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Search life-sciences literature (45,103,589 articles, preprints and more)

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Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.
Ridnour LA, Heinz WF, Cheng RYS, Wink AL, Kedei N, Pore M, Imtiaz F, Femino EL, Gonzalez AL, Coutinho LL, Moffat RL, Butcher D, Edmondson EF, Li X, Rangel MC, Kinders RJ, Rittscher J, Lipkowitz S, Wong STC, [...] Wink DA
Cancer Res Commun, 4(10):2766-2782, 01 Oct 2024
Cited by: 0 articles | PMID: 39356141 | PMCID: PMC11497117
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TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers
Kundu M, Greer YE, Lobanov A, Ridnour L, Donahue RN, Ng Y, Ratnayake S, Voeller D, Weltz S, Chen Q, Lockett SJ, Cam M, Meerzaman D, Wink DA, Weigert R, Lipkowitz S
bioRxiv, 23 Jul 2024
Cited by: 0 articles | PPR: PPR885363
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NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer.
Coutinho LL, Femino EL, Gonzalez AL, Moffat RL, Heinz WF, Cheng RYS, Lockett SJ, Rangel MC, Ridnour LA, Wink DA
Int J Mol Sci, 25(11):6103, 01 Jun 2024
Cited by: 0 articles | PMID: 38892290 | PMCID: PMC11173351
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Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors.
Ridnour LA, Cheng RY, Kedei N, Somasundaram V, Bhattacharyya DD, Basudhar D, Wink AL, Walke AJ, Kim C, Heinz WF, Edmondson EF, Butcher DO, Warner AC, Dorsey TH, Pore M, Kinders RJ, Lipkowitz S, Bryant RJ, Rittscher J, [...] Wink DA
JCI Insight, 9(12):e165356, 21 May 2024
Cited by: 0 articles | PMID: 38912586 | PMCID: PMC11383366
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Odevixibat: A Novel Bile Salt Inhibitor Treatment for Pruritus in Progressive Familial Intrahepatic Cholestasis.
Flattmann FE, Mohiuddin FS, Singh A, Tandon A, Lockett SJ, Hirsch JD, Mosieri CN, Kaye AM, Varrassi G, Ahmadzadeh S, Shekoohi S, Kaye AD
Cureus, 16(3):e56886, 25 Mar 2024
Cited by: 0 articles | PMID: 38659510 | PMCID: PMC11042757
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NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER-Breast Cancer
Ridnour LA, Heinz WF, Cheng RY, Wink AL, Kedei N, Pore M, Imtiaz F, Femino EL, Gonzalez AL, Coutinho L, Butcher D, Edmondson EF, Rangel MC, Kinders RJ, Lipkowitz S, Wong ST, Anderson SK, McVicar DW, Li X, [...] Wink DA
bioRxiv, 23 Dec 2023
Cited by: 0 articles | PPR: PPR778124
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Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patients
Ridnour LA, Cheng RY, Heinz WF, Pore M, Gonzalez AL, Femino EL, Moffat R, Wink AL, Imtiaz F, Coutinho L, Butcher D, Edmondson EF, Rangel MC, Wong ST, Lipkowitz S, Glynn S, Vitek MP, McVicar DW, Li X, [...] Wink DA
bioRxiv, 23 Dec 2023
Cited by: 0 articles | PPR: PPR778163
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Vigabatrin (Sabril) for the Treatment of Refractory Complex Focal Seizures in Adults: Pharmacologic and Clinical Considerations.
Gatson TN, Freemont OA, Coleman RL, Lockett SJ, Spillers NJ, Ahmadzadeh S, Viswanath O, Varrassi G, Shekoohi S, Kaye AD
Cureus, 15(10):e46414, 03 Oct 2023
Cited by: 1 article | PMID: 37927747 | PMCID: PMC10621625
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Interferon-gamma is quintessential for NOS2 and COX2 expression in ER^- breast tumors that lead to poor outcome.
Cheng RYS, Ridnour LA, Wink AL, Gonzalez AL, Femino EL, Rittscher H, Somasundaram V, Heinz WF, Coutinho L, Rangel MC, Edmondson EF, Butcher D, Kinders RJ, Li X, Wong STC, McVicar DW, Anderson SK, Pore M, Hewitt SM, [...] Wink DA
Cell Death Dis, 14(5):319, 11 May 2023
Cited by: 7 articles | PMID: 37169743 | PMCID: PMC10175544
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Interferon-gamma is Quintessential for NOS2 and COX2 Expression in ER^-Breast Tumors that Lead to Poor Outcome
Cheng RY, Ridnour LA, Wink AL, Gonzalez AL, Femino EL, Rittscher H, Somasundarum V, Heinz WF, Coutinho L, Cristina Rangel M, Edmondson EF, Butcher D, Kinders RJ, Li X, Wong ST, McVicar DW, Anderson SK, Pore M, Hewitt SM, [...] Wink DA
bioRxiv, 06 Apr 2023
Cited by: 0 articles | PPR: PPR642309
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Visualizing and Quantifying mRNA Localization at the Invasive Front of 3D Cancer Spheroids.
Moissoglu K, Lockett SJ, Mili S
Methods Mol Biol, 2608:263-280, 01 Jan 2023
Cited by: 0 articles | PMID: 36653713 | PMCID: PMC10411857
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Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density.
Somasundaram V, Ridnour LA, Cheng RY, Walke AJ, Kedei N, Bhattacharyya DD, Wink AL, Edmondson EF, Butcher D, Warner AC, Dorsey TH, Scheiblin DA, Heinz W, Bryant RJ, Kinders RJ, Lipkowitz S, Wong ST, Pore M, Hewitt SM, [...] Wink DA
Redox Biol, 58:102529, 09 Nov 2022
Cited by: 11 articles | PMID: 36375380 | PMCID: PMC9661390
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NOS2 and COX2 Blockade Limits TNBC Disease Progression and Alters CD8⁺T Cell Spatial Orientation and Density
Somasundaram V, Ridnour LA, Cheng RY, Walke AJ, Kedei N, Bhattacharyya DD, Wink AL, Edmondson EF, Butcher D, Warner A, Dorsey TH, Scheiblin DA, Heinz W, Bryant RJ, Kinders R, Lipkowitz S, Wong ST, Pore M, Hewitt SM, [...] Wink DA
bioRxiv, 04 Jun 2022
Cited by: 0 articles | PPR: PPR502537
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Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer.
Sjoberg HT, Philippou Y, Magnussen AL, Tullis IDC, Bridges E, Chatrian A, Lefebvre J, Tam KH, Murphy EA, Rittscher J, Preise D, Agemy L, Yechezkel T, Smart SC, Kinchesh P, Gilchrist S, Allen DP, Scheiblin DA, Lockett SJ, [...] Bryant RJ
Br J Cancer, 125(4):534-546, 21 Jun 2021
Cited by: 4 articles | PMID: 34155340 | PMCID: PMC8367986
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Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment.
McGinity CL, Palmieri EM, Somasundaram V, Bhattacharyya DD, Ridnour LA, Cheng RYS, Ryan AE, Glynn SA, Thomas DD, Miranda KM, Anderson SK, Lockett SJ, McVicar DW, Wink DA
Int J Mol Sci, 22(13):7068, 30 Jun 2021
Cited by: 11 articles | PMID: 34209132 | PMCID: PMC8268115
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An in vitro tumorigenesis model based on live-cell-generated oxygen and nutrient gradients.
Gilmore AC, Flaherty SJ, Somasundaram V, Scheiblin DA, Lockett SJ, Wink DA, Heinz WF
Commun Biol, 4(1):477, 15 Apr 2021
Cited by: 7 articles | PMID: 33859337 | PMCID: PMC8050328
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Tumor irradiation combined with vascular-targeted photodynamic therapy enhances anti-tumor effects in preclinical prostate cancer
Sjoberg HT, Philippou Y, Magnussen AL, Tullis ID, Bridges E, Chatrian A, Loefebvre J, Tam KH, Murphy EA, Rittscher J, Preise D, Agemy L, Yechezkel T, Smart SC, Kinchesh P, Gilchrist S, Allen DP, Scheiblin DA, Lockett SJ, [...] Bryant RJ
bioRxiv, 26 Nov 2020
Cited by: 0 articles | PPR: PPR245579
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Anin vitrotumorigenesis model based on live cell-generated oxygen and nutrient gradients
Gilmore AC, Flaherty SJ, Somasundaram V, Scheiblin DA, Lockett SJ, Wink DA, Heinz WF
bioRxiv, 25 Aug 2020
Cited by: 0 articles | PPR: PPR205405
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Collective cancer cell invasion requires RNA accumulation at the invasive front.
Chrisafis G, Wang T, Moissoglu K, Gasparski AN, Ng Y, Weigert R, Lockett SJ, Mili S
Proc Natl Acad Sci U S A, 117(44):27423-27434, 15 Oct 2020
Cited by: 24 articles | PMID: 33060293 | PMCID: PMC7959543
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Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model.
Philippou Y, Sjoberg HT, Murphy E, Alyacoubi S, Jones KI, Gordon-Weeks AN, Phyu S, Parkes EE, Gillies McKenna W, Lamb AD, Gileadi U, Cerundolo V, Scheiblin DA, Lockett SJ, Wink DA, Mills IG, Hamdy FC, Muschel RJ, Bryant RJ
Br J Cancer, 123(7):1089-1100, 09 Jul 2020
Cited by: 39 articles | PMID: 32641865 | PMCID: PMC7525450
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Inducible nitric oxide synthase-derived extracellular nitric oxide flux regulates proinflammatory responses at the single cell level.
Somasundaram V, Gilmore AC, Basudhar D, Palmieri EM, Scheiblin DA, Heinz WF, Cheng RYS, Ridnour LA, Altan-Bonnet G, Lockett SJ, McVicar DW, Wink DA
Redox Biol, 28:101354, 01 Nov 2019
Cited by: 25 articles | PMID: 31683257 | PMCID: PMC6920088
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The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation.
Matarlo JS, Krumpe LRH, Heinz WF, Oh D, Shenoy SR, Thomas CL, Goncharova EI, Lockett SJ, O'Keefe BR
Cell Chem Biol, 26(8):1133-1142.e4, 30 May 2019
Cited by: 22 articles | PMID: 31155509 | PMCID: PMC6697619
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Photoinducible Oncometabolite Detection.
Kulkarni RA, Briney CA, Crooks DR, Bergholtz SE, Mushti C, Lockett SJ, Lane AN, Fan TW, Swenson RE, Marston Linehan W, Meier JL
Chembiochem, 20(3):360-365, 13 Dec 2018
Cited by: 9 articles | PMID: 30358041 | PMCID: PMC8141106
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Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective.
Basudhar D, Bharadwaj G, Somasundaram V, Cheng RYS, Ridnour LA, Fujita M, Lockett SJ, Anderson SK, McVicar DW, Wink DA
Br J Pharmacol, 176(2):155-176, 06 Nov 2018
Cited by: 25 articles | PMID: 30152521 | PMCID: PMC6295414
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Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer.
Basudhar D, Glynn SA, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RYS, Ridnour LA, Lockett SJ, McVicar DW, Ambs S, Wink DA
Proc Natl Acad Sci U S A, 114(49):13030-13035, 27 Oct 2017
Cited by: 57 articles | PMID: 29087320 | PMCID: PMC5724261
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