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Search life-sciences literature (45,103,589 articles, preprints and more)

Suggested authors matching "AUTH:Overkleeft H" with an ORCID

Herman Overkleeft
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Structure-guided design of C3-branched swainsonine as potent and selective human Golgi α-mannosidase (GMII) inhibitor.
Koemans T, Bennett M, Ferraz MJ, Armstrong Z, Artola M, Aerts JMFG, Codée JDC, Overkleeft HS, Davies GJ
Chem Commun (Camb), 60(82):11734-11737, 10 Oct 2024
Cited by: 0 articles | PMID: 39318342
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6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols.
Bannink S, Bila KO, van Weperen J, Ligthart NAM, Ferraz MJ, Boot RG, van der Vliet D, Boer DEC, Overkleeft HS, Artola M, Aerts JMFG
J Lipid Res, 65(11):100670, 10 Oct 2024
Cited by: 0 articles | PMID: 39395789
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Synthesis and Biological Evaluation of Deoxycyclophellitols as Human Retaining β-Glucosidase Inhibitors.
Radchenko Y, Su Q, Schröder SS, van Gijlswijk L, Artola M, Aerts JMFG, Codée JDC, Overkleeft HS
Chemistry, e202402988, 21 Sep 2024
Cited by: 0 articles | PMID: 39305182
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From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling.
Artola M, Aerts JMFG, van der Marel GA, Rovira C, Codée JDC, Davies GJ, Overkleeft HS
J Am Chem Soc, 146(36):24729-24741, 30 Aug 2024
Cited by: 0 articles | PMID: 39213505 | PMCID: PMC11403624
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.
Paone P, Latousakis D, Terrasi R, Vertommen D, Jian C, Borlandelli V, Suriano F, Johansson MEV, Puel A, Bouzin C, Delzenne NM, Salonen A, Juge N, Florea BI, Muccioli GG, Overkleeft H, Van Hul M, Cani PD
Gut, 73(10):1632-1649, 09 Sep 2024
Cited by: 2 articles | PMID: 38740509 | PMCID: PMC11420753
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Selective labelling of GBA2 in cells with fluorescent β-d-arabinofuranosyl cyclitol aziridines.
Su Q, Louwerse M, Lammers RF, Maurits E, Janssen M, Boot RG, Borlandelli V, Offen WA, Linzel D, Schröder SP, Davies GJ, Overkleeft HS, Artola M, Aerts JMFG
Chem Sci, 03 Sep 2024
Cited by: 0 articles | PMID: 39246358 | PMCID: PMC11375437
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A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases.
Hou WC, Massey LA, Rhoades D, Wu Y, Ren W, Frank C, Overkleeft HS, Kelly JW
Proc Natl Acad Sci U S A, 121(34):e2320257121, 16 Aug 2024
Cited by: 1 article | PMID: 39150784
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Novel N,N-Dimethyl-idarubicin Analogues Are Effective Cytotoxic Agents for ABCB1-Overexpressing, Doxorubicin-Resistant Cells.
van Gelder MA, Li Y, Wander DPA, Berlin I, Overkleeft HS, van der Zanden SY, Neefjes JJC
J Med Chem, 67(16):13802-13812, 01 Aug 2024
Cited by: 0 articles | PMID: 39088428 | PMCID: PMC11345819
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Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses.
Thaler M, Ofman TP, Kok K, Heming JJA, Moran E, Pickles I, Leijs AA, van den Nieuwendijk AMCH, van den Berg RJBHN, Ruijgrok G, Armstrong Z, Salgado-Benvindo C, Ninaber DK, Snijder EJ, van Boeckel CAA, Artola M, Davies GJ, Overkleeft HS, van Hemert MJ
ACS Cent Sci, 10(8):1594-1608, 25 Jul 2024
Cited by: 1 article | PMID: 39220688 | PMCID: PMC11363342
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Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.
Graboski AL, Simpson JB, Pellock SJ, Mehta N, Creekmore BC, Ariyarathna Y, Bhatt AP, Jariwala PB, Sekela JJ, Kowalewski ME, Barker NK, Mordant AL, Borlandelli VB, Overkleeft H, Herring LE, Jin J, I James L, Redinbo MR
RSC Chem Biol, 5(9):853-865, 16 Jul 2024
Cited by: 0 articles | PMID: 39211470 | PMCID: PMC11353122
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Parascedosporium putredinis NO1 tailors its secretome for different lignocellulosic substrates.
Scott CJR, McGregor NGS, Leadbeater DR, Oates NC, Hoßbach J, Abood A, Setchfield A, Dowle A, Overkleeft HS, Davies GJ, Bruce NC
Microbiol Spectr, 12(7):e0394323, 17 May 2024
Cited by: 0 articles | PMID: 38757984 | PMCID: PMC11218486
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Detection of Sulfoquinovosidase Activity in Cell Lysates Using Activity-Based Probes.
Li Z, Pickles IB, Sharma M, Melling B, Pallasdies L, Codée JDC, Williams SJ, Overkleeft HS, Davies GJ
Angew Chem Int Ed Engl, 63(26):e202401358, 21 May 2024
Cited by: 1 article | PMID: 38647177
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Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Simpson JB, Walker ME, Sekela JJ, Ivey SM, Jariwala PB, Storch CM, Kowalewski ME, Graboski AL, Lietzan AD, Walton WG, Davis KA, Cloer EW, Borlandelli V, Hsiao YC, Roberts LR, Perlman DH, Liang X, Overkleeft HS, Bhatt AP, [...] Redinbo MR
Cell Host Microbe, 32(6):925-944.e10, 15 May 2024
Cited by: 2 articles | PMID: 38754417
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Conformational and Electronic Variations in 1,2- and 1,5a-Cyclophellitols and their Impact on Retaining α-Glucosidase Inhibition.
Ofman TP, Heming JJA, Nin-Hill A, Küllmer F, Moran E, Bennett M, Steneker R, Klein AM, Ruijgrok G, Kok K, Armstrong ZWB, Aerts JMFG, van der Marel GA, Rovira C, Davies GJ, Artola M, Codée JDC, Overkleeft HS
Chemistry, 30(31):e202400723, 24 Apr 2024
Cited by: 1 article | PMID: 38623783
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Synthesis and Macrodomain Binding of Gln-carba-ADPr-peptide.
Engelsma SB, Nardozza AP, de Saint Aulaire P, Overkleeft HS, van der Marel GA, Ladurner AG, Filippov DV
Chembiochem, 25(8):e202300865, 20 Mar 2024
Cited by: 0 articles | PMID: 38442082
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β-l-Arabinofurano-cyclitol Aziridines Are Covalent Broad-Spectrum Inhibitors and Activity-Based Probes for Retaining β-l-Arabinofuranosidases.
Borlandelli V, Offen W, Moroz O, Nin-Hill A, McGregor N, Binkhorst L, Ishiwata A, Armstrong Z, Artola M, Rovira C, Davies GJ, Overkleeft HS
ACS Chem Biol, 18(12):2564-2573, 05 Dec 2023
Cited by: 0 articles | PMID: 38051515 | PMCID: PMC10728902
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Synthesis and application of bacterial exopolysaccharides.
Ruijgrok G, Wu DY, Overkleeft HS, Codée JDC
Curr Opin Chem Biol, 78:102418, 21 Dec 2023
Cited by: 1 article | PMID: 38134611
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Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B.
Chen Y, van den Nieuwendijk AMCH, Wu L, Moran E, Skoulikopoulou F, van Riet V, Overkleeft HS, Davies GJ, Armstrong Z
J Am Chem Soc, 146(1):125-133, 20 Dec 2023
Cited by: 1 article | PMID: 38118176 | PMCID: PMC10785800
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A Multiplexing Activity-Based Protein-Profiling Platform for Dissection of a Native Bacterial Xyloglucan-Degrading System.
McGregor NGS, de Boer C, Foucart QPO, Beenakker T, Offen WA, Codée JDC, Willems LI, Overkleeft HS, Davies GJ
ACS Cent Sci, 9(12):2306-2314, 24 Nov 2023
Cited by: 1 article | PMID: 38161374 | PMCID: PMC10755729
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Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump-hole strategy.
Males A, Kok K, Nin-Hill A, de Koster N, van den Beukel S, Beenakker TJM, van der Marel GA, Codée JDC, Aerts JMFG, Overkleeft HS, Rovira C, Davies GJ, Artola M
Chem Sci, 14(46):13581-13586, 17 Nov 2023
Cited by: 0 articles | PMID: 38033892 | PMCID: PMC10685318
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Solid-Phase Synthesis and Biological Evaluation of Peptides ADP-Ribosylated at Histidine.
Minnee H, Rack JGM, van der Marel GA, Overkleeft HS, Codée JDC, Ahel I, Filippov DV
Angew Chem Weinheim Bergstr Ger, 136(4):e202313317, 14 Nov 2023
Cited by: 0 articles | PMID: 38516349 | PMCID: PMC10952255
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Solid-Phase Synthesis and Biological Evaluation of Peptides ADP-Ribosylated at Histidine.
Minnee H, Rack JGM, van der Marel GA, Overkleeft HS, Codée JDC, Ahel I, Filippov DV
Angew Chem Int Ed Engl, 63(4):e202313317, 14 Nov 2023
Cited by: 2 articles | PMID: 37903139 | PMCID: PMC10952301
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Synthetic Dual Cysteine-ADP Ribosylated Peptides from the Androgen Receptor are Recognized by the DTX3L/PARP9 Complex.
Wijngaarden S, Yang C, Vela-Rodríguez C, Lehtiö L, Overkleeft HS, Paschal BM, Filippov DV
ACS Chem Biol, 18(11):2377-2384, 08 Nov 2023
Cited by: 2 articles | PMID: 37939374 | PMCID: PMC10660311
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The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe.
Kuo CL, Su Q, van den Nieuwendijk AMCH, Beenakker TJM, Offen WA, Willems LI, Boot RG, Sarris AJ, Marques ARA, Codée JDC, van der Marel GA, Florea BI, Davies GJ, Overkleeft HS, Aerts JMFG
Org Biomol Chem, 21(38):7813-7820, 04 Oct 2023
Cited by: 2 articles | PMID: 37724332
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Selection and enrichment of microbial species with an increased lignocellulolytic phenotype from a native soil microbiome by activity-based probing.
Reichart NJ, Steiger AK, Van Fossen EM, McClure R, Overkleeft HS, Wright AT
ISME Commun, 3(1):106, 30 Sep 2023
Cited by: 1 article | PMID: 37777628 | PMCID: PMC10542759
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Structure-guided design of C3-branched swainsonine as potent and selective human Golgi α-mannosidase (GMII) inhibitor.

6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols.

Synthesis and Biological Evaluation of Deoxycyclophellitols as Human Retaining β-Glucosidase Inhibitors.

From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling.

Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.

Selective labelling of GBA2 in cells with fluorescent β-d-arabinofuranosyl cyclitol aziridines.

A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases.

Novel N,N-Dimethyl-idarubicin Analogues Are Effective Cytotoxic Agents for ABCB1-Overexpressing, Doxorubicin-Resistant Cells.

Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses.

Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.

Parascedosporium putredinis NO1 tailors its secretome for different lignocellulosic substrates.

Detection of Sulfoquinovosidase Activity in Cell Lysates Using Activity-Based Probes.

Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.

Conformational and Electronic Variations in 1,2- and 1,5a-Cyclophellitols and their Impact on Retaining α-Glucosidase Inhibition.

Synthesis and Macrodomain Binding of Gln-carba-ADPr-peptide.

β-l-Arabinofurano-cyclitol Aziridines Are Covalent Broad-Spectrum Inhibitors and Activity-Based Probes for Retaining β-l-Arabinofuranosidases.

Synthesis and application of bacterial exopolysaccharides.

Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B.

A Multiplexing Activity-Based Protein-Profiling Platform for Dissection of a Native Bacterial Xyloglucan-Degrading System.

Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump-hole strategy.

Solid-Phase Synthesis and Biological Evaluation of Peptides ADP-Ribosylated at Histidine.

Solid-Phase Synthesis and Biological Evaluation of Peptides ADP-Ribosylated at Histidine.

Synthetic Dual Cysteine-ADP Ribosylated Peptides from the Androgen Receptor are Recognized by the DTX3L/PARP9 Complex.

The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe.

Selection and enrichment of microbial species with an increased lignocellulolytic phenotype from a native soil microbiome by activity-based probing.

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