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Search life-sciences literature (45,103,589 articles, preprints and more)

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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.
Chen CCL, Deshmukh S, Jessa S, Hadjadj D, Lisi V, Andrade AF, Faury D, Jawhar W, Dali R, Suzuki H, Pathania M, A D, Dubois F, Woodward E, Hébert S, Coutelier M, Karamchandani J, Albrecht S, Brandner S, [...] Jabado N
Cell, 183(6):1617-1633.e22, 30 Nov 2020
Cited by: 84 articles | PMID: 33259802 | PMCID: PMC7791404
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H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone.
Khazaei S, De Jay N, Deshmukh S, Hendrikse LD, Jawhar W, Chen CCL, Mikael LG, Faury D, Marchione DM, Lanoix J, Bonneil É, Ishii T, Jain SU, Rossokhata K, Sihota TS, Eveleigh R, Lisi V, Harutyunyan AS, Jung S, [...] Jabado N
Cancer Discov, 10(12):1968-1987, 23 Sep 2020
Cited by: 35 articles | PMID: 32967858 | PMCID: PMC7710565
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Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.
Krug B, De Jay N, Harutyunyan AS, Deshmukh S, Marchione DM, Guilhamon P, Bertrand KC, Mikael LG, McConechy MK, Chen CCL, Khazaei S, Koncar RF, Agnihotri S, Faury D, Ellezam B, Weil AG, Ursini-Siegel J, De Carvalho DD, Dirks PB, [...] Mack SC
Cancer Cell, 36(3):338-339, 01 Sep 2019
Cited by: 15 articles | PMID: 31526762 | PMCID: PMC6949014
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Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness.
Boileau M, Shirinian M, Gayden T, Harutyunyan AS, Chen CCL, Mikael LG, Duncan HM, Neumann AL, Arreba-Tutusaus P, De Jay N, Zeinieh M, Rossokhata K, Zhang Y, Nikbakht H, Mouawad C, Massoud R, Frey F, Nasr R, El Cheikh J, [...] Eppert K
Nat Commun, 10(1):2891, 28 Jun 2019
Cited by: 28 articles | PMID: 31253791 | PMCID: PMC6599207
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Stalled developmental programs at the root of pediatric brain tumors.
Jessa S, Blanchet-Cohen A, Krug B, Vladoiu M, Coutelier M, Faury D, Poreau B, De Jay N, Hébert S, Monlong J, Farmer WT, Donovan LK, Hu Y, McConechy MK, Cavalli FMG, Mikael LG, Ellezam B, Richer M, Allaire A, [...] Kleinman CL
Nat Genet, 51(12):1702-1713, 25 Nov 2019
Cited by: 112 articles | PMID: 31768071 | PMCID: PMC6885128
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Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.
Krug B, De Jay N, Harutyunyan AS, Deshmukh S, Marchione DM, Guilhamon P, Bertrand KC, Mikael LG, McConechy MK, Chen CCL, Khazaei S, Koncar RF, Agnihotri S, Faury D, Ellezam B, Weil AG, Ursini-Siegel J, De Carvalho DD, Dirks PB, [...] Mack SC
Cancer Cell, 35(5):782-797.e8, 01 May 2019
Cited by: 99 articles | PMID: 31085178 | PMCID: PMC6521975
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H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.
Harutyunyan AS, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N, Deshmukh S, Chen CCL, Belle J, Mikael LG, Marchione DM, Li R, Nikbakht H, Hu B, Cagnone G, Cheung WA, Mohammadnia A, Bechet D, Faury D, [...] Majewski J
Nat Commun, 10(1):1262, 19 Mar 2019
Cited by: 170 articles | PMID: 30890717 | PMCID: PMC6425035
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Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.
Gayden T, Sepulveda FE, Khuong-Quang DA, Pratt J, Valera ET, Garrigue A, Kelso S, Sicheri F, Mikael LG, Hamel N, Bajic A, Dali R, Deshmukh S, Dervovic D, Schramek D, Guerin F, Taipale M, Nikbakht H, Majewski J, [...] Jabado N
Nat Genet, 51(1):196, 01 Jan 2019
Cited by: 0 articles | PMID: 30429576
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Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.
Gayden T, Sepulveda FE, Khuong-Quang DA, Pratt J, Valera ET, Garrigue A, Kelso S, Sicheri F, Mikael LG, Hamel N, Bajic A, Dali R, Deshmukh S, Dervovic D, Schramek D, Guerin F, Taipale M, Nikbakht H, Majewski J, [...] Jabado N
Nat Genet, 50(12):1650-1657, 29 Oct 2018
Cited by: 92 articles | PMID: 30374066
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TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw.
Gomes CC, Gayden T, Bajic A, Harraz OF, Pratt J, Nikbakht H, Bareke E, Diniz MG, Castro WH, St-Onge P, Sinnett D, Han H, Rivera B, Mikael LG, De Jay N, Kleinman CL, Valera ET, Bassenden AV, Berghuis AM, [...] Jabado N
Nat Commun, 9(1):4572, 01 Nov 2018
Cited by: 21 articles | PMID: 30385747 | PMCID: PMC6212533
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H3.3^K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.
Pathania M, De Jay N, Maestro N, Harutyunyan AS, Nitarska J, Pahlavan P, Henderson S, Mikael LG, Richard-Londt A, Zhang Y, Costa JR, Hébert S, Khazaei S, Ibrahim NS, Herrero J, Riccio A, Albrecht S, Ketteler R, Brandner S, [...] Salomoni P
Cancer Cell, 32(5):684-700.e9, 26 Oct 2017
Cited by: 139 articles | PMID: 29107533 | PMCID: PMC5687892
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Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas.
Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, [...] Jabado N
Acta Neuropathol Commun, 5(1):78, 30 Oct 2017
Cited by: 37 articles | PMID: 29084603 | PMCID: PMC5663045
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Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.
Papillon-Cavanagh S, Lu C, Gayden T, Mikael LG, Bechet D, Karamboulas C, Ailles L, Karamchandani J, Marchione DM, Garcia BA, Weinreb I, Goldstein D, Lewis PW, Dancu OM, Dhaliwal S, Stecho W, Howlett CJ, Mymryk JS, Barrett JW, [...] Jabado N
Nat Genet, 49(2):180-185, 09 Jan 2017
Cited by: 153 articles | PMID: 28067913 | PMCID: PMC5549104
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Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma.
Nikbakht H, Panditharatna E, Mikael LG, Li R, Gayden T, Osmond M, Ho CY, Kambhampati M, Hwang EI, Faury D, Siu A, Papillon-Cavanagh S, Bechet D, Ligon KL, Ellezam B, Ingram WJ, Stinson C, Moore AS, Warren KE, [...] Nazarian J
Nat Commun, 7:11185, 06 Apr 2016
Cited by: 153 articles | PMID: 27048880 | PMCID: PMC4823825
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High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.
Christensen KE, Mikael LG, Leung KY, Lévesque N, Deng L, Wu Q, Malysheva OV, Best A, Caudill MA, Greene ND, Rozen R
Am J Clin Nutr, 101(3):646-658, 07 Jan 2015
Cited by: 81 articles | PMID: 25733650 | PMCID: PMC4340065
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Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.
Leclerc D, Cao Y, Deng L, Mikael LG, Wu Q, Rozen R
Mol Nutr Food Res, 57(4):686-697, 24 Sep 2012
Cited by: 13 articles | PMID: 23001810
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Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Mikael LG, Pancer J, Jiang X, Wu Q, Caudill M, Rozen R
Mol Nutr Food Res, 57(4):661-670, 30 Oct 2012
Cited by: 16 articles | PMID: 23112124
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Moderately high intake of folic acid has a negative impact on mouse embryonic development.
Mikael LG, Deng L, Paul L, Selhub J, Rozen R
Birth Defects Res A Clin Mol Teratol, 97(1):47-52, 02 Nov 2012
Cited by: 47 articles | PMID: 23125102
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Disturbed one-carbon metabolism causing adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators PPARα, interferon-γ, and interleukin-10.
Mikael LG, Pancer J, Wu Q, Rozen R
J Nutr, 142(3):411-418, 18 Jan 2012
Cited by: 12 articles | PMID: 22259189
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Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency.
Mikael LG, Wang XL, Wu Q, Jiang H, Maclean KN, Rozen R
Mol Genet Metab, 98(1-2):187-194, 23 Jun 2009
Cited by: 20 articles | PMID: 19560954
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Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice.
Chan J, Deng L, Mikael LG, Yan J, Pickell L, Wu Q, Caudill MA, Rozen R
Am J Clin Nutr, 91(4):1035-1043, 17 Feb 2010
Cited by: 29 articles | PMID: 20164309
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Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kappaB/iNOS.
Mikael LG, Rozen R
Cardiovasc Res, 80(1):151-158, 07 Jun 2008
Cited by: 14 articles | PMID: 18540024
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Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice.
Pickell L, Li D, Brown K, Mikael LG, Wang XL, Wu Q, Luo L, Jerome-Majewska L, Rozen R
Birth Defects Res A Clin Mol Teratol, 85(6):531-541, 01 Jun 2009
Cited by: 46 articles | PMID: 19215022
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Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.
Schwahn BC, Wang XL, Mikael LG, Wu Q, Cohn J, Jiang H, Maclean KN, Rozen R
Atherosclerosis, 195(2):e100-7, 09 Aug 2007
Cited by: 23 articles | PMID: 17689540
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Fhua and HgbA, outer membrane proteins of Actinobacillus pleuropneumoniae: their role as virulence determinants.
Shakarji L, Mikael LG, Srikumar R, Kobisch M, Coulton JW, Jacques M
Can J Microbiol, 52(4):391-396, 01 Apr 2006
Cited by: 11 articles | PMID: 16699590
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