2023
Cited by: 2 articles | PMID: 37754761 | PMCID: PMC10617565
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Granulocyte colony stimulating factor in decompensated cirrhosis, acute alcoholic hepatitis, and acute-on-chronic liver failure: A comprehensive meta-analysis of randomized controlled trials.
Di Martino V, Questiaux J, Lemagoarou T, Weil D, Vendeville S, Engelmann C, Hu J, Singh V, Newsome PN, Lal SB, Sarin SK, Berg T, Thevenot T
Clin Res Hepatol Gastroenterol, 47(9):102207, 15 Sep 2023
Cited by: 1 article | PMID: 37716522
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Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Kum DB, Vanrusselt H, Acosta Sanchez A, Taverniti V, Verrier ER, Baumert TF, Liu C, Deval J, Corthout N, Munck S, Beigelman L, Blatt LM, Symons JA, Raboisson P, Jekle A, Vendeville S, Debing Y
Hepatology, 78(4):1252-1265, 28 Apr 2023
Cited by: 7 articles | PMID: 37102495
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Systematic screening for advanced liver fibrosis in patients with coronary artery disease: The CORONASH study.
Thévenot T, Vendeville S, Weil D, Akkouche L, Calame P, Canivet CM, Vanlemmens C, Richou C, Cervoni JP, Seronde MF, Di Martino V, Boursier J
PLoS One, 17(5):e0266965, 26 May 2022
Cited by: 6 articles | PMID: 35617294 | PMCID: PMC9135299
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus.
Vendeville S, Tahri A, Hu L, Demin S, Cooymans L, Vos A, Kwanten L, Van den Berg J, Battles MB, McLellan JS, Koul A, Raboisson P, Roymans D, Jonckers THM
J Med Chem, 63(15):8046-8058, 15 Jun 2020
Cited by: 8 articles | PMID: 32407115
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Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor.
Roymans D, Alnajjar SS, Battles MB, Sitthicharoenchai P, Furmanova-Hollenstein P, Rigaux P, Berg JVD, Kwanten L, Ginderen MV, Verheyen N, Vranckx L, Jaensch S, Arnoult E, Voorzaat R, Gallup JM, Larios-Mora A, Crabbe M, Huntjens D, Raboisson P, [...] Koul A
Nat Commun, 8(1):167, 01 Aug 2017
Cited by: 42 articles | PMID: 28761099 | PMCID: PMC5537225
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Discovery and development of simeprevir (TMC435), a HCV NS3/4A protease inhibitor.
Rosenquist Å, Samuelsson B, Johansson PO, Cummings MD, Lenz O, Raboisson P, Simmen K, Vendeville S, de Kock H, Nilsson M, Horvath A, Kalmeijer R, de la Rosa G, Beumont-Mauviel M
J Med Chem, 57(5):1673-1693, 14 Feb 2014
Cited by: 75 articles | PMID: 24446688
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Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Cummings MD, Lin TI, Hu L, Tahri A, McGowan D, Amssoms K, Last S, Devogelaere B, Rouan MC, Vijgen L, Berke JM, Dehertogh P, Fransen E, Cleiren E, van der Helm L, Fanning G, Nyanguile O, Simmen K, Van Remoortere P, [...] Vendeville S
J Med Chem, 57(5):1880-1892, 08 Nov 2013
Cited by: 12 articles | PMID: 24144360
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TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.
Devogelaere B, Berke JM, Vijgen L, Dehertogh P, Fransen E, Cleiren E, van der Helm L, Nyanguile O, Tahri A, Amssoms K, Lenz O, Cummings MD, Clayton RF, Vendeville S, Raboisson P, Simmen KA, Fanning GC, Lin TI
Antimicrob Agents Chemother, 56(9):4676-4684, 18 Jun 2012
Cited by: 18 articles | PMID: 22710121 | PMCID: PMC3421868
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Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
McGowan D, Vendeville S, Lin TI, Tahri A, Hu L, Cummings MD, Amssoms K, Berke JM, Canard M, Cleiren E, Dehertogh P, Last S, Fransen E, Van Der Helm E, Van den Steen I, Vijgen L, Rouan MC, Fanning G, Nyanguile O, [...] Raboisson P
Bioorg Med Chem Lett, 22(13):4431-4436, 03 Apr 2012
Cited by: 5 articles | PMID: 22542193
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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.
Vendeville S, Lin TI, Hu L, Tahri A, McGowan D, Cummings MD, Amssoms K, Canard M, Last S, Van den Steen I, Devogelaere B, Rouan MC, Vijgen L, Berke JM, Dehertogh P, Fransen E, Cleiren E, van der Helm L, Fanning G, [...] Raboisson P
Bioorg Med Chem Lett, 22(13):4437-4443, 30 Apr 2012
Cited by: 12 articles | PMID: 22633687
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Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
Cummings MD, Lin TI, Hu L, Tahri A, McGowan D, Amssoms K, Last S, Devogelaere B, Rouan MC, Vijgen L, Berke JM, Dehertogh P, Fransen E, Cleiren E, van der Helm L, Fanning G, Van Emelen K, Nyanguile O, Simmen K, [...] Vendeville S
Angew Chem Int Ed Engl, 51(19):4637-4640, 30 Mar 2012
Cited by: 8 articles | PMID: 22473861
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1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus.
Nyanguile O, Devogelaere B, Vijgen L, Van den Broeck W, Pauwels F, Cummings MD, De Bondt HL, Vos AM, Berke JM, Lenz O, Vandercruyssen G, Vermeiren K, Mostmans W, Dehertogh P, Delouvroy F, Vendeville S, VanDyck K, Dockx K, Cleiren E, [...] Fanning GC
J Virol, 84(6):2923-2934, 13 Jan 2010
Cited by: 23 articles | PMID: 20071590 | PMCID: PMC2826027
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Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase.
Vandyck K, Cummings MD, Nyanguile O, Boutton CW, Vendeville S, McGowan D, Devogelaere B, Amssoms K, Last S, Rombauts K, Tahri A, Lory P, Hu L, Beauchamp DA, Simmen K, Raboisson P
J Med Chem, 52(14):4099-4102, 01 Jul 2009
Cited by: 20 articles | PMID: 19507864
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1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.
McGowan D, Nyanguile O, Cummings MD, Vendeville S, Vandyck K, Van den Broeck W, Boutton CW, De Bondt H, Quirynen L, Amssoms K, Bonfanti JF, Last S, Rombauts K, Tahri A, Hu L, Delouvroy F, Vermeiren K, Vandercruyssen G, Van der Helm L, [...] Raboisson P
Bioorg Med Chem Lett, 19(9):2492-2496, 14 Mar 2009
Cited by: 12 articles | PMID: 19342234
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Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors.
Raboisson P, Lin TI, Kock Hd, Vendeville S, Vreken WV, McGowan D, Tahri A, Hu L, Lenz O, Delouvroy F, Surleraux D, Wigerinck P, Nilsson M, Rosenquist S, Samuelsson B, Simmen K
Bioorg Med Chem Lett, 18(18):5095-5100, 03 Aug 2008
Cited by: 11 articles | PMID: 18722116
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Zirconia: Established facts and perspectives for a biomaterial in dental implantology.
Hisbergues M, Vendeville S, Vendeville P
J Biomed Mater Res B Appl Biomater, 88(2):519-529, 01 Feb 2009
Cited by: 96 articles | PMID: 18561291
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Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.
Vendeville S, Nilsson M, de Kock H, Lin TI, Antonov D, Classon B, Ayesa S, Ivanov V, Johansson PO, Kahnberg P, Eneroth A, Wikstrom K, Vrang L, Edlund M, Lindström S, Van de Vreken W, McGowan D, Tahri A, Hu L, [...] Raboisson P
Bioorg Med Chem Lett, 18(23):6189-6193, 05 Oct 2008
Cited by: 8 articles | PMID: 18954982
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Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.
Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wähling H, Wickström K, Hamelink E, Edlund M, Vrang L, Vendeville S, Van de Vreken W, McGowan D, Tahri A, Hu L, Boutton C, [...] Simmen K
Bioorg Med Chem Lett, 18(17):4853-4858, 24 Jul 2008
Cited by: 47 articles | PMID: 18678486
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Design of HIV-1 protease inhibitors active on multidrug-resistant virus.
Surleraux DL, de Kock HA, Verschueren WG, Pille GM, Maes LJ, Peeters A, Vendeville S, De Meyer S, Azijn H, Pauwels R, de Bethune MP, King NM, Prabu-Jeyabalan M, Schiffer CA, Wigerinck PB
J Med Chem, 48(6):1965-1973, 01 Mar 2005
Cited by: 39 articles | PMID: 15771440
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Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases.
Vendeville S, Goossens F, Debreu-Fontaine MA, Landry V, Davioud-Charvet E, Grellier P, Scharpe S, Sergheraert C
Bioorg Med Chem, 10(6):1719-1729, 01 Jun 2002
Cited by: 10 articles | PMID: 11937331
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Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes.
Grellier P, Vendeville S, Joyeau R, Bastos IM, Drobecq H, Frappier F, Teixeira AR, Schrével J, Davioud-Charvet E, Sergheraert C, Santana JM
J Biol Chem, 276(50):47078-47086, 11 Oct 2001
Cited by: 64 articles | PMID: 11598112
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Identification of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library.
Vendeville S, Buisine E, Williard X, Schrevel J, Grellier P, Santana J, Sergheraert C
Chem Pharm Bull (Tokyo), 47(2):194-198, 01 Feb 1999
Cited by: 10 articles | PMID: 10071854
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Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors.
Vendeville S, Bourel L, Davioud-Charvet E, Grellier P, Deprez B, Sergheraert C
Bioorg Med Chem Lett, 9(3):437-442, 01 Feb 1999
Cited by: 6 articles | PMID: 10091698
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1-24 of 24 results

Search life-sciences literature (45,104,206 articles, preprints and more)

Search results

Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.

Granulocyte colony stimulating factor in decompensated cirrhosis, acute alcoholic hepatitis, and acute-on-chronic liver failure: A comprehensive meta-analysis of randomized controlled trials.

Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.

Systematic screening for advanced liver fibrosis in patients with coronary artery disease: The CORONASH study.

Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus.

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor.

Discovery and development of simeprevir (TMC435), a HCV NS3/4A protease inhibitor.

Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.

TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.

Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.

Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.

1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus.

Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase.

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.

Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors.

Zirconia: Established facts and perspectives for a biomaterial in dental implantology.

Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.

Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.

Design of HIV-1 protease inhibitors active on multidrug-resistant virus.

Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases.

Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes.

Identification of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library.

Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors.

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