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Search life-sciences literature (45,103,589 articles, preprints and more)

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KIR2DL2/DL3+NKs and Helios+Tregs in Peripheral Blood Predict Nivolumab Response in Patients with Metastatic Renal Cell Cancer.
Santagata S, Trotta AM, D'Alterio C, Napolitano M, Rea G, Di Napoli M, Portella L, Ieranò C, Guardascione G, Coppola E, Caux C, Dubois B, Boyle HJ, Carles J, Rossetti S, Azzaro R, Feroce F, Perdonà S, Fordellone M, [...] Scala S
Clin Cancer Res, 30(20):4755-4767, 01 Oct 2024
Cited by: 0 articles | PMID: 39167621 | PMCID: PMC11474171
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Comprehensive structural investigation of a potent and selective CXCR4 antagonist via crosslink modification.
Trotta AM, Mazzarella V, Roggia M, D'Aniello A, Del Bene A, Vetrei C, Di Maiolo G, Campagna E, Natale B, Rea G, Santagata S, D'Alterio C, Cutolo R, Mottola S, Merlino F, Benedetti R, Altucci L, Messere A, Cosconati S, [...] Di Maro S
Eur J Med Chem, 279:116911, 25 Sep 2024
Cited by: 0 articles | PMID: 39348763
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CXCL12-loaded-hydrogel (CLG): A new device for metastatic circulating tumor cells (CTCs) capturing and characterization.
Portella L, Bertolini G, Guardascione G, Di Febbraro DG, Ieranò C, D'Alterio C, Rea G, Napolitano M, Santagata S, Trotta AM, Camerlingo R, Scarpa E, Cecere SC, Ottaiano A, Palumbo G, Morabito A, Somma T, De Rosa G, Mayol L, [...] Scala S
Heliyon, 10(15):e35524, 31 Jul 2024
Cited by: 0 articles | PMID: 39170328 | PMCID: PMC11336720
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Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites.
Trotta AM, Tomassi S, Di Maiolo G, Ieranò C, Vetrei C, D'Alterio C, Merlino F, Messere A, D'Aniello A, Del Bene A, Mazzarella V, Roggia M, Natale B, Cutolo R, Campagna E, Mottola S, Russo R, Chambery A, Benedetti R, [...] Di Maro S
Eur J Med Chem, 276:116669, 14 Jul 2024
Cited by: 0 articles | PMID: 39053189
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Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients.
Santagata S, Rea G, Bello AM, Capiluongo A, Napolitano M, Desicato S, Fragale A, D'Alterio C, Trotta AM, Ieranò C, Portella L, Persico F, Di Napoli M, Di Maro S, Feroce F, Azzaro R, Gabriele L, Longo N, Pignata S, [...] Scala S
Br J Cancer, 130(12):2016-2026, 04 May 2024
Cited by: 1 article | PMID: 38704478 | PMCID: PMC11183124
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Hepatocellular carcinoma (HCC) tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) tumor microenvironment.
Santagata S, Rea G, Castaldo D, Napolitano M, Capiluongo A, D'Alterio C, Trotta AM, Ieranò C, Portella L, Di Maro S, Tatangelo F, Albino V, Guarino R, Cutolo C, Izzo F, Scala S
Hepatol Int, 18(2):568-581, 04 May 2023
Cited by: 4 articles | PMID: 37142825 | PMCID: PMC11014815
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Oligo-Metastatic Cancers: Putative Biomarkers, Emerging Challenges and New Perspectives.
Ottaiano A, Santorsola M, Circelli L, Trotta AM, Izzo F, Perri F, Cascella M, Sabbatino F, Granata V, Correra M, Tarotto L, Stilo S, Fiore F, Martucci N, Rocca A, Picone C, Muto P, Borzillo V, Belli A, [...] Caraglia M
Cancers (Basel), 15(6):1827, 17 Mar 2023
Cited by: 8 articles | PMID: 36980713 | PMCID: PMC10047282
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Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a CXCR4Leu317fsX3 mutation causing WHIM syndrome.
Kumar R, Milanesi S, Szpakowska M, Dotta L, Di Silvestre D, Trotta AM, Bello AM, Giacomelli M, Benedito M, Azevedo J, Pereira A, Cortesao E, Vacchini A, Castagna A, Pinelli M, Moratto D, Bonecchi R, Locati M, Scala S, [...] Badolato R
JCI Insight, 8(5):e145688, 08 Mar 2023
Cited by: 5 articles | PMID: 36883568 | PMCID: PMC10077478
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Hepatocellular carcinoma (HCC) Tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) Tumor microenvironment.
Santagata S, Castaldo D, Rea G, Napolitano M, Capiluongo A, D'Alterio C, Trotta AM, Ieranò C, Portella L, Tatangelo F, Albino V, Guarino R, Cutolo C, Izzo F, Scala S
Research Square, 10 Jan 2023
Cited by: 0 articles | PPR: PPR594548
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Characterization of KRAS Mutational Regression in Oligometastatic Patients.
Ottaiano A, de Vera d'Aragona RP, Trotta AM, Santorsola M, Napolitano M, Scognamiglio G, Tatangelo F, Grieco P, Zappavigna S, Granata V, Perri F, Luce A, Savarese G, Ianniello M, Casillo M, Petrillo N, Belli A, Izzo F, Nasti G, [...] Scala S
Front Immunol, 13:898561, 22 Jul 2022
Cited by: 8 articles | PMID: 35936004 | PMCID: PMC9354788
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In PD-1+ human colon cancer cells NIVOLUMAB promotes survival and could protect tumor cells from conventional therapies.
Ieranò C, Righelli D, D'Alterio C, Napolitano M, Portella L, Rea G, Auletta F, Santagata S, Trotta AM, Guardascione G, Liotti F, Prevete N, Maiolino P, Luciano A, Barbieri A, Di Mauro A, Roma C, Esposito Abate R, Tatangelo F, [...] Scala S
J Immunother Cancer, 10(3):e004032, 01 Mar 2022
Cited by: 21 articles | PMID: 35246475 | PMCID: PMC8900051
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CXCR4 and CXCR7 Signaling Pathways: A Focus on the Cross-Talk Between Cancer Cells and Tumor Microenvironment.
Santagata S, Ieranò C, Trotta AM, Capiluongo A, Auletta F, Guardascione G, Scala S
Front Oncol, 11:591386, 15 Apr 2021
Cited by: 37 articles | PMID: 33937018 | PMCID: PMC8082172
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Aflibercept or bevacizumab in combination with FOLFIRI as second-line treatment of mRAS metastatic colorectal cancer patients: the ARBITRATION study protocol.
Ottaiano A, Scala S, Santorsola M, Trotta AM, D'Alterio C, Portella L, Clemente O, Nappi A, Zanaletti N, De Stefano A, Avallone A, Granata V, Notariello C, Luce A, Lombardi A, Picone C, Petrillo A, Perri F, Tatangelo F, [...] Nasti G
Ther Adv Med Oncol, 13:1758835921989223, 24 Mar 2021
Cited by: 4 articles | PMID: 33854566 | PMCID: PMC8010802
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Novel Peptide-Based PET Probe for Non-invasive Imaging of C-X-C Chemokine Receptor Type 4 (CXCR4) in Tumors.
Trotta AM, Aurilio M, D'Alterio C, Ieranò C, Di Martino D, Barbieri A, Luciano A, Gaballo P, Santagata S, Portella L, Tomassi S, Marinelli L, Sementa D, Novellino E, Lastoria S, Scala S, Schottelius M, Di Maro S
J Med Chem, 64(6):3449-3461, 04 Mar 2021
Cited by: 8 articles | PMID: 33660512
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Disulfide Bond Replacement with 1,4- and 1,5-Disubstituted [1,2,3]-Triazole on C-X-C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences.
Tomassi S, Trotta AM, Ieranò C, Merlino F, Messere A, Rea G, Santoro F, Brancaccio D, Carotenuto A, D'Amore VM, Di Leva FS, Novellino E, Cosconati S, Marinelli L, Scala S, Di Maro S
Chemistry, 26(44):10113-10125, 20 Jul 2020
Cited by: 4 articles | PMID: 32603023
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New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer.
D'Alterio C, Zannetti A, Trotta AM, Ieranò C, Napolitano M, Rea G, Greco A, Maiolino P, Albanese S, Scognamiglio G, Tatangelo F, Tafuto S, Portella L, Santagata S, Nasti G, Ottaiano A, Pacelli R, Delrio P, Botti G, Scala S
Cancers (Basel), 12(7):E1952, 18 Jul 2020
Cited by: 14 articles | PMID: 32708431 | PMCID: PMC7409147
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Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer.
Ottaiano A, Circelli L, Lombardi A, Scala S, Martucci N, Galon J, Buonanno M, Scognamiglio G, Botti G, Hermitte F, Savarese G, D'Amore L, Tatangelo F, Di Mauro A, Liguori G, Trotta AM, Napolitano M, Capozzi M, Tafuto S, [...] Nasti G
Cell Death Dis, 11(4):275, 24 Apr 2020
Cited by: 20 articles | PMID: 32332709 | PMCID: PMC7181838
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CXCL12 loaded-dermal filler captures CXCR4 expressing melanoma circulating tumor cells.
Ieranò C, D'Alterio C, Giarra S, Napolitano M, Rea G, Portella L, Santagata A, Trotta AM, Barbieri A, Campani V, Luciano A, Arra C, Anniciello AM, Botti G, Mayol L, De Rosa G, Pacelli R, Scala S
Cell Death Dis, 10(8):562, 22 Jul 2019
Cited by: 8 articles | PMID: 31332163 | PMCID: PMC6646345
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Cetuximab, irinotecan and fluorouracile in fiRst-line treatment of immunologically-selected advanced colorectal cancer patients: the CIFRA study protocol.
Ottaiano A, Scala S, Normanno N, Napolitano M, Capozzi M, Rachiglio AM, Roma C, Trotta AM, D'Alterio C, Portella L, Romano C, Cassata A, Casaretti R, Silvestro L, Nappi A, Tafuto S, Avallone A, De Stefano A, Tamburini M, [...] Nasti G
BMC Cancer, 19(1):899, 09 Sep 2019
Cited by: 7 articles | PMID: 31500586 | PMCID: PMC6734266
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Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity.
Trotta AM, Santagata S, Zanotta S, D'Alterio C, Napolitano M, Rea G, Camerlingo R, Esposito F, Lamantia E, Anniciello A, Botti G, Longo N, Botti G, Pignata S, Perdonà S, Scala S
J Exp Clin Cancer Res, 37(1):297, 04 Dec 2018
Cited by: 11 articles | PMID: 30514329 | PMCID: PMC6278085
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Predictive immune biomarkers: an unattainable chimera?
Trotta AM, Pacelli R, Scala S
Cell Mol Immunol, 15(8):740-742, 05 Feb 2018
Cited by: 4 articles | PMID: 29400708 | PMCID: PMC6141568
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Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells.
Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
J Med Chem, 61(7):2910-2923, 19 Mar 2018
Cited by: 8 articles | PMID: 29522685
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Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist.
Di Maro S, Di Leva FS, Trotta AM, Brancaccio D, Portella L, Aurilio M, Tomassi S, Messere A, Sementa D, Lastoria S, Carotenuto A, Novellino E, Scala S, Marinelli L
J Med Chem, 60(23):9641-9652, 20 Nov 2017
Cited by: 13 articles | PMID: 29125295
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Rationale for combination of therapeutic antibodies targeting tumor cells and immune checkpoint receptors: Harnessing innate and adaptive immunity through IgG1 isotype immune effector stimulation.
Ferris RL, Lenz HJ, Trotta AM, García-Foncillas J, Schulten J, Audhuy F, Merlano M, Milano G
Cancer Treat Rev, 63:48-60, 02 Dec 2017
Cited by: 88 articles | PMID: 29223828 | PMCID: PMC7505164
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Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis.
Aversa I, Zolea F, Ieranò C, Bulotta S, Trotta AM, Faniello MC, De Marco C, Malanga D, Biamonte F, Viglietto G, Cuda G, Scala S, Costanzo F
J Exp Clin Cancer Res, 36(1):104, 03 Aug 2017
Cited by: 34 articles | PMID: 28774348 | PMCID: PMC5543736
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