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Search life-sciences literature (45,103,589 articles, preprints and more)

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AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
Schade AE, Perurena N, Yang Y, Rodriguez CL, Krishnan A, Gardner A, Loi P, Xu Y, Nguyen VTM, Mastellone GM, Pilla NF, Watanabe M, Ota K, Davis RA, Mattioli K, Xiang D, Zoeller JJ, Lin JR, Morganti S, [...] Cichowski K
Nature, 09 Oct 2024
Cited by: 0 articles | PMID: 39385030
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Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill KRAS-mutant colorectal cancers.
Loi P, Schade AE, Rodriguez CL, Krishnan A, Perurena N, Nguyen VTM, Xu Y, Watanabe M, Davis RA, Gardner A, Pilla NF, Mattioli K, Popow O, Gunduz N, Lannagan TRM, Fitzgerald S, Sicinska ET, Lin JR, Tan W, [...] Cichowski K
Cancer Discov, 12 Aug 2024
Cited by: 0 articles | PMID: 39121480
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Finding the sweet spot: Targeting RAS in tumors while sparing normal tissue.
Perurena N, Cichowski K
Cancer Cell, 42(6):943-945, 01 Jun 2024
Cited by: 0 articles | PMID: 38861932
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Combinatorial strategies to target RAS-driven cancers.
Perurena N, Situ L, Cichowski K
Nat Rev Cancer, 24(5):316-337, 16 Apr 2024
Cited by: 6 articles | PMID: 38627557
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Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer.
Nardi F, Perurena N, Schade AE, Li ZH, Ngo K, Ivanova EV, Saldanha A, Li C, Gokhale PC, Hata AN, Barbie DA, Paweletz CP, Jänne PA, Cichowski K
J Clin Invest, 133(16):e167651, 15 Aug 2023
Cited by: 5 articles | PMID: 37384411 | PMCID: PMC10425214
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DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer.
Miller AL, Perurena N, Gardner A, Hinoue T, Loi P, Laird PW, Cichowski K
Cancer Res, 83(11):1800-1814, 01 Jun 2023
Cited by: 3 articles | PMID: 36939385 | PMCID: PMC10236151
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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities.
Perurena N, Lock R, Davis RA, Raghavan S, Pilla NF, Ng R, Loi P, Guild CJ, Miller AL, Sicinska E, Cleary JM, Rubinson DA, Wolpin BM, Gray NS, Santagata S, Hahn WC, Morton JP, Sansom OJ, Aguirre AJ, Cichowski K
Cell Rep Med, 4(4):101007, 07 Apr 2023
Cited by: 2 articles | PMID: 37030295 | PMCID: PMC10140597
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Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer.
Ruiz-Fernández de Córdoba B, Moreno H, Valencia K, Perurena N, Ruedas P, Walle T, Pezonaga-Torres A, Hinojosa J, Guruceaga E, Pineda-Lucena A, Abengózar-Muela M, Cochonneau D, Zandueta C, Martínez-Canarias S, Teijeira Á, Ajona D, Ortiz-Espinosa S, Morales X, Ortiz de Solórzano C, [...] Martínez-Monge R
Cancer Discov, 12(5):1356-1377, 01 May 2022
Cited by: 22 articles | PMID: 35191482 | PMCID: PMC7612709
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Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16-mediated Effects.
Ajona D, Zandueta C, Corrales L, Moreno H, Pajares MJ, Ortiz-Espinosa S, Martínez-Terroba E, Perurena N, de Miguel FJ, Jantus-Lewintre E, Camps C, Vicent S, Agorreta J, Montuenga LM, Pio R, Lecanda F
Am J Respir Crit Care Med, 197(9):1164-1176, 01 May 2018
Cited by: 40 articles | PMID: 29327939 | PMCID: PMC6835094
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EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth.
Perurena N, Zandueta C, Martínez-Canarias S, Moreno H, Vicent S, Almeida AS, Guruceaga E, Gomis RR, Santisteban M, Egeblad M, Hermida J, Lecanda F
J Hematol Oncol, 10(1):23, 19 Jan 2017
Cited by: 17 articles | PMID: 28103946 | PMCID: PMC5248526
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An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.
Vallejo A, Perurena N, Guruceaga E, Mazur PK, Martinez-Canarias S, Zandueta C, Valencia K, Arricibita A, Gwinn D, Sayles LC, Chuang CH, Guembe L, Bailey P, Chang DK, Biankin A, Ponz-Sarvise M, Andersen JB, Khatri P, Bozec A, [...] Vicent S
Nat Commun, 8:14294, 21 Feb 2017
Cited by: 88 articles | PMID: 28220783 | PMCID: PMC5321758
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Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps.
Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, Nakasone ES, Hearn SA, Küttner V, Qiu J, Almeida AS, Perurena N, Kessenbrock K, Goldberg MS, Egeblad M
Sci Transl Med, 8(361):361ra138, 01 Oct 2016
Cited by: 475 articles | PMID: 27798263 | PMCID: PMC5550900
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Matrix-Gla protein promotes osteosarcoma lung metastasis and associates with poor prognosis.
Zandueta C, Ormazábal C, Perurena N, Martínez-Canarias S, Zalacaín M, Julián MS, Grigoriadis AE, Valencia K, Campos-Laborie FJ, Rivas Jde L, Vicent S, Patiño-García A, Lecanda F
J Pathol, 239(4):438-449, 29 Jun 2016
Cited by: 29 articles | PMID: 27172275
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Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1.
Weekes D, Kashima TG, Zandueta C, Perurena N, Thomas DP, Sunters A, Vuillier C, Bozec A, El-Emir E, Miletich I, Patiño-Garcia A, Lecanda F, Grigoriadis AE
Oncogene, 35(22):2948, 01 Jun 2016
Cited by: 11 articles | PMID: 27251742
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Bone metastases in lung cancer. Potential novel approaches to therapy.
Vicent S, Perurena N, Govindan R, Lecanda F
Am J Respir Crit Care Med, 192(7):799-809, 01 Oct 2015
Cited by: 19 articles | PMID: 26131844
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Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1.
Weekes D, Kashima TG, Zandueta C, Perurena N, Thomas DP, Sunters A, Vuillier C, Bozec A, El-Emir E, Miletich I, Patiño-Garcia A, Lecanda F, Grigoriadis AE
Oncogene, 35(22):2852-2861, 21 Sep 2015
Cited by: 39 articles | PMID: 26387545 | PMCID: PMC4688957
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A gene signature of bone metastatic colonization sensitizes for tumor-induced osteolysis and predicts survival in lung cancer.
Luis-Ravelo D, Antón I, Zandueta C, Valencia K, Ormazábal C, Martínez-Canarias S, Guruceaga E, Perurena N, Vicent S, De Las Rivas J, Lecanda F
Oncogene, 33(43):5090-5099, 28 Oct 2013
Cited by: 28 articles | PMID: 24166494
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Receptor of activated protein C promotes metastasis and correlates with clinical outcome in lung adenocarcinoma.
Antón I, Molina E, Luis-Ravelo D, Zandueta C, Valencia K, Ormazabal C, Martínez-Canarias S, Perurena N, Pajares MJ, Agorreta J, Montuenga LM, Segura V, Wistuba II, De Las Rivas J, Hermida J, Lecanda F
Am J Respir Crit Care Med, 186(1):96-105, 29 Mar 2012
Cited by: 37 articles | PMID: 22461368 | PMCID: PMC5448647
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